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Cited by 320

The DOI matches its Crossref record; 12 of the 12 references it cites were found in a registry or an index.

Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo

Open access
Woll, Petter S., Kjällquist, Una, Chowdhury, Onima, Doolittle, Helen, Wedge, David C., Thongjuea, Supat, Erlandsson, Rikard, Ngara, Mtakai, Anderson, Kristina, Deng, Qiaolin, Mead, Adam J., Stenson, Laura, Giustacchini, Alice, Duarte, Sara, Giannoulatou, Eleni, Taylor, Stephen, Karimi, Mohsen, Scharenberg, Christian, Mortera-Blanco, Teresa, Macaulay, Iain C., Clark, Sally-Ann, Dybedal, Ingunn, Josefsen, Dag, Fenaux, Pierre, Hokland, Peter, Holm, Mette S., Cazzola, Mario, Malcovati, Luca, Tauro, Sudhir, Bowen, David, Boultwood, Jacqueline, Pellagatti, Andrea, Pimanda, John E., Unnikrishnan, Ashwin, Vyas, Paresh, Göhring, Gudrun, Schlegelberger, Brigitte, Tobiasson, Magnus, Kvalheim, Gunnar, Constantinescu, Stefan N., Nerlov, Claus, Nilsson, Lars, Campbell, Peter J., Sandberg, Rickard, Papaemmanuil, Elli, Hellström-Lindberg, Eva, Linnarsson, Sten, Jacobsen, Sten Eirik W.·2014·Cancer Cell
DOI 10.1016/j.ccr.2014.03.036
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Abstract

Evidence for distinct human cancer stem cells (CSCs) remains contentious and the degree to which different cancer cells contribute to propagating malignancies in patients remains unexplored. In low- to intermediate-risk myelodysplastic syndromes (MDS), we establish the existence of rare multipotent MDS stem cells (MDS-SCs), and their hierarchical relationship to lineage-restricted MDS progenitors. All identified somatically acquired genetic lesions were backtracked to distinct MDS-SCs, establishing their distinct MDS-propagating function in vivo. In isolated del(5q)-MDS, acquisition of del(5q) preceded diverse recurrent driver mutations. Sequential analysis in del(5q)-MDS revealed genetic evolution in MDS-SCs and MDS-progenitors prior to leukemic transformation. These findings provide definitive evidence for rare human MDS-SCs in vivo, with extensive implications for the targeting of the cells required and sufficient for MDS-propagation.

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Metadata

Authors
Woll, P. S., Kjällquist, U., Chowdhury, O., Doolittle, H., Wedge, D. C., Thongjuea, S., Erlandsson, R., Ngara, M., Anderson, K., Deng, Q., Mead, A. J., Stenson, L., Giustacchini, A., Duarte, S., Giannoulatou, E., Taylor, S., Karimi, M., Scharenberg, C., Mortera-Blanco, T., Macaulay, I. C., Clark, S.-A., Dybedal, I., Josefsen, D., Fenaux, P., Hokland, P., Holm, M. S., Cazzola, M., Malcovati, L., Tauro, S., Bowen, D., Boultwood, J., Pellagatti, A., Pimanda, J. E., Unnikrishnan, A., Vyas, P., Göhring, G., Schlegelberger, B., Tobiasson, M., Kvalheim, G., Constantinescu, S. N., Nerlov, C., Nilsson, L., Campbell, P. J., Sandberg, R., Papaemmanuil, E., Hellström-Lindberg, E., Linnarsson, S., & Jacobsen, S. E. W.
Venue
Cancer Cell
Publisher
Elsevier BV
Published
2014-06
Volume
25
Issue
6
Pages
794-808
ISSN
1535-6108 (ISSN-L)
DOI
10.1016/j.ccr.2014.03.036
OpenAlex
W2027950772
Cited by
320
References
12
FWCI
22.86
Type
journal article
Language
en
Open access
bronze

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The paper
Woll, P. S., Kjällquist, U., Chowdhury, O., Doolittle, H., Wedge, D. C., Thongjuea, S., Erlandsson, R., Ngara, M., Anderson, K., Deng, Q., Mead, A. J., Stenson, L., Giustacchini, A., Duarte, S., Giannoulatou, E., Taylor, S., Karimi, M., Scharenberg, C., Mortera-Blanco, T., . . . Jacobsen, S. E. W. (2014). Myelodysplastic Syndromes Are Propagated by Rare and Distinct Human Cancer Stem Cells In Vivo. Cancer Cell. https://doi.org/10.1016/j.ccr.2014.03.036

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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.