Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

Jan, Max; Snyder, Thomas M.; Corces-Zimmerman, M. Ryan; Vyas, Paresh; Weissman, Irving L.; Quake, Stephen R.; Majeti, Ravindra

doi:10.1126/scitranslmed.3004315

Clonal Evolution of Preleukemic Hematopoietic Stem Cells Precedes Human Acute Myeloid Leukemia

Exome sequencing and single-cell analysis reveals that a clonal progression of mutations in hematopoietic stem cells precedes human acute myeloid leukemia.