Leukemia Propagating Cells Rebuild an Evolving Niche in Response to Therapy

Hallmarks of Cancer: The Next Generation

Hanahan, D., & Weinberg, R. A. (2011) · Cell · doi:10.1016/j.cell.2011.02.013 · Cited by 66,590

Osteoblastic cells regulate the haematopoietic stem cell niche

Calvi, L. M., Adams, G. B., Weibrecht, K. W., Weber, J. M., Olson, D. P., Knight, M. C., Martin, R. P., Schipani, E., Pajevic, P. D., Bringhurst, F. R., et al. (2003) · Nature · doi:10.1038/nature02040 · Cited by 3,559

Mesenchymal and haematopoietic stem cells form a unique bone marrow niche

Méndez‐Ferrer, S., Michurina, T. V., Ferraro, F., Mazloom, A. R., MacArthur, B. D., Lira, S. A., Scadden, D. T., Ma’ayan, A., Enikolopov, G., & Frenette, P. S. (2010) · Nature · doi:10.1038/nature09262 · Cited by 3,381

SLAM Family Receptors Distinguish Hematopoietic Stem and Progenitor Cells and Reveal Endothelial Niches for Stem Cells

Kiel, M. J., Yilmaz, Ö. H., Iwashita, T., Yilmaz, O. H., Terhorst, C., & Morrison, S. J. (2005) · Cell · doi:10.1016/j.cell.2005.05.026 · Cited by 3,168

Identification of the haematopoietic stem cell niche and control of the niche size

Zhang, J., Niu, C. S., Ye, L., Huang, H., He, X. C., Tong, W.-G., Ross, J., Haug, J., Johnson, T. J., Feng, J. Q., et al. (2003) · Nature · doi:10.1038/nature02041 · Cited by 2,948

A Chromatin-Mediated Reversible Drug-Tolerant State in Cancer Cell Subpopulations

Sharma, S. V., Lee, D. Y., Li, B., Quinlan, M. P., Takahashi, F., Maheswaran, S., McDermott, U., Azizian, N., Zou, L., Fischbach, M. A., et al. (2010) · Cell · doi:10.1016/j.cell.2010.02.027 · Cited by 2,770

Clonal evolution in relapsed acute myeloid leukaemia revealed by whole-genome sequencing

Ding, L., Ley, T. J., Larson, D. E., Miller, C. A., Koboldt, D. C., Welch, J. S., Ritchey, J. K., Young, M. A., Lamprecht, T., McLellan, M. D., et al. (2012) · Nature · doi:10.1038/nature10738 · Cited by 1,993

Bone-marrow haematopoietic-stem-cell niches

Wilson, A., & Trumpp, A. (2006) · Nature reviews. Immunology · doi:10.1038/nri1779 · Cited by 1,420

Arteriolar niches maintain haematopoietic stem cell quiescence

Kunisaki, Y., Bruns, I., Scheiermann, C., Ahmed, J. U., Pinho, S., Zhang, D., Mizoguchi, T., Wei, Q., Lucas, D., Ito, K., et al. (2013) · Nature · doi:10.1038/nature12612 · Cited by 1,290

Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region

Ishikawa, F., Yoshida, S., Saito, Y., Hijikata, A., Kitamura, H., Tanaka, S., Nakamura, R., Tanaka, T., Tomiyama, H., Saito, N., et al. (2007) · Nature Biotechnology · doi:10.1038/nbt1350 · Cited by 1,025

Tumor microenvironment: Sanctuary of the devil

Hui, L., & Chen, Y. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.039 · Cited by 797

Microenvironmental regulation of therapeutic response in cancer

Klemm, F., & Joyce, J. A. (2014) · Trends in Cell Biology · doi:10.1016/j.tcb.2014.11.006 · Cited by 795

New horizons in tumor microenvironment biology: challenges and opportunities

Chen, F., Zhuang, X., Lin, L., Yu, P., Wang, Y., Shi, Y., Hu, G., & Sun, Y. (2015) · BMC Medicine · doi:10.1186/s12916-015-0278-7 · Cited by 704

Tumor microenvironment and cancer therapy resistance

Sun, Y. (2015) · Cancer Letters · doi:10.1016/j.canlet.2015.07.044 · Cited by 391

Inhibition of Endosteal Vascular Niche Remodeling Rescues Hematopoietic Stem Cell Loss in AML

Duarte, D., Hawkins, E. D., Akinduro, O., Ang, H. Y.-K., Filippo, K. D., Kong, I. Y., Haltalli, M. L. R., Ruivo, N., Straszkowski, L., Vervoort, S. J., et al. (2017) · Cell stem cell · doi:10.1016/j.stem.2017.11.006 · Cited by 328

Therapy resistance mediated by cancer stem cells

Steinbichler, T. B., Dudás, J., Skvortsov, S., Ganswindt, U., Riechelmann, H., & Skvortsova, I. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.11.006 · Cited by 298

Activated stromal cells transfer mitochondria to rescue acute lymphoblastic leukemia cells from oxidative stress

Burt, R. J., Dey, A., Aref, S., Aguiar, M., Akarca, A. U., Bailey, K., Day, W. P., Hooper, S., Kirkwood, A. A., Kirschner, K., et al. (2019) · Blood · doi:10.1182/blood.2019001398 · Cited by 249

The hematopoietic stem cell niche in homeostasis and disease

Calvi, L. M., & Link, D. C. (2015) · Blood · doi:10.1182/blood-2015-07-533588 · Cited by 238

T-cell acute leukaemia exhibits dynamic interactions with bone marrow microenvironments

Hawkins, E. D., Duarte, D., Akinduro, O., Khorshed, R., Passaro, D., Nowicka, M., Straszkowski, L., Scott, M., Rothery, S., Ruivo, N., et al. (2016) · Nature · doi:10.1038/nature19801 · Cited by 208

Bone metastasis and the metastatic niche

Ren, G., Esposito, M., & Kang, Y. (2015) · Journal of Molecular Medicine · doi:10.1007/s00109-015-1329-4 · Cited by 167

Therapeutic Antibody Targeting Tumor- and Osteoblastic Niche-Derived Jagged1 Sensitizes Bone Metastasis to Chemotherapy

Zheng, H., Bae, Y., Kasimir‐Bauer, S., Tang, R. B., Chen, J., Ren, G., Yuan, M., Esposito, M., Li, W., Wei, Y., et al. (2017) · Cancer Cell · doi:10.1016/j.ccell.2017.11.002 · Cited by 163

Epidemiology and biology of relapse after stem cell transplantation

Horowitz, M. M., Schreiber, H. W., Elder, A., Heidenreich, O. T., Vormoor, J. H., Toffalori, C., Vago, L., & Kröger, N. M. (2018) · Bone Marrow Transplantation · doi:10.1038/s41409-018-0171-z · Cited by 156

N-Cadherin-Expressing Bone and Marrow Stromal Progenitor Cells Maintain Reserve Hematopoietic Stem Cells

Zhao, M., Tao, F., Venkatraman, A., Li, Z., Smith, S. E., Unruh, J., Chen, S., Ward, C., Qian, P., Perry, J. M., et al. (2019) · Cell Reports · doi:10.1016/j.celrep.2018.12.093 · Cited by 146

Advances and challenges in retinoid delivery systems in regenerative and therapeutic medicine

Ferreira, R., Napoli, J., Enver, T., Bernardino, L., & Ferreira, L. (2020) · Nature Communications · doi:10.1038/s41467-020-18042-2 · Cited by 138

The interplay of leukemia cells and the bone marrow microenvironment

Duarte, D., Hawkins, E. D., & Celso, C. L. (2018) · Blood · doi:10.1182/blood-2017-12-784132 · Cited by 135

Losing Sense of Self and Surroundings: Hematopoietic Stem Cell Aging and Leukemic Transformation

Verovskaya, E. V., Dellorusso, P. V., & Passegue, E. A. (2019) · Trends in Molecular Medicine · doi:10.1016/j.molmed.2019.04.006 · Cited by 130

The hematopoietic stem-cell niche in health and leukemia

Sánchez‐Aguilera, A., & Méndez‐Ferrer, S. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2306-y · Cited by 119

Proliferation dynamics of acute myeloid leukaemia and haematopoietic progenitors competing for bone marrow space

Akinduro, O., Weber, T., Ang, H. Y.-K., Haltalli, M. L. R., Ruivo, N., Duarte, D., Rashidi, N. M., Hawkins, E. D., Duffy, K. R., & Celso, C. L. (2018) · Nature Communications · doi:10.1038/s41467-017-02376-5 · Cited by 97

A hostel for the hostile: the bone marrow niche in hematologic neoplasms

Krause, D. S., & Scadden, D. T. (2015) · Haematologica · doi:10.3324/haematol.2014.113852 · Cited by 104

Mammary tumour cells remodel the bone marrow vascular microenvironment to support metastasis

Yip, R. K. H., Rimes, J. S., Capaldo, B. D., Vaillant, F., Mouchemore, K. A., Pal, B., Chen, Y., Surgenor, E. E., Murphy, A. J., Anderson, R. L., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-26556-6 · Cited by 105

Engineering chimeric antigen receptor-T cells for cancer treatment

Ye, B., Stary, C. M., Li, X., Gao, Q., Kang, C., & Xiong, X. (2018) · Molecular Cancer · doi:10.1186/s12943-018-0814-0 · Cited by 95

Leukemia-on-a-chip: Dissecting the chemoresistance mechanisms in B cell acute lymphoblastic leukemia bone marrow niche

Ma, C., Witkowski, M. T., Harris, J., Dolgalev, I., Sreeram, S., Qian, W., Tong, J., Chen, X., Aifantis, I., & Chen, W. (2020) · Science Advances · doi:10.1126/sciadv.aba5536 · Cited by 97

Systemically Infused Mesenchymal Stem Cells Show Different Homing Profiles in Healthy and Tumor Mouse Models

Xie, C., Yang, Z., Suo, Y., Chen, Q., Wei, D., Weng, X., Gu, Z., & Wei, X. (2017) · Stem Cells Translational Medicine · doi:10.1002/sctm.16-0204 · Cited by 85

Mechanisms of extramedullary relapse in acute lymphoblastic leukemia: Reconciling biological concepts and clinical issues

Rouger, J., Jakobczyk, H., Debaize, L., Cousin, É., Galibert, M., Troadec, M., & Gandemer, V. (2019) · Blood Reviews · doi:10.1016/j.blre.2019.04.003 · Cited by 76

CXCR4-mediated signaling regulates autophagy and influences acute myeloid leukemia cell survival and drug resistance

Hu, X., Mei, S., Meng, W., Xue, S., Jiang, L., Yang, Y., Hui, L., Chen, Y., & Guan, M. (2018) · Cancer Letters · doi:10.1016/j.canlet.2018.03.024 · Cited by 73

Bone marrow niche ATP levels determine leukemia-initiating cell activity via P2X7 in leukemic models

He, X., Wan, J., Yang, X., Zhang, X., Huang, D., Xie, L., Zou, Y., Chen, C., Yu, Z., Xie, L., et al. (2020) · Journal of Clinical Investigation · doi:10.1172/jci140242 · Cited by 70

Prophylactic oral NAC reduced poor hematopoietic reconstitution by improving endothelial cells after haploidentical transplantation

Kong, Y., Wang, Y., Zhang, Y., Shi, M.-M., Mo, X., Sun, Y., Chang, Y., Xu, L., Zhang, X., Liu, K., et al. (2019) · Blood Advances · doi:10.1182/bloodadvances.2018029454 · Cited by 67

Atorvastatin enhances bone marrow endothelial cell function in corticosteroid-resistant immune thrombocytopenia patients

Kong, Y., Cao, X.-N., Zhang, X., Shi, M.-M., Lai, Y., Wang, Y., Xu, L., Chang, Y., & Huang, X. (2017) · Blood · doi:10.1182/blood-2017-09-807248 · Cited by 65

Metabolic Imaging Reveals a Unique Preference of Symmetric Cell Division and Homing of Leukemia-Initiating Cells in an Endosteal Niche

Hao, X., Gu, H., Chen, C., Huang, D., Zhao, Y., Xie, L., Zou, Y., Shu, H. S., Zhang, Y., He, X., et al. (2018) · Cell Metabolism · doi:10.1016/j.cmet.2018.11.013 · Cited by 67

Oxidative phosphorylation enhances the leukemogenic capacity and resistance to chemotherapy of B cell acute lymphoblastic leukemia

Chen, C., Hao, X., Lai, X., Liu, L., Zhu, J., Shao, H., Huang, D., Gu, H., Zhang, T., Yu, Z., et al. (2021) · Science Advances · doi:10.1126/sciadv.abd6280 · Cited by 63

The Bone Marrow Microenvironment in Health and Myeloid MalignancyPreprint

Galán-Díez, M., Cuesta‐Domínguez, Á., & Kousteni, S. (2017) · Cold Spring Harbor Perspectives in Medicine · doi:10.1101/cshperspect.a031328 · Cited by 59

Transmissible ER stress reconfigures the AML bone marrow compartment

Doron, B., Abdelhamed, S., Butler, J. T., Hashmi, S. K., Horton, T. M., & Kurre, P. (2018) · Leukemia · doi:10.1038/s41375-018-0254-2 · Cited by 59

Functional Niche Competition Between Normal Hematopoietic Stem and Progenitor Cells and Myeloid Leukemia Cells

Glait‐Santar, C., Desmond, R. G., Feng, X., Bat, T., Chen, J., Heuston, E. F., Mizukawa, B. E., Mulloy, J. C., Bodine, D. M., Larochelle, A., et al. (2015) · Stem Cells · doi:10.1002/stem.2208 · Cited by 55

Long-term in vitro maintenance of clonal abundance and leukaemia-initiating potential in acute lymphoblastic leukaemia

Pal, D., Blair, H., Elder, A., Dormon, K., Rennie, K., Coleman, D. J. L., Weiland, J., Rankin, K. S., Filby, A. J., Heidenreich, O. T., et al. (2016) · Leukemia · doi:10.1038/leu.2016.79 · Cited by 55

Stromal cells promote chemoresistance of acute myeloid leukemia cells via activation of the IL-6/STAT3/OXPHOS axis

Hou, D., Wang, B., You, R., Wang, X., Liu, J., Zhan, W., Chen, P., Qin, T., Zhang, X., & Huang, H. (2020) · Annals of Translational Medicine · doi:10.21037/atm-20-3191 · Cited by 59

Chemotherapy and mismatch repair deficiency cooperate to fuel TP53 mutagenesis and ALL relapse

Yang, F., Brady, S. W., Tang, C. S., Sun, H., Du, L., Barz, M., Ma, X., Chen, Y., Fang, H., Li, X., et al. (2021) · Nature Cancer · doi:10.1038/s43018-021-00230-8 · Cited by 55

Growth differentiation factor 15 contributes to cancer-associated fibroblasts-mediated chemo-protection of AML cells

Zhai, Y., Zhang, J., Wang, H., Lu, W., Liu, S., Yu, Y., Weng, W., Ding, Z., Zhu, Q., & Shi, J. (2016) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-016-0405-0 · Cited by 51

Influence of Bone Marrow Microenvironment on Leukemic Stem Cells

Agarwal, P., & Bhatia, R. (2015) · Advances in cancer research · doi:10.1016/bs.acr.2015.04.007 · Cited by 51

Biomimetic, Hypoxia‐Responsive Nanoparticles Overcome Residual Chemoresistant Leukemic Cells with Co‐Targeting of Therapy‐Induced Bone Marrow Niches

Dong, X., Mu, L., Liu, X., Zhu, H., Yang, S., Lai, X. P., Liu, H., Feng, H., Lu, Q., Zhou, B. S., et al. (2020) · Advanced Functional Materials · doi:10.1002/adfm.202000309 · Cited by 51

The Osteoblastic Niche in Hematopoiesis and Hematological Myeloid Malignancies

Galán-Díez, M., & Kousteni, S. (2017) · Current Molecular Biology Reports · doi:10.1007/s40610-017-0055-9 · Cited by 53

Abundant and equipotent founder cells establish and maintain acute lymphoblastic leukaemia

Elder, A., Bomken, S. N., Wilson, I., Blair, H., Cockell, S., Ponthan, F., Dormon, K., Pal, D., Heidenreich, O. T., & Vormoor, J. H. (2017) · Leukemia · doi:10.1038/leu.2017.140 · Cited by 49

N‐acetyl‐L‐cysteine improves bone marrow endothelial progenitor cells in prolonged isolated thrombocytopenia patients post allogeneic hematopoietic stem cell transplantation

Kong, Y., Shi, M., Zhang, Y., Cao, X.-N., Wang, Y., Zhang, X., Xu, L., & Huang, X. (2018) · American Journal of Hematology · doi:10.1002/ajh.25056 · Cited by 47

Immature CML cells implement a BMP autocrine loop to escape TKI treatment

Grockowiak, É., Laperrousaz, B., Jeanpierre, S., Voeltzel, T., Guyot, B., Gobert, S., Nicolini, F. E., & Maguer‐Satta, V. (2017) · Blood · doi:10.1182/blood-2017-08-801019 · Cited by 46

Mapping and targeting of the leukemic microenvironment

Witkowski, M. T., Kousteni, S., & Aifantis, I. (2019) · The Journal of Experimental Medicine · doi:10.1084/jem.20190589 · Cited by 47

Translational models of tumor angiogenesis: A nexus of in silico and in vitro models

Soleimani, S., Shamsi, M., Ghazani, M. A., Modarres, H. P., Valente, K. P., Saghafian, M., Ashani, M. M., Akbari, M., & Sanati‐Nezhad, A. (2018) · Biotechnology Advances · doi:10.1016/j.biotechadv.2018.01.013 · Cited by 43

An unbalanced monocyte macrophage polarization in the bone marrow microenvironment of patients with poor graft function after allogeneic haematopoietic stem cell transplantation

Zhao, H., Lyu, Z., Duan, C., Song, Y., Han, T., Mo, X., Wang, Y., Xu, L., Zhang, X., Huang, X., et al. (2018) · British Journal of Haematology · doi:10.1111/bjh.15452 · Cited by 43

Adipocytes disrupt the translational programme of acute lymphoblastic leukaemia to favour tumour survival and persistence

Heydt, Q., Xintaropoulou, C., Clear, A. J., Austin, M. J., Pislariu, I., Miraki‐Moud, F., Cutillas, P. R., Korfi, K., Calaminici, M., Cawthorn, W. P., et al. (2021) · Nature Communications · doi:10.1038/s41467-021-25540-4 · Cited by 43

Growth differentiation factor 15 contributes to marrow adipocyte remodeling in response to the growth of leukemic cells

Lu, W., Wan, Y., Li, Z., Zhu, B., Yin, C., Liu, H., Yang, S., Zhai, Y., Yu, Y., Wei, Y., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0738-y · Cited by 41

Therapeutic Antibodies for Myeloid Neoplasms—Current Developments and Future Directions

Schürch, C. M. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00152 · Cited by 42

Dynamic Changes of the Bone Marrow Niche: Mesenchymal Stromal Cells and Their Progeny During Aging and Leukemia

Woods, K., & Guezguez, B. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.714716 · Cited by 42

Leukemic stem cells activate lineage inappropriate signalling pathways to promote their growth

Kellaway, S. G., Potluri, S., Keane, P., Blair, H. J., Ames, L., Worker, A., Chin, P. S., Ptasinska, A., Derevyanko, P. K., Adamo, A., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45691-4 · Cited by 40

Bone marrow infiltrated Lnc-INSR induced suppressive immune microenvironment in pediatric acute lymphoblastic leukemia

Wang, Y., Yang, X., Sun, X., Rong, L., Kang, M., Wu, P., Ji, X., Lin, R., Huang, J., Xue, Y., et al. (2018) · Cell Death and Disease · doi:10.1038/s41419-018-1078-8 · Cited by 38

Sensitizing leukemia stem cells to NF-κB inhibitor treatment in vivo by inactivation of both TNF and IL-1 signaling

Li, J., Volk, A. G., Zhang, J., Cannova, J., Dai, S., Hao, C., Hu, C.-L., Sun, J., Xu, Y., Wei, W., et al. (2016) · Oncotarget · doi:10.18632/oncotarget.14220 · Cited by 38

The BMP pathway: A unique tool to decode the origin and progression of leukemia

Zylbersztejn, F., Flores-Violante, M., Voeltzel, T., Nicolini, F. E., Lefort, S., & Maguer‐Satta, V. (2018) · Experimental Hematology · doi:10.1016/j.exphem.2018.02.005 · Cited by 38

Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia

Chen, Y., Tang, C. S., Zhang, M., Huang, W., Xu, Y. K., Sun, H.-Y., Yang, F., Song, L., Wang, H., Mu, L., et al. (2019) · Leukemia · doi:10.1038/s41375-019-0458-0 · Cited by 37

Bone marrow microenvironment modulation of acute lymphoblastic leukemia phenotype

Moses, B. S., Slone, W. L., Thomas, P., Evans, R., Piktel, D., Angel, P. M., Walsh, C. M., Cantrell, P. S., Rellick, S. L., Martin, K. H., et al. (2015) · Experimental Hematology · doi:10.1016/j.exphem.2015.09.003 · Cited by 37

Generation of Pediatric Leukemia Xenograft Models in NSG-B2m Mice: Comparison with NOD/SCID Mice

Gopalakrishnapillai, A., Kolb, E. A., Dhanan, P., Bojja, A. S., Mason, R. W., Corao, D., & Barwe, S. P. (2016) · Frontiers in Oncology · doi:10.3389/fonc.2016.00162 · Cited by 37

Human natural killer cells: news in the therapy of solid tumors and high-risk leukemias

Pietra, G., Vitale, C., Pende, D., Bertaina, A., Moretta, F., Falco, M., Vacca, P., Montaldo, E., Cantoni, C., Mingari, M. C., et al. (2015) · Cancer Immunology Immunotherapy · doi:10.1007/s00262-015-1744-y · Cited by 36

High cortactin expression in B-cell acute lymphoblastic leukemia is associated with increased transendothelial migration and bone marrow relapse

Velázquez-Avila, M., Balandrán, J. C., Ramírez-Ramírez, D., Velázquez-Avila, M., Sandoval-Cabrera, A., Felipe‐López, A., Nava, P., Alvarado‐Moreno, J. A., Dozal, D., Prieto‐Chávez, J. L., et al. (2018) · Leukemia · doi:10.1038/s41375-018-0333-4 · Cited by 36

THBS1 Is a Novel Serum Prognostic Factors of Acute Myeloid Leukemia

Zhu, L., Li, Q., Wang, X., Liao, J., Zhang, W., Gao, L., Liu, Y. Z., Zhang, C., Zhang, X., Rao, J., et al. (2019) · Frontiers in Oncology · doi:10.2139/ssrn.3401979 · Cited by 35

Osteoclast Cancer Cell Metabolic Cross-talk Confers PARP Inhibitor Resistance in Bone Metastatic Breast Cancer

Fan, H., Xu, Z., Yao, K., Zheng, B., Zhang, Y., Wang, X., Zhang, T., Li, X., Hu, H., Yue, B., et al. (2023) · Cancer Research · doi:10.1158/0008-5472.can-23-1443 · Cited by 40

Image-based RNA interference screening reveals an individual dependence of acute lymphoblastic leukemia on stromal cysteine support

Boutter, J., Huang, Y., Marovca, B., Vonderheit, A., Grotzer, M. A., Eckert, C., Cario, G., Wollscheid, B., Horváth, P., Bornhauser, B. C., et al. (2014) · Oncotarget · doi:10.18632/oncotarget.2572 · Cited by 35

Hypoxia favors chemoresistance in T-ALL through an HIF1α-mediated mTORC1 inhibition loop

Fahy, L., Calvo, J., Chabi, S., Renou, L., Maout, C. L., Poglio, S., Leblanc, T. M., Petit, A., Baruchel, A., Ballerini, P. F., et al. (2021) · Blood Advances · doi:10.1182/bloodadvances.2020002832 · Cited by 35

ARRB1-Promoted NOTCH1 Degradation Is Suppressed by OncomiR miR-223 in T-cell Acute Lymphoblastic Leukemia

Shu, Y., Wang, Y., Lv, W.-Q., Peng, D.-Y., Li, J., Zhang, H., Jiang, G.-J., Yang, B.-J., Liu, S., Zhang, J., et al. (2019) · Cancer Research · doi:10.1158/0008-5472.can-19-1471 · Cited by 34

TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment

Le, B. V., Podszywalow‐Bartnicka, P., Maifrede, S., Sullivan-Reed, K., Nieborowska-Skorska, M., Golovine, K. V., Yao, J.-C., Nejati, R., Cai, K. Q., Caruso, L. B., et al. (2020) · Cell Reports · doi:10.1016/j.celrep.2020.108221 · Cited by 31

Stromal-induced epithelial-mesenchymal transition induces targetable drug resistance in acute lymphoblastic leukemia

Park, C. S., Yoshihara, H., Gao, Q., Qu, C., Iacobucci, I., Ghate, P. S., Connelly, J. P., Pruett‐Miller, S. M., Wagner, B., Robinson, C. G., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.112804 · Cited by 31

Stromal cell-mediated mitochondrial redox adaptation regulates drug resistance in childhood acute lymphoblastic leukemia

Liu, J., Masurekar, A. N., Johnson, S. M., Chakraborty, S., Griffiths, J., Smith, D. L., Alexander, S., Dempsey, C. E., Parker, C. A., Harrison, S., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.5528 · Cited by 30

Metabolic changes underlying drug resistance in the multiple myeloma tumor microenvironment

Montoya, M. M., van Slobbe, G. J. J., Chang, J., Zaal, E. A., & Berkers, C. R. (2023) · Frontiers in Oncology · doi:10.3389/fonc.2023.1155621 · Cited by 33

Mesenchymal Stem Cells With Cancer-Associated Fibroblast-Like Phenotype Stimulate SDF-1/CXCR4 Axis to Enhance the Growth and Invasion of B-Cell Acute Lymphoblastic Leukemia Cells Through Cell-to-Cell Communication

Pan, C., Fang, Q., Liu, P., Ma, D., Cao, S., Zhang, L., Chen, Q., Hu, T., & Wang, J. (2021) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2021.708513 · Cited by 29

Prolonged intracellular accumulation of light-inducible nanoparticles in leukemia cells allows their remote activation

Boto, C., Quartin, E., Cai, Y., Martín-Lorenzo, A., Cenador, M. B. G., Pinto, S., Gupta, R., Enver, T., Sánchez-García, I., Hong, D., et al. (2017) · Nature Communications · doi:10.1038/ncomms15204 · Cited by 28

A non-cell-autonomous role for Pml in the maintenance of leukemia from the niche

Guarnerio, J., Mendez, L., Asada, N., Menon, A. V., Fung, J., Berry, K., Frenette, P. S., Ito, K., & Pandolfi, P. P. (2017) · Nature Communications · doi:10.1038/s41467-017-02427-x · Cited by 27

Leukemia-Induced Cellular Senescence and Stemness Alterations in Mesenchymal Stem Cells Are Reversible upon Withdrawal of B-Cell Acute Lymphoblastic Leukemia Cells

Vanegas, N.-D. P., Ruiz-Aparicio, P. F., Uribe, G. I., Ballesteros, A. L., & Vernot, J. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22158166 · Cited by 26

Chemotherapy-induced niche perturbs hematopoietic reconstitution in B-cell acute lymphoblastic leukemia

Tang, C. S., Li, M., Chen, Y., Sun, H., Liu, S.-L., Zheng, W., Zhang, M., Li, H., Fu, W. E., Zhang, W., et al. (2018) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-018-0859-3 · Cited by 27

Tumor–Stroma Interactions in Bone Metastasis: Molecular Mechanisms and Therapeutic ImplicationsPreprint

Zheng, H., Li, W., & Kang, Y. (2016) · Cold Spring Harbor Symposia on Quantitative Biology · doi:10.1101/sqb.2016.81.030775 · Cited by 25

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Giallongo, S., Duminuco, A., Dulcamare, I., Zuppelli, T., Spina, E. L., Scandura, G., Santisi, A., Romano, A., Raimondo, F. D., Tibullo, D., et al. (2023) · Biomolecules · doi:10.3390/biom13121701 · Cited by 24

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Cao, X.-N., Kong, Y., Song, Y., Shi, M., Zhao, H., Wen, Q., Lyu, Z., Duan, C., Wang, Y., Xu, L., et al. (2018) · British Journal of Haematology · doi:10.1111/bjh.15456 · Cited by 23

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Valent, P., Sadovnik, I., Eisenwort, G., Herrmann, H., Bauer, K., Mueller, N., Sperr, W. R., Wicklein, D., & Schumacher, U. (2019) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2019.07.025 · Cited by 21

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Vanegas, N.-D. P., & Vernot, J. (2017) · Experimental Hematology and Oncology · doi:10.1186/s40164-016-0062-1 · Cited by 23

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Dong, S., & Chen, J. (2015) · BMC Cancer · doi:10.1186/s12885-015-1844-2 · Cited by 20

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Blume, R., Rempel, E., Manta, L., Saeed, B. R., Wang, W., Raffel, S., Ermakova, O. V., Eckstein, V., Beneš, V., Trumpp, A., et al. (2018) · Leukemia & lymphoma/Leukemia and lymphoma · doi:10.1080/10428194.2017.1422862 · Cited by 20

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Huang, X., Ji, M., Shang, X., Zhang, H., Zhang, X., Zhou, J., & Yin, T. (2025) · Journal of Controlled Release · doi:10.1016/j.jconrel.2025.113782 · Cited by 19

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Pal, D., Blair, H. J., Boyd, S., Sharon, A. H., Nizami, S., Isa, A., Beckett, M., Nelson, R., Wilson, A., Singh, M., et al. (2022) · Cell Reports Medicine · doi:10.1016/j.xcrm.2022.100717 · Cited by 19

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(2014) · Cancer Discovery · doi:10.1158/2159-8290.cd-rw2014-135

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