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Peripheral ER structure and function

Open access
English, Amber R, Zurek, Nesia, Voeltz, Gia K·2009·Current Opinion in Cell Biology

Abstract

Summary The endoplasmic reticulum (ER) is a single continuous membrane-enclosed organelle made up of functionally and structurally distinct domains. The ER domains include the nuclear envelope (NE) and the peripheral ER, which is a network of tubules and sheets spread throughout the cytoplasm. The structural organization of the ER is related to its many different cellular functions. Here we will discuss how the various functional domains of the peripheral ER are organized into structurally distinct domains that exist within the continuous membrane bilayer throughout the cell cycle. In addition, we will summarize our current knowledge on how peripheral ER membranes contact various other regions of the cytoplasm including the cytoskeleton, mitochondria, Golgi, and the plasma membrane and what is known about the functions of these interactions.

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Crossref · 10.1016/j.ceb.2009.04.004

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Metadata

Authors
English, A. R., Zurek, N., & Voeltz, G. K.
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2009-08
Volume
21
Issue
4
Pages
596-602
ISSN
0955-0674 (ISSN-L)
OpenAlex
W2092760904
Cited by
186
References
1
FWCI
0.94
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Peripheral ER structure and function. https://app.cochat.ai/papers/10.1016/j.ceb.2009.04.004
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English, A. R., Zurek, N., & Voeltz, G. K. (2009). Peripheral ER structure and function. Current Opinion in Cell Biology. https://doi.org/10.1016/j.ceb.2009.04.004

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.