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Cited by 70Cellular transport and secretionLipid Membrane Structure and BehaviorCaveolin-1 and cellular processes

Mechanochemical crosstalk during endocytic vesicle formation

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Liu, Jian, Sun, Yidi, Oster, George F, Drubin, David G·2010·Current Opinion in Cell Biology
DOI 10.1016/j.ceb.2009.11.009PMC PMC2822040
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Abstract

Membrane curvature has emerged as a key regulatory factor in endocytic vesicle formation. From a theoretical perspective, we summarize recent progress in understanding how membrane curvature and biochemical pathways are coupled and orchestrated during the coherent process of endocytic vesicle formation. We mainly focus on clathrin-mediated and actin-mediated endocytosis in yeast and in mammalian cells. We further speculate on how mechanochemical feedback could modulate other membrane-remodeling processes.

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  • Endocytic proteins such as Synaptojanin 1, Endophilin A, Syndapin 1, and Dynamin 1 can further curve the membrane and generate vesicles.

    “Thereafter, endocytic proteins such as Synaptojanin 1, Endophilin A, Syndapin 1, and Dynamin 1 can further curve the membrane and generate vesicles47–50.”

    From Membrane compression by synaptic vesicle exocytosis triggers ultrafast endocytosis (2023) · cites this paper as [48]

    The section on curvature sensing and sculpting says BAR-domain proteins can bend membranes, and the Dynamin section links dynamin to membrane constriction and vesicle scission. The References discuss endophilin-mediated curvature and synaptojanin 1 in endocytosis, but the copy does not establish that synaptojanin 1 curves membranes or identify Syndapin 1 in this role. It therefore supports the general mechanism, not the full list of named proteins. (LLM, conf=0.86)

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Cited by

Sorted by citations

Authors
Liu, J., Sun, Y., Oster, G. F., & Drubin, D. G.
Affiliations
University of California, Berkeley (US)
Corresponding author
Drubin, David G
ORCID
Venue
Current Opinion in Cell Biology
Publisher
Elsevier BV
Published
2010-02
Volume
22
Issue
1
Pages
36-43
ISSN
0955-0674 (ISSN-L)
DOI
10.1016/j.ceb.2009.11.009
PMC
PMC2822040
OpenAlex
W2033715987
Cited by
70
References
4
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 1 · 2020: 3 · 2019: 2 · 2018: 5 · 2017: 3 · 2016: 2 · 2015: 3 · 2014: 6 · 2013: 10 · 2012: 18
FWCI
0.78
Type
journal article
Language
en
Open access
Licence
Locations
  • Current Opinion in Cell Biology (publishedVersion)
  • PubMed (publishedVersion)
  • PubMed Central (acceptedVersion)
Funders
  • National Science Foundation
  • National Institute of General Medical Sciences (R01GM065462, 1 R01 GM 65462, 1 R01 GM 50399, R01GM042759, R01GM050399, 1 R01 GM 42759, R35GM118149)
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Lipid Membrane Structure and Behavior
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Caveolin-1 and cellular processes
Keywords
membrane curvature, clathrin-mediated endocytosis, membrane remodeling, mechanochemical feedback, yeast, mammalian cells
MeSH terms
Actins, Animals, Clathrin, Endocytosis, Lipid Bilayers, Models, Biological, Signal Transduction, Transport Vesicles, Dynamins

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