Endocytosis and signaling: Cell logistics shape the eukaryotic cell plan
Open accessAbstract
Our understanding of endocytosis has evolved remarkably in little more than a decade. This is the result not only of advances in our knowledge of its molecular and biological workings, but also of a true paradigm shift in our understanding of what really constitutes endocytosis and of its role in homeostasis. Although endocytosis was initially discovered and studied as a relatively simple process to transport molecules across the plasma membrane, it was subsequently found to be inextricably linked with almost all aspects of cellular signaling. This led to the notion that endocytosis is actually the master organizer of cellular signaling, providing the cell with understandable messages that have been resolved in space and time. In essence, endocytosis provides the communications and supply routes (the logistics) of the cell. Although this may seem revolutionary, it is still likely to be only a small part of the entire story. A wealth of new evidence is uncovering the surprisingly pervasive nature of endocytosis in essentially all aspects of cellular regulation. In addition, many newly discovered functions of endocytic proteins are not immediately interpretable within the classical view of endocytosis. A possible framework, to rationalize all this new knowledge, requires us to “upgrade” our vision of endocytosis. By combining the analysis of biochemical, biological, and evolutionary evidence, we propose herein that endocytosis constitutes one of the major enabling conditions that in the history of life permitted the development of a higher level of organization, leading to the actuation of the eukaryotic cell plan.
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Endocytosis provides a special route of cellular trafficking and signal transduction.
“Earlier, the endocytosis process was exclusively attributed to the internalization of molecules across the plasma membrane, but with the methodological advancement, it has been found that endocytosis is providing a special route of cellular trafficking and signal transduction [4].”
From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [4]
Many cellular signaling events govern through internalization of plasma membrane receptor endocytosis signaling to coordinate the network between extracellular and intracellular environment.
“Many cellular signaling events govern through internalization of plasma membrane receptor endocytosis signaling to coordinate the network between the extracellular and intracellular environment [4].”
From Insights of Endocytosis Signaling in Health and Disease (2023) · cites this paper as [4]
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“The endocytic signaling is further regulated and modulated by several intracellular proteins [4].”
BackgroundInfluentialCD13 Restricts TLR4 Endocytic Signal Transduction in Inflammation
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Epithelial-to-Mesenchymal Plasticity Harnesses Endocytic Circuitries
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Self-citationConstitutive Endocytosis of VEGFR2 Protects the Receptor against Shedding
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Chapter Six - The Ubiquitin Network in the Control of EGFR Endocytosis and Signaling
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- Authors
- Sigismund, S., Confalonieri, S., Ciliberto, A., Polo, S., Scita, G., & Di Fiore, P. P.
- Affiliations
- University of Milan (IT)
- IFOM, Fondazione Istituto FIRC di Oncologia Molecolare; Dipartimento di Medicina, Chirurgia ed Odontoiatria, Universita' degli Studi di Milano; and Istituto Europeo di Oncologia, Milan, Italy
- Venue
- Physiological Reviews
- Publisher
- American Physiological Society
- Published
- 2012-01
- Volume
- 92
- Issue
- 1
- Pages
- 273-366
- ISSN
- 0031-9333 (ISSN-L)
- 1522-1210
- PMC
- PMC5614474
- OpenAlex
- W2068807411
- Cited by
- 338
- References
- 900
- Citations by year
- 2026: 9 · 2025: 13 · 2024: 18 · 2023: 33 · 2022: 18 · 2021: 16 · 2020: 25 · 2019: 25 · 2018: 30 · 2017: 26 · 2016: 30 · 2015: 21 · 2014: 31 · 2013: 28 · 2012: 14
- FWCI
- 2.78
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- Physiological Reviews (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Cellular transport and secretion
- Health Sciences › Medicine › Epidemiology › Autophagy in Disease and Therapy
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Keywords
- endocytosis, signal transduction, plasma membrane transport, homeostasis, endocytic proteins, cell organization
- MeSH terms
- Animals, Cell Communication, Endocytosis, Eukaryotic Cells, Biological Evolution, Hemostasis, Humans, Signal Transduction
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