The DOI matches its Crossref record; 170 of the 171 references it cites were found in a registry or an index.
mTOR signaling in disease
Abstract
The target of rapamycin (TOR) is a highly conserved serine/threonine kinase and a central controller of cell growth, metabolism and aging. Mammalian TOR (mTOR) is activated in response to nutrients, growth factors and cellular energy. Dysregulated mTOR signaling has been implicated in major disease. Here we review recent findings on the role of mTOR in cancer, metabolic disorders, neurological diseases, and inflammation.
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“Signaling via mTOR is linked to accelerated aging and dysregulation of mTOR signaling is also linked to the progression of cancer, inflammatory and neurological diseases, as well as T2DM (59).”
From A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan (2021) · cites this paper as [59]
Citations
Cites
1 retracted
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RetractedHallmarks of Cancer: The Next Generation
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Mutations of the BRAF gene in human cancer
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TOR signaling in growth and metabolism
Wullschleger, S., Loewith, R., & Hall, M. N. (2006) · Cell · doi:10.1016/j.cell.2006.01.016 · Cited by 5,787
Sorafenib in Advanced Hepatocellular Carcinoma
정, 재. (2008) · Cited by 5,586
ras oncogenes in human cancer: a review.
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Morice, M., Serruys, P. W. J. C., Sousa, J. E., Fajadet, J. C., Hayashi, E. B., Perin, M. A., Colombo, A., Schuler, G. C., Barragan, P. T., Guagliumi, G., et al. (2002) · New England Journal of Medicine · doi:10.1056/nejmoa012843 · Cited by 4,028
mTOR: from growth signal integration to cancer, diabetes and ageing
Zoncu, R., Efeyan, A., & Sabatini, D. M. (2011) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm3025 · Cited by 3,941
Cited by
Sorted by citations
Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c
Hagiwara, A., Cornu, M., Cybulski, N., Polak, P., Betz, C., Trapani, F., Terracciano, L., Heim, M. H., Rüegg, M. A., & Hall, M. N. (2012) · Cell Metabolism · doi:10.1016/j.cmet.2012.03.015 · Cited by 585
Quantitative Phosphoproteomics Reveal mTORC1 Activates de Novo Pyrimidine Synthesis
Robitaille, A. M., Christen, S., Shimobayashi, M., Cornu, M., Fava, L. L., Moes, S., Prescianotto-Baschong, C., Sauer, U., Jenoe, P., & Hall, M. N. (2013) · Science · doi:10.1126/science.1228771 · Cited by 525
Where is mTOR and what is it doing there?
Betz, C., & Hall, M. N. (2013) · The Journal of Cell Biology · doi:10.1083/jcb.201306041 · Cited by 533
SREBPs: metabolic integrators in physiology and metabolism
Jeon, T.-I., & Osborne, T. F. (2012) · Trends in Endocrinology & Metabolism · doi:10.1016/j.tem.2011.10.004 · Cited by 464
Mechanisms of Cardiac and Renal Dysfunction in Patients Dying of Sepsis
Takasu, O., Gaut, J. P., Watanabe, E., To, K. B., Fagley, R. E., Sato, B., Jarman, S., Efimov, I. R., Janks, D., Srivastava, A., et al. (2013) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.201211-1983oc · Cited by 529
Metadata
- Authors
- Dazert, E., & Hall, M. N.
- Affiliations
- University of Basel (CH)
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 23
- Issue
- 6
- Pages
- 744-755
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2076457380
- Cited by
- 460
- References
- 171
- Citations by year
- 2026: 10 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 24 · 2021: 26 · 2020: 18 · 2019: 19 · 2018: 38 · 2017: 34 · 2016: 34 · 2015: 38 · 2014: 65 · 2013: 51 · 2012: 54
- FWCI
- 5.11
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Louis-Jeantet Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › PI3K/AKT/mTOR signaling in cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Metabolism, Diabetes, and Cancer
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Autophagy in Disease and Therapy
- Keywords
- mTOR signaling, mammalian target of rapamycin, serine/threonine kinase, cell growth regulation, metabolism, aging, cancer, metabolic disorders, neurological disorders, inflammation, nutrient sensing
- MeSH terms
- Animals, Disease Models, Animal, Humans, Mammals, Neoplasms, Signal Transduction, Cell Proliferation, TOR Serine-Threonine Kinases
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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