Reprogramming development and aging: cell differentiation as a malleable process
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Full expression of the Yamanaka factors (OCT4, SOX2, KLF4 and MYC (OSKM)) in differentiated cells results in induction of pluripotency and a resetting of cellular ageing characteristics.
“Full expression of the Yamanaka factors (OCT4, SOX2, KLF4 and MYC (OSKM)) in differentiated cells results in induction of pluripotency (induced pluripotent stem cells) and a resetting of cellular ageing characteristics223–225.”
From Ageing and rejuvenation of tissue stem cells and their niches (2023) · cites this paper as [224]
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Ageing and rejuvenation of tissue stem cells and their niches
Brunet, A., Goodell, M. A., & Rando, T. A. (2023) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-022-00510-w · Cited by 407 · see citing works
Epigenetics of Aging and Aging-related Disease
Brunet, A., & Berger, S. L. (2014) · The Journals of Gerontology Series A · doi:10.1093/gerona/glu042 · Cited by 263 · see citing works
Current Advances in Corneal Stromal Stem Cell Biology and Therapeutic Applications
Volatier, T. L. A., Cursiefen, C., & Notara, M. (2024) · Cells · doi:10.3390/cells13020163 · Cited by 22 · see citing works
Reprogramming by lineage specifiers: blurring the lines between pluripotency and differentiation
Sancho-Martinez, I., Ocampo, A., & Belmonte, J. C. I. (2014) · Current Opinion in Genetics & Development · doi:10.1016/j.gde.2014.09.009 · Cited by 6 · see citing works
“The cells present in the ICM, defined as pluripotent stem cells (PSCs), give rise to all three different germ cell layers of the embryo and ultimately, the adult individual [1 ,2].”
BackgroundSelf-citationValdespino, V., Valdespino-Castillo, P. M., & Junio, V. V. (2013) · American Journal of Biomedical Research · doi:10.12691/ajbr-1-3-2 · Cited by 1 · see citing works
- Authors
- Izpisua Belmonte, J. C.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2012-12
- Volume
- 24
- Issue
- 6
- Pages
- 713-715
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2034765014
- Cited by
- 5
- References
- 0
- Citations by year
- 2024: 1 · 2022: 1 · 2014: 2 · 2013: 1
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Current Opinion in Cell Biology (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Keywords
- induced pluripotent stem cells, pluripotency, cell differentiation, cellular reprogramming, aging, developmental reprogramming, in vitro culture conditions, regenerative medicine
- MeSH terms
- Aging, Cell Differentiation, Humans, Rejuvenation, Induced Pluripotent Stem Cells, Cellular Reprogramming
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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