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Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking
Open accessAbstract
The arrestin clan can now be broadly divided into three structurally similar subgroups: the originally identified arrestins (visual and β-arrestins), the α-arrestins and a group of Vps26-related proteins. The visual and β-arrestins selectively bind to agonist-occupied phosphorylated G protein-coupled receptors (GPCRs) and inhibit GPCR coupling to heterotrimeric G proteins while the β-arrestins also function as adaptor proteins to regulate GPCR trafficking and G protein-independent signaling. The α-arrestins have also recently been implicated in regulating GPCR trafficking while Vps26 regulates retrograde trafficking. In this review, we provide an overview of the α- and β-arrestins with a focus on our current understanding of how these adaptor proteins regulate GPCR trafficking.
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Cites
Dishevelled 2 Recruits ß-Arrestin 2 to Mediate Wnt5A-Stimulated Endocytosis of Frizzled 4
Chen, W., ten Berge, D., Brown, J., Ahn, S., Hu, L. A., Miller, W. E., Caron, M. G., Barak, L. S., Nusse, R., & Lefkowitz, R. J. (2003) · Science · doi:10.1126/science.1082808 · Cited by 334
Cited by
The β-Arrestins: Multifunctional Regulators of G Protein-coupled Receptors
Smith, J. S., & Rajagopal, S. (2016) · Journal of Biological Chemistry · doi:10.1074/jbc.r115.713313 · Cited by 294
Organelle proteomic profiling reveals lysosomal heterogeneity in association with longevity
Yu, Y., Gao, S. M., Guan, Y., Hu, P.-W., Zhang, Q., Liu, J., Jing, B., Zhao, Q., Sabatini, D. M., Abu-Remaileh, M., et al. (2024) · eLife · doi:10.7554/elife.85214 · Cited by 37
GRKs and β-Arrestins: “Gatekeepers” of Mitochondrial Function in the Failing Heart
Sorriento, D., Gambardella, J., Fiordelisi, A., Iaccarino, G., & Illario, M. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00064 · Cited by 16
Zhang, X.-Q., Li, X.-R., Ren, J., Li, Y.-B., Cai, M.-J., Wang, J.-X., & Zhao, X.-F. (2015) · Cellular Signalling · doi:10.1016/j.cellsig.2015.01.016 · Cited by 7
Metadata
- Authors
- Kang, D. S., Tian, X., & Benovic, J. L.
- Venue
- Current Opinion in Cell Biology
- Publisher
- Elsevier BV
- Published
- 2014-04
- Volume
- 27
- Pages
- 63-71
- ISSN
- 0955-0674 (ISSN-L)
- OpenAlex
- W2076071077
- Cited by
- 191
- References
- 1
- FWCI
- 1.30
- Type
- journal article
- Language
- en
- Open access
- green
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- Kang, D. S., Tian, X., & Benovic, J. L. (2014). Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking. Current Opinion in Cell Biology. https://doi.org/10.1016/j.ceb.2013.11.005
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