Intracellular Ca2+ signaling and Ca2+ microdomains in the control of cell survival, apoptosis and autophagy

Modulation of intracellular calcium homeostasis blocks autophagosome formation

Engedal, N., Torgersen, M. L., Guldvik, I. J., Barfeld, S. J., Bakula, D., Sætre, F., Hagen, L. K., Patterson, J. B., Proikas-Cezanne, T., Seglen, P. O., et al. (2013) · Autophagy · doi:10.4161/auto.25900 · Cited by 104

TRP‐ML1 functions as a lysosomal NAADP‐sensitive Ca2+ release channel in coronary arterial myocytes

Zhang, F., Jin, S., Yi, F., & Li, P. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00486.x · Cited by 102

Role of the inositol 1,4,5-trisphosphate receptor/Ca2+-release channel in autophagy

Parys, J. B., Decuypere, J.-P., & Bultynck, G. (2012) · Cell Communication and Signaling · doi:10.1186/1478-811x-10-17 · Cited by 101

Interplay Between Intracellular Ca2+ Oscillations and Ca2+-stimulated Mitochondrial Metabolism

Wacquier, B., Combettes, L., Nhieu, G. T. V., & Dupont, G. (2016) · Scientific Reports · doi:10.1038/srep19316 · Cited by 101

Omegasomes: PI3P platforms that manufacture autophagosomes

Roberts, R. L., & Ktistakis, N. T. (2013) · Essays in Biochemistry · doi:10.1042/bse0550017 · Cited by 98

The C Terminus of Bax Inhibitor-1 Forms a Ca2+-permeable Channel Pore

Bultynck, G., Kiviluoto, S., Henke, N., Ivanova, H., Schneider, L., Rybalchenko, V., Luyten, T., Nuyts, K., Borggraeve, W. M. D., Борисович, Б. И., et al. (2011) · Journal of Biological Chemistry · doi:10.1074/jbc.m111.275354 · Cited by 97

Mitochondrial Ca2+ influx targets cardiolipin to disintegrate respiratory chain complex II for cell death induction

Hwang, M.-S., Schwall, C. T., Pazarentzos, E., Datler, C., Alder, N. N., & Grimm, S. (2014) · Cell Death and Differentiation · doi:10.1038/cdd.2014.84 · Cited by 96

Role of Inositol Trisphosphate Receptors in Autophagy in DT40 Cells

Khan, M. T. M., & Joseph, S. K. (2010) · Journal of Biological Chemistry · doi:10.1074/jbc.m110.114207 · Cited by 95

Intravital imaging reveals p53-dependent cancer cell death induced by phototherapy via calcium signaling

Giorgi, C., Bonora, M., Missiroli, S., Poletti, F., Ramírez, F. G., Morciano, G., Morganti, C., Pandolfi, P. P., Mammano, F., & Pinton, P. (2014) · Oncotarget · doi:10.18632/oncotarget.2935 · Cited by 93

Perturbed mitochondrial Ca2+signals as causes or consequences of mitophagy induction

Rimessi, A., Bonora, M., Marchi, S., Patergnani, S., Marobbio, C. M. T., Lasorsa, F. M., & Pinton, P. (2013) · Autophagy · doi:10.4161/auto.24795 · Cited by 92

Mitochondrial apoptosis without VDAC

Galluzzi, L., & Kroemer, G. (2007) · Nature Cell Biology · doi:10.1038/ncb0507-487 · Cited by 91

The regulatory domain of the inositol 1,4,5-trisphosphate receptor is necessary to keep the channel domain closed: possible physiological significance of specific cleavage by caspase 3

Nakayama, T., Hattori, M., Uchida, K., Nakamura, T., Tateishi, Y., Bannai, H., Iwai, M., Michikawa, T., Inoue, T., & Mikoshiba, K. (2004) · Biochemical Journal · doi:10.1042/bj20030599 · Cited by 89

Bcl-2 interaction with the inositol 1,4,5-trisphosphate receptor: Role in Ca2+ signaling and disease

Distelhorst, C., & Bootman, M. D. (2011) · Cell Calcium · doi:10.1016/j.ceca.2011.05.011 · Cited by 88

Mitochondrial Ca2+ uptake by the voltage-dependent anion channel 2 regulates cardiac rhythmicity

Shimizu, H., Schredelseker, J., Huang, J., Lu, K., Naghdi, S., Lu, F., Franklin, S., Fiji, H. D. G., Wang, K., Zhu, H., et al. (2015) · eLife · doi:10.7554/elife.04801 · Cited by 88

Characteristics and requirements of basal autophagy in HEK 293 cells

Musiwaro, P., Smith, M. D., Manifava, M., Walker, S. A., & Ktistakis, N. T. (2013) · Autophagy · doi:10.4161/auto.25455 · Cited by 87

Lysosomal Two-pore Channel Subtype 2 (TPC2) Regulates Skeletal Muscle Autophagic Signaling

Lin, P., Duann, P., Komazaki, S., Park, K. H., Li, H., Sun, M., Sermersheim, M., Gumpper, K., Parrington, J., Galione, A., et al. (2014) · Journal of Biological Chemistry · doi:10.1074/jbc.m114.608471 · Cited by 87

A novel Ca2+-mediated cross-talk between endoplasmic reticulum and acidic organelles: Implications for NAADP-dependent Ca2+ signalling

Ronco, V., Potenza, D. M., Denti, F., Vullo, S., Gagliano, G., Tognolina, M., Guerra, G., Pinton, P., Genazzani, A. A., Mapelli, L., et al. (2015) · Cell Calcium · doi:10.1016/j.ceca.2015.01.001 · Cited by 87

TMBIM3/GRINA is a novel unfolded protein response (UPR) target gene that controls apoptosis through the modulation of ER calcium homeostasis

Rojas‐Rivera, D., Armisén, R., Colombo, A., Martínez, G., Eguiguren, A. L., Díaz, A., Kiviluoto, S., Rodríguez, D. A., Patrón, M., Rizzuto, R., et al. (2012) · Cell Death and Differentiation · doi:10.1038/cdd.2011.189 · Cited by 86

Endolysosomal two‐pore channels regulate autophagy in cardiomyocytes

García‐Rúa, V., Feijóo‐Bandín, S., Rodríguez‐Penas, D., Mosquera‐Leal, A., Abu‐Assi, E., Beiras, A., Seoane, L. M., Lear, P., Parrington, J., Portolés, M., et al. (2016) · The Journal of Physiology · doi:10.1113/jp271332 · Cited by 85

Regulators of Calcium Homeostasis Identified by Inference of Kinetic Model Parameters from Live Single Cells Perturbed by siRNA

Bandara, S., Malmersjö, S., & Meyer, T. (2013) · Science Signaling · doi:10.1126/scisignal.2003649 · Cited by 79

VDAC1-based peptides: novel pro-apoptotic agents and potential therapeutics for B-cell chronic lymphocytic leukemia

Prezma, T., Shteinfer‐Kuzmine, A., Admoni, L., Raviv, Z., Sela, I., Levi, I., & Shoshan‐Barmatz, V. (2013) · Cell Death and Disease · doi:10.1038/cddis.2013.316 · Cited by 78

Ryanodine receptor calcium release channels: lessons from structure–function studies

Amador, F. J., Stathopulos, P. B., Enomoto, M., & Ikura, M. (2013) · FEBS Journal · doi:10.1111/febs.12194 · Cited by 73

Coupling acidic organelles with the ER through Ca2+ microdomains at membrane contact sites

Penny, C. J., Kilpatrick, B. S., Eden, E. R., & Patel, S. (2015) · Cell Calcium · doi:10.1016/j.ceca.2015.03.006 · Cited by 72

A computational model of lysosome-ER Ca2+ microdomains

Penny, C. J., Kilpatrick, B. S., Han, J. M., Sneyd, J., & Patel, S. (2014) · Journal of Cell Science · doi:10.1242/jcs.149047 · Cited by 69

A synthetic peptide targeting the BH4 domain of Bcl-2 induces apoptosis in multiple myeloma and follicular lymphoma cells alone or in combination with agents targeting the BH3-binding pocket of Bcl-2

Lavik, A. R., Zhong, F., Chang, M.-J., Greenberg, E. F., Choudhary, Y., Smith, M. R., McColl, K. S., Pink, J. J., Reu, F. J., Matsuyama, S., et al. (2015) · Oncotarget · doi:10.18632/oncotarget.4489 · Cited by 67

Both RyRs and TPCs are required for NAADP-induced intracellular Ca2+ release

Gerasimenko, J. V., Charlesworth, M. R., Sherwood, M. W., Ferdek, P. E., Mikoshiba, K., Parrington, J., Petersen, O. H., & Gerasimenko, O. V. (2015) · Cell Calcium · doi:10.1016/j.ceca.2015.05.005 · Cited by 66

Human Golgi Antiapoptotic Protein Modulates Intracellular Calcium Fluxes

de Mattia, F., Keller, C. G., van Dommelen, M. M. T., Visch, H.-J., Distelmaier, F., Postigo, A. A., Luyten, T., Parys, J. B., SMEDT, H. D., Smith, G. L., et al. (2009) · Molecular Biology of the Cell · doi:10.1091/mbc.e09-05-0385 · Cited by 65

Reduced mitochondrial Ca2+ transients stimulate autophagy in human fibroblasts carrying the 13514A>G mutation of the ND5 subunit of NADH dehydrogenase

Granatiero, V., Giorgio, V., Calí, T., Patrón, M., Brini, M., Bernardi, P., Tiranti, V., Zeviani, M., Pallafacchina, G., Stefani, D. D., et al. (2015) · Cell Death and Differentiation · doi:10.1038/cdd.2015.84 · Cited by 62

Molecular diversity and pleiotropic role of the mitochondrial calcium uniporter

Murgia, M., & Rizzuto, R. (2014) · Cell Calcium · doi:10.1016/j.ceca.2014.11.001 · Cited by 59

Targeted siRNA Screens Identify ER-to-Mitochondrial Calcium Exchange in Autophagy and Mitophagy Responses in RPE1 Cells

MacVicar, T., Mannack, L., Lees, R. M., & Lane, J. D. (2015) · International Journal of Molecular Sciences · doi:10.3390/ijms160613356 · Cited by 59

Calcium homoeostasis modulator 1 (CALHM1) reduces the calcium content of the endoplasmic reticulum (ER) and triggers ER stress

Gallego‐Sandín, S., Alonso, M. T., & García-Sancho, J. (2011) · Biochemical Journal · doi:10.1042/bj20110479 · Cited by 54

Synergistic killing of human small cell lung cancer cells by the Bcl-2-inositol 1,4,5-trisphosphate receptor disruptor BIRD-2 and the BH3-mimetic ABT-263

Greenberg, E. F., McColl, K. S., Zhong, F., Wildey, G. M., Dowlati, A., & Distelhorst, C. W. (2015) · Cell Death and Disease · doi:10.1038/cddis.2015.355 · Cited by 53

The mitochondrial calcium uniporter: Mice can live and die without it

Harrington, J., & Murphy, E. (2014) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2014.10.013 · Cited by 52

Aberrant calcium signaling by transglutaminase-mediated posttranslational modification of inositol 1,4,5-trisphosphate receptors

Hamada, K., Terauchi, A., Nakamura, K., Higo, T., Nukina, N., Matsumoto, N., Hisatsune, C., Nakamura, T., & Mikoshiba, K. (2014) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1409730111 · Cited by 49

Intracellular calcium channels: Inositol-1,4,5-trisphosphate receptors

Fedorenko, O. A., Александровна, П. Е., Enomoto, M., Stathopulos, P. B., Ikura, M., & Борисович, Б. И. (2013) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2013.10.074 · Cited by 48

Cytoplasmic nanojunctions between lysosomes and sarcoplasmic reticulum are required for specific calcium signaling

Fameli, N., Ogunbayo, O. A., van Breemen, C., & Evans, A. M. (2014) · F1000Research · doi:10.12688/f1000research.3720.1 · Cited by 48

Rapid Recycling of Ca2+ between IP3-Sensitive Stores and Lysosomes

López-Sanjurjo, C. I., Tovey, S. C., & Taylor, C. W. (2014) · PLoS ONE · doi:10.1371/journal.pone.0111275 · Cited by 47

Bcl-2 regulation of the inositol 1,4,5-trisphosphate receptor and calcium signaling in normal and malignant lymphocytes: Potential new target for cancer treatment

Greenberg, E. F., Lavik, A. R., & Distelhorst, C. (2014) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2014.03.008 · Cited by 47

Mitigation of postischemic cardiac contractile dysfunction by CaMKII inhibition: effects on programmed necrotic and apoptotic cell death

Szobi, A., Rajtík, T., Čarnická, S., Ravíngerová, T., & Adameová, A. (2013) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-013-1918-x · Cited by 44

Ca2+, autophagy and protein degradation: Thrown off balance in neurodegenerative disease

Vicencio, J. M., Lavandero, S., & Szabadkai, G. (2010) · Cell Calcium · doi:10.1016/j.ceca.2009.12.013 · Cited by 44

Exploring the biophysical evidence that mammalian two‐pore channels are NAADP‐activated calcium‐permeable channels

Pitt, S. J., Reilly-O’Donnell, B., & Sitsapesan, R. M. (2016) · The Journal of Physiology · doi:10.1113/jp270936 · Cited by 44

LRRK2 at the Crossroad Between Autophagy and Microtubule Trafficking: Insights into Parkinson’s Disease

Esteves, A. R., & Cardoso, S. M. (2016) · The Neuroscientist · doi:10.1177/1073858415616558 · Cited by 43

TPC: the NAADP discovery channel?

Morgan, A. J., Davis, L. C., Ruas, M., & Galione, A. (2015) · Biochemical Society Transactions · doi:10.1042/bst20140300 · Cited by 43

Endoplasmic reticulum Ca2+ content decrease by PKA-dependent hyperphosphorylation of type 1 IP3 receptor contributes to prostate cancer cell resistance to androgen deprivation

Boutin, B., Tajeddine, N., Monaco, G., et al. (2015) · Cell Calcium · doi:10.1016/j.ceca.2015.02.004 · Cited by 42

p53 and Ca2+ signaling from the endoplasmic reticulum: partners in anti-cancer therapies

Bittremieux, M., & Bultynck, G. (2015) · Oncoscience · doi:10.18632/oncoscience.139 · Cited by 39

The calcium-signaling toolkit: Updates needed

Dubois, C., Prevarskaya, N. B., & Abeele, F. V. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.11.033 · Cited by 36

Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis

Kiviluoto, S., Luyten, T., Schneider, L., Lisak, D. A., Rojas‐Rivera, D., Welkenhuyzen, K., Missaen, L., SMEDT, H. D., Parys, J. B., Hetz, C. A., et al. (2013) · Cell Calcium · doi:10.1016/j.ceca.2013.06.002 · Cited by 35

ITPRs/inositol 1,4,5-trisphosphate receptors in autophagy: From enemy to ally

Decuypere, J.-P., Parys, J. B., & Bultynck, G. (2015) · Autophagy · doi:10.1080/15548627.2015.1083666 · Cited by 35

Onco-IP 3 Rs Feed Cancerous Cravings for Mitochondrial Ca 2+

Bultynck, G. (2016) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2016.03.006 · Cited by 32

Ca2+–Sensor Proteins in the Autophagic and Endocytic Traffic

Ghislat, G., & Knecht, E. (2013) · Current Protein and Peptide Science · doi:10.2174/13892037112139990033 · Cited by 28

Ca 2+ microdomains, NAADP and type 1 ryanodine receptor in cell activation

Guse, A. H., & Wolf, I. M. A. (2016) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2016.01.014 · Cited by 20

The roles of IP3 receptor in energy metabolic pathways and reactive oxygen species homeostasis revealed by metabolomic and biochemical studies

Wen, H., Xu, W. J., Jin, X. Y., Oh, S., Phan, C. H. D., Song, J., Lee, S. K., & Park, S. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular Cell Research · doi:10.1016/j.bbamcr.2015.07.020 · Cited by 19

The symphony of autophagy and calcium signaling

Yao, Z., & Klionsky, D. J. (2015) · Autophagy · doi:10.1080/15548627.2015.1058475 · Cited by 9

Ca2+ Transfer from the ER to Mitochondria: Channeling Cell Death by a Tumor Suppressor

Jones, A. W. E., & Szabadkai, G. (2010) · Developmental Cell · doi:10.1016/j.devcel.2010.11.013 · Cited by 8

Physiology of Astroglia

Verkhratsky, A., & Nedergaard, M. (2018) · Physiological Reviews · doi:10.1152/physrev.00042.2016 · Cited by 1,678

Autophagy, Inflammation, and Immune Dysfunction in the Pathogenesis of Pancreatitis

Gukovskaya, A. S., Gukovsky, I., Algül, H., & Habtezion, A. (2017) · Gastroenterology · doi:10.1053/j.gastro.2017.08.071 · Cited by 357

Mitochondria‐associated endoplasmic reticulum membrane: Overview and inextricable link with cancer

Yang, X., Zhuang, J., Song, W., Shen, W., Wu, W., Shen, H., & Han, S. (2023) · Journal of Cellular and Molecular Medicine · doi:10.1111/jcmm.17696 · Cited by 55

Impaired calcium signaling in muscle fibers from intercostal and foot skeletal muscle in a cigarette smoke-induced mouse model of COPD: E-C Coupling Dysfunction in COPD

Robison, P., Sussan, T. E., Chen, H., Biswal, S., Schneider, M. F., & Hernández-Ochoa, E. O. (2017) · Muscle & Nerve · doi:10.1002/mus.25466 · Cited by 14