Cited by 81Hydrogels: synthesis, properties, applicationsNanoparticle-Based Drug DeliveryAdvanced Drug Delivery Systems

The DOI matches its Crossref record; 56 of the 56 references it cites were found in a registry or an index.

Multifunctional drug-loaded micelles encapsulated in thermo-sensitive hydrogel for in vivo local cancer treatment: Synergistic effects of anti-vascular and immuno-chemotherapy

Fentahun Darge, Haile, Yibru Hanurry, Endiries, Simegniew Birhan, Yihenew, Worku Mekonnen, Tefera, Tizazu Andrgie, Abegaz, Chou, Hsiao-Ying, Lai, Juin-Yih, Tsai, Hsieh-Chih·2021·Chemical Engineering Journal

DOI 10.1016/j.cej.2020.126879

Open this paper in CoChat — free account

Integrity signals

Registry

Crossref · 10.1016/j.cej.2020.126879

Cites

56 of 56 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

We couldn’t retrieve this paper’s full text, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Designing hydrogels for controlled drug delivery
Li, J., & Mooney, D. J. (2016) · Nature Reviews Materials · doi:10.1038/natrevmats.2016.71 · Cited by 5,069
Global patterns of cancer incidence and mortality rates and trends
Jemal, A., Center, M. M., DeSantis, C., & Ward, E. M. (2010) · Cancer Epidemiology, Biomarkers & Prevention · doi:10.1158/1055-9965.epi-10-0437 · Cited by 2,778
Doxorubicin: an update on anticancer molecular action, toxicity and novel drug delivery systems
Tacar, O., Sriamornsak, P., & Dass, C. R. (2012) · Journal of Pharmacy and Pharmacology · doi:10.1111/j.2042-7158.2012.01567.x · Cited by 2,528
Current Challenges in Cancer Treatment
Zugazagoitia, J., Guedes, C., Ponce, S., Ferrer, I., Molina‐Pinelo, S., & Paz-Ares, L. G. (2016) · Clinical Therapeutics · doi:10.1016/j.clinthera.2016.03.026 · Cited by 961
Polymeric micelle stability
Owen, S. C., Chan, D. P. Y., & Shoichet, M. S. (2012) · Nano Today · doi:10.1016/j.nantod.2012.01.002 · Cited by 911
Enhanced anti-tumor efficacy by co-delivery of doxorubicin and paclitaxel with amphiphilic methoxy PEG-PLGA copolymer nanoparticles
Wang, H., Zhao, Y., Wu, Y. F., Hu, Y.-L., Nan, K., Nie, G., & Chen, H. (2011) · Biomaterials · doi:10.1016/j.biomaterials.2011.07.032 · Cited by 603
Improving cellular uptake of therapeutic entities through interaction with components of cell membrane
Zhang, R., Qin, X., Kong, F., Chen, P., & Pan, G. (2019) · Drug Delivery · doi:10.1080/10717544.2019.1582730 · Cited by 383
Multifunctional Gold Nanostar Conjugates for Tumor Imaging and Combined Photothermal and Chemo-therapy
Chen, H., Zhang, X., Dai, S., Ma, Y., Cui, S., Achilefu, S. A., & Gu, Y. (2013) · Theranostics · doi:10.7150/thno.6630 · Cited by 226
Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining
Pietkiewicz, S., Schmidt, J. H., & Lavrik, I. N. (2015) · Journal of Immunological Methods · doi:10.1016/j.jim.2015.04.025 · Cited by 224
DMXAA Causes Tumor Site-Specific Vascular Disruption in Murine Non-Small Cell Lung Cancer, and like the Endogenous Non-Canonical Cyclic Dinucleotide STING Agonist, 2′3′-cGAMP, Induces M2 Macrophage Repolarization
Downey, C. M., Aghaei, M., Schwendener, R. A., & Jirik, F. R. (2014) · PLoS ONE · doi:10.1371/journal.pone.0099988 · Cited by 197
A Hyaluronidase-Responsive Nanoparticle-Based Drug Delivery System for Targeting Colon Cancer Cells
Zhang, M., Xu, C., Wen, L., Han, M. K., Xiao, B., Zhou, J., Zhang, Y., Zhang, Z., Viennois, É., & Merlin, D. (2016) · Cancer Research · doi:10.1158/0008-5472.can-16-1681 · Cited by 172
Does Nanomedicine Have a Delivery Problem?
Torrice, M. (2016) · ACS Central Science · doi:10.1021/acscentsci.6b00190 · Cited by 166
Localized Co-delivery of Doxorubicin, Cisplatin, and Methotrexate by Thermosensitive Hydrogels for Enhanced Osteosarcoma Treatment
Ma, H., He, C., Cheng, Y., Yang, Z., Zang, J., Liu, J., & Chen, X. (2015) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.5b09112 · Cited by 154
Polysaccharide and polypeptide based injectable thermo-sensitive hydrogels for local biomedical applications.
Darge, H. F., Andrgie, A., Tsai, H.-C., & Lai, J. (2019) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2019.04.131 · Cited by 143
Self-citation
Injectable Hydrogel–Microsphere Construct with Sequential Degradation for Locally Synergistic Chemotherapy
Zheng, Y., Cheng, Y., Chen, J., Ding, J., Li, M., Li, C., Wang, J., & Chen, X. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b15245 · Cited by 119
Combined-therapeutic strategies synergistically potentiate glioblastoma multiforme treatment via nanotechnology
Yang, J., Shi, Z., Liu, R., Wu, Y., & Zhang, X. (2020) · Theranostics · doi:10.7150/thno.40298 · Cited by 109
Redox and pH Dual-Responsive Polymeric Micelles with Aggregation-Induced Emission Feature for Cellular Imaging and Chemotherapy
Zhuang, W., Xu, Y., Li, G., Hu, J. X., Ma, B., Yu, T., Su, X., & Wang, Y. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b02890 · Cited by 106
Thermogelling Polymer–Platinum(IV) Conjugates for Long-Term Delivery of Cisplatin
Shen, W., Luan, J., Cao, L., Sun, J., Yu, L., & Ding, J. (2014) · Biomacromolecules · doi:10.1021/bm501220a · Cited by 103
In situ gelling and mucoadhesive polymers: why do they need each other?
Zahir‐Jouzdani, F., Wolf, J. D., Atyabi, F., et al. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1517741 · Cited by 103
A high therapeutic efficacy of polymeric prodrug nano-assembly for a combination of photodynamic therapy and chemotherapy
Yi, X., Dai, J., Han, Y., Xu, M., Zhang, X., Zhen, S., Zhao, Z., Lou, X., & Xia, F. (2018) · Communications Biology · doi:10.1038/s42003-018-0204-6 · Cited by 97
The anti-angiogenic effect and novel mechanisms of action of Combretastatin A-4
Su, M., Huang, J., Liu, S., Xiao, Y., Qin, X., Liu, J., Pi, C., Luo, T., Li, J., Chen, X., et al. (2016) · Scientific Reports · doi:10.1038/srep28139 · Cited by 86
Stimuli-Responsive InjectableIn situ-Forming Hydrogels for Regenerative Medicines
Kim, D. Y., Kwon, D. Y., Kwon, J. S., Kim, J. H., Min, B. H., & Kim, M. S. (2015) · Journal of macromolecular science. Part C, Reviews in macromolecular chemistry and physics/Journal of macromolecular science. Reviews in macromolecular chemistry and physics · doi:10.1080/15583724.2014.983244 · Cited by 78
PEG based anti-cancer drug conjugated prodrug micelles for the delivery of anti-cancer agents
Senevirathne, S. A., Washington, K. E., Biewer, M. C., & Stefan, M. C. (2015) · Journal of Materials Chemistry B · doi:10.1039/c5tb02053k · Cited by 76
Preparation of in situ hydrogels loaded with azelaic acid nanocrystals and their dermal application performance study
Tomić, I., Juretić, M., Jug, M., et al. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.04.016 · Cited by 73
Localized controlled release of bevacizumab and doxorubicin by thermo-sensitive hydrogel for normalization of tumor vasculature and to enhance the efficacy of chemotherapy
Darge, H. F., Andrgie, A. T., Hanurry, E. Y., Birhan, Y. S., Mekonnen, T. W., Chou, H., Hsu, W., Lai, J., Lin, S., & Tsai, H.-C. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118799 · Cited by 67
Self-citation
Selective Cytotoxicity to HER2 Positive Breast Cancer Cells by Saporin-Loaded Nanobody-Targeted Polymeric Nanoparticles in Combination with Photochemical Internalization
Martínez-Jothar, L., Beztsinna, N., van Nostrum, C. F., Hennink, W. E., & Oliveira, S. (2019) · Molecular Pharmaceutics · doi:10.1021/acs.molpharmaceut.8b01318 · Cited by 66
Vascular-disrupting agents in oncology
Mita, M. M., Sargsyan, L., Mita, A. C., et al. (2013) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2013.759557 · Cited by 65
Redox-Responsive Biomimetic Polymeric Micelle for Simultaneous Anticancer Drug Delivery and Aggregation-Induced Emission Active Imaging
Hu, J. X., Zhuang, W., Ma, B., Su, X., Yu, T., Li, G., Hu, Y., & Wang, Y. (2018) · Bioconjugate Chemistry · doi:10.1021/acs.bioconjchem.8b00119 · Cited by 65
Cisplatin Cross-Linked Multifunctional Nanodrugplexes for Combination Therapy
Zhang, W., & Tung, C. (2017) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.6b16500 · Cited by 64
Injectable Hydrogels Coencapsulating Granulocyte-Macrophage Colony-Stimulating Factor and Ovalbumin Nanoparticles to Enhance Antigen Uptake Efficiency
Sun, Z., Liang, J., Dong, X., et al. (2018) · ACS Applied Materials & Interfaces · doi:10.1021/acsami.8b04312 · Cited by 62
PEG-Derivatized Dual-Functional Nanomicelles for Improved Cancer Therapy
Li, Y., Zhang, T., Liu, Q., & He, J. (2019) · Frontiers in Pharmacology · doi:10.3389/fphar.2019.00808 · Cited by 59
Thermoresponsive physical hydrogels of poly(lactic acid)/poly(ethylene glycol) stereoblock copolymers tuned by stereostructure and hydrophobic block sequence
Mao, H., Shan, G., Bao, Y., Wu, Z. L., & Pan, P. (2016) · Soft Matter · doi:10.1039/c6sm00517a · Cited by 58
Development of a dual drug-loaded hydrogel delivery system for enhanced cancer therapy: in situ formation, degradation and synergistic antitumor efficiency
Cheng, C., Zhang, X., Meng, Y., et al. (2017) · Journal of Materials Chemistry B · doi:10.1039/c7tb02173a · Cited by 57
Synthesis, characterization and drug loading property of Monomethoxy-Poly(ethylene glycol)-Poly(ε-caprolactone)-Poly(D,L-lactide) (MPEG-PCLA) copolymers
Chu, B., Zhang, L., Qu, Y., Chen, X., Peng, J., Huang, Y., & Qian, Z. (2016) · Scientific Reports · doi:10.1038/srep34069 · Cited by 55
Transferrin-Modified Nanoparticles for Photodynamic Therapy Enhance the Antitumor Efficacy of Hypocrellin A
Lin, X., Yan, S., Qi, S., Xu, Q., Han, S., Guo, L.-Y., Zhao, N., Chen, S., & Yu, S. (2017) · Frontiers in Pharmacology · doi:10.3389/fphar.2017.00815 · Cited by 53
Fabrication of redox-responsive Bi(mPEG-PLGA)-Se2 micelles for doxorubicin delivery
Birhan, Y. S., Hailemeskel, B. Z., Mekonnen, T. W., Hanurry, E. Y., Darge, H. F., Andrgie, A. T., Chou, H., Lai, J., Hsiue, G., & Tsai, H. (2019) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2019.118486 · Cited by 49
Self-citation
Temporal aspects of the action of ASA404 (vadimezan; DMXAA)
Baguley, B. C., & Siemann, D. W. (2010) · Expert Opinion on Investigational Drugs · doi:10.1517/13543784.2010.529128 · Cited by 47
Inhibiting Solid Tumor Growth In Vivo by Non‐Tumor‐Penetrating Nanomedicine
Lv, S., Tang, Z., Song, W., Zhang, D., Li, M., Liu, H., Cheng, J., Zhong, W., & Chen, X. (2017) · Small · doi:10.1002/smll.201600954 · Cited by 47
Combination of anti-vascular agent - DMXAA and HIF-1α inhibitor - digoxin inhibits the growth of melanoma tumors
Smolarczyk, R., Cichoń, T., Pilny, E., Jarosz–Biej, M., Poczkaj, A., Kułach, N., & Szala, S. (2018) · Scientific Reports · doi:10.1038/s41598-018-25688-y · Cited by 46
Surgery-free injectable macroscale biomaterials for local cancer immunotherapy
Lei, K., & Tang, L. (2018) · Biomaterials Science · doi:10.1039/c8bm01470a · Cited by 46
The effect of PLGA-based hydrogel scaffold for improving the drug maximum-tolerated dose for in situ osteosarcoma treatment
Yang, Z., Yu, S., Li, D., Gong, Y., Zang, J., Liu, J., & Chen, X. (2018) · Colloids and Surfaces B Biointerfaces · doi:10.1016/j.colsurfb.2018.08.048 · Cited by 44
Design, synthesis, and biological evaluation of C7-functionalized DMXAA derivatives as potential human-STING agonists
Hwang, J., Kang, T., Lee, J. H., Choi, B., & Han, S. (2018) · Organic & Biomolecular Chemistry · doi:10.1039/c8ob01798k · Cited by 39
In vitro uptake and transport studies of PEG-PLGA polymeric micelles in respiratory epithelial cells
Hu, X., Yang, F., Liu, C., Ehrhardt, C., & Liao, Y. (2017) · European Journal of Pharmaceutics and Biopharmaceutics · doi:10.1016/j.ejpb.2017.01.004 · Cited by 35
Redox-Responsive Heparin–Chlorambucil Conjugate Polymeric Prodrug for Improved Anti-Tumor Activity
Andrgie, A. T., Birhan, Y. S., Mekonnen, T. W., et al. (2019) · Polymers · doi:10.3390/polym12010043 · Cited by 35
Selenium-containing thermogel for controlled drug delivery by coordination competition
Luan, J., Shen, W., Chen, C., et al. (2015) · RSC Advances · doi:10.1039/c5ra22307e · Cited by 30
Non‐Anticoagulant Heparin Prodrug Loaded Biodegradable and Injectable Thermoresponsive Hydrogels for Enhanced Anti‐Metastasis Therapy
Andrgie, A. T., Mekuria, S. L., Addisu, K. D., Hailemeskel, B. Z., Hsu, W., Tsai, H., & Lai, J. (2019) · Macromolecular Bioscience · doi:10.1002/mabi.201800409 · Cited by 28
Self-citation
Carboxylated poly(glycerol methacrylate)s for doxorubicin delivery
Ma, Y., Gao, H., Gu, W., et al. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.10.025 · Cited by 27
A self-healable fluorescence active hydrogel based on ionic block copolymers prepared via ring opening polymerization and xanthate mediated RAFT polymerization
Banerjee, S. L., Hoskins, R., Swift, T., Rimmer, S., & Singha, N. K. (2018) · Polymer Chemistry · doi:10.1039/c7py01883e · Cited by 27
Tumor Neovasculature-Targeted APRPG-PEG-PDLLA/MPEG-PDLLA Mixed Micelle Loading Combretastatin A-4 for Breast Cancer Therapy
Hao, Y., Peng, J., Zhang, Y., Chen, L., Luo, F., Wang, C., & Qian, Z. (2017) · ACS Biomaterials Science & Engineering · doi:10.1021/acsbiomaterials.7b00523 · Cited by 26
TNF alpha signaling is associated with therapeutic responsiveness to vascular disrupting agents in endocrine tumors
Hantel, C., Ozimek, A., Lira, R. C. P., Ragazzon, B., Jäckel, C., Frantsev, R. S., Reincke, M., Bertherat, J. Y., Mussack, T., & Beuschlein, F. (2016) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2015.12.009 · Cited by 19
Thermosensitive polymeric micelles based on the triblock copolymer poly( d,l ‐lactide)‐b‐poly(N‐isopropyl acrylamide)‐b‐poly( d,l ‐lactide) for controllable drug delivery
Li, P., Zhang, Z., Su, Z., & Wei, G. (2017) · Journal of Applied Polymer Science · doi:10.1002/app.45304 · Cited by 17
The expanding regulatory network of STING-mediated signaling
Surpris, G., & Poltorak, A. (2016) · Current Opinion in Microbiology · doi:10.1016/j.mib.2016.05.014 · Cited by 14
Blends of Oppositely Charged PEG–PPG–PEG Copolymers Displaying Improved Physical Thermogelling Properties
Lee, S. Y., Lee, Y., Chae, S. Y., Park, T. G., & Ahn, C. (2010) · Macromolecular Chemistry and Physics · doi:10.1002/macp.200900498 · Cited by 10
Carboxylic Terminated Thermo-Responsive Copolymer Hydrogel and Improvement in Peptide Release Profile
Rao, Z.-K., Chen, R., Zhu, H., et al. (2018) · Materials · doi:10.3390/ma11030338 · Cited by 10
Synthesis of a biodegradable branched copolymer mPEG-b-PLGA-g-OCol and its pH-sensitive micelle
Li, Y., Zhang, X., Zhang, J., Ma, J., Chi, L., Qiu, N., & Li, Y. (2019) · Materials Science and Engineering C · doi:10.1016/j.msec.2019.110455 · Cited by 8
Cytotoxicity of hyaluronic acid coated chitosan nanoparticles containing nitric oxide donor against cancer cell lines
Pelegrino, M. T., Baldi, C., de Souza, A. C. S., et al. (2019) · Journal of Physics Conference Series · doi:10.1088/1742-6596/1323/1/012019 · Cited by 7

Flagged first, then by citations

Research works printed but not linked: 3

Mita, 2013, Vascular-disrupting agents in oncology, Expert Opin. Invest. Drugs, 22, 317, 10.1517/13543784.2013.759557 · DOI
A. Poltorak, O. Kurmyshkina, T. Volkova, Stimulator of interferon genes (STING): a “new chapter” in virus-associated cancer research. Lessons from wild-derived mouse models of innate immunity, Cytokine Growth Factor Rev. 29 (2016) 83-91. · DOI
A.J.T. Stefan Wilhelm, Qin Dai, Seiichi Ohta, Julie Audet, Harold F. Dvorak and Warren C. W. Chan, Analysis of nanoparticle delivery to tumours, Nat. Rev. Mater. 1 (2016) 1–12. · DOI · Paper page

Sorted by citations

Recent Advances in Nanomicelles Delivery Systems.
Tawfik, S. M., Azizov, S., Elmasry, M. R., Sharipov, M., & Lee, Y.-I. (2020) · Nanomaterials · doi:10.3390/nano11010070 · Cited by 156
“[177] developed DOX-mPPD micelles based on temperature-sensitive copolymers with good loading capacity, 6.”
An injectable thermosensitive hydrogel for dual delivery of diclofenac and avastin® to effectively suppress inflammatory corneal neovascularization
Shi, H., Zhu, Y., Xing, C., Li, S., Bao, Z., Lei, L., Lin, D., Wang, Y., Chen, H., & Xu, X. (2022) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2022.122081 · Cited by 29

See all 81

Authors: Fentahun Darge, H., Yibru Hanurry, E., Simegniew Birhan, Y., Worku Mekonnen, T., Tizazu Andrgie, A., Chou, H.-Y., Lai, J.-Y., & Tsai, H.-C.
Affiliations: National Taiwan University of Science and Technology (TW)
Chung Yuan Christian University (TW)
Corresponding author: Tsai, Hsieh-Chih
ORCID: Lai, Juin-Yih
Tsai, Hsieh-Chih
Venue: Chemical Engineering Journal
Publisher: Elsevier BV
Published: 2021-02
Volume: 406
Pages: 126879
ISSN: 1385-8947 (ISSN-L)
DOI: 10.1016/j.cej.2020.126879
OpenAlex: W3083472810
Cited by: 81
References: 56
Citations by year: 2026: 3 · 2025: 10 · 2024: 16 · 2023: 19 · 2022: 20 · 2021: 10
FWCI: 4.33
Type: journal article
Language: en
Open access: closed
Licence: www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
Locations: Chemical Engineering Journal (publishedVersion)
Funders: Ministry of Science and Technology, Taiwan (MOST105-2221-E-011-133-MY3, 105-2221-E-011-151-MY3)
Topics: Physical Sciences › Materials Science › Biomaterials › Hydrogels: synthesis, properties, applications
Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
Keywords: drug-loaded micelles, thermosensitive hydrogel, localized cancer therapy, doxorubicin, DMXAA, sequential drug release, anti-angiogenic therapy, immunotherapy, combination chemotherapy, intratumoral injection, tumor microvessel density, TNF-α, interferon-beta, sustained drug release, biocompatibility

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Multifunctional drug-loaded micelles encapsulated in thermo-sensitive hydrogel for in vivo local cancer treatment: Synergistic effects of anti-vascular and immuno-chemotherapy

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cites

Cited by

Related

Metadata

Record

About these checks