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Cited by 266Research on Leishmaniasis StudiesGalectins and Cancer BiologyInvertebrate Immune Response Mechanisms

The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.

A Role for Insect Galectins in Parasite Survival

Open access
Kamhawi, Shaden, Ramalho-Ortigao, Marcelo, Van M. Pham, Kumar, Sanjeev, Lawyer, Phillip G., Turco, Salvatore J., Barillas-Mury, Carolina, Sacks, David L., Valenzuela, Jesus G.·2004·Cell
DOI 10.1016/j.cell.2004.10.009
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Abstract

Insect galectins are associated with embryonic development or immunity against pathogens. Here, we show that they can be exploited by parasites for survival in their insect hosts. PpGalec, a tandem repeat galectin expressed in the midgut of the sandfly Phlebotomus papatasi, is used by Leishmania major as a receptor for mediating specific binding to the insect midgut, an event crucial for parasite survival, and accounts for species-specific vector competence for the most widely distributed form of cutaneous leishmaniasis in the Old World. In addition, these studies demonstrate the feasibility of using midgut receptors for parasite ligands as target antigens for transmission-blocking vaccines.

Overview

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Registry

Crossref · 10.1016/j.cell.2004.10.009

Cites

54 of 54 references verified0 citation errors · 0 not checkable

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  • Lipophosphoglycan of Leishmania species is needed for establishment of initial infections in vertebrate hosts, and not for persistence or pathology, but is later needed for binding to galectins located on the surface of midguts of their invertebrate vectors.

    “An example is the lipophosphoglycan of Leishmania species, which is needed for establishment of initial infections in vertebrate hosts, and not for persistence or pathology (1006) --but is later needed for binding to galectins located on the surface of midguts of their invertebrate vectors (1007).”

    From Biological roles of glycans (2017) · cites this paper as [1007]

Citations

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Research works printed but not linked: 2

  1. Page, 1996, TreeView, Comput. Appl. Biosci, 12, 357
  2. Wallbanks, 1986, The agglutination of erythrocytes and Leishmania parasites by sand fly gut extracts, Trop. Med. Parasitol, 37, 409

Cited by

Sorted by citations

  • Biological roles of glycans

    Varki, A. (2017) · Glycobiology · doi:10.1093/glycob/cww086 · Cited by 2,635

    “An example is the lipophosphoglycan of Leishmania species, which is needed for establishment of initial infections in vertebrate hosts, and not for persistence or pathology (1006)––but is later needed for binding to galectins located on the surface of midguts of their invertebrate vectors (1007).”
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Related

Metadata

Authors
Kamhawi, S., Ramalho-Ortigao, M., Pham, V. M., Kumar, S., Lawyer, P. G., Turco, S. J., Barillas-Mury, C., Sacks, D. L., & Valenzuela, J. G.
Affiliations
  • National Institutes of Health (US)
  • University of Kentucky (US)
Corresponding author
Valenzuela, Jesus G.
ORCID
Venue
Cell
Publisher
Elsevier BV
Published
2004-10
Volume
119
Issue
3
Pages
329-341
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2004.10.009
OpenAlex
W2113928427
Cited by
266
References
54
Citations by year
2026: 2 · 2025: 11 · 2024: 9 · 2023: 8 · 2022: 15 · 2021: 12 · 2020: 18 · 2019: 11 · 2018: 16 · 2017: 11 · 2016: 17 · 2015: 16 · 2014: 9 · 2013: 13 · 2012: 14
FWCI
12.90
Type
journal article
Language
en
Open access
Licence
Locations
  • Cell (publishedVersion)
  • PubMed (publishedVersion)
Funders
National Institute of Allergy and Infectious Diseases (AI20941)
Topics
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Research on Leishmaniasis Studies
  • Life Sciences › Immunology and Microbiology › Immunology › Galectins and Cancer Biology
  • Life Sciences › Immunology and Microbiology › Immunology › Invertebrate Immune Response Mechanisms
Keywords
tandem-repeat galectins, Phlebotomus papatasi, Leishmania major, cutaneous leishmaniasis, transmission-blocking vaccine, host-parasite interactions
MeSH terms
Amino Acid Sequence, Animals, Cell Adhesion, Glycosphingolipids, Host-Parasite Interactions, Insect Vectors, Leishmania, Leishmaniasis, Molecular Sequence Data, Psychodidae, Species Specificity, Galectins, Gastrointestinal Tract

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