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Identification of Intrinsic Determinants of Midbrain Dopamine Neurons
Open accessAbstract
The prospect of using cell replacement therapies has raised the key issue of whether elucidation of developmental pathways can facilitate the generation of therapeutically important cell types from stem cells. Here we show that the homeodomain proteins Lmx1a and Msx1 function as determinants of midbrain dopamine neurons, cells that degenerate in patients with Parkinson's disease. Lmx1a is sufficient and required to trigger dopamine cell differentiation. An early activity of Lmx1a is to induce the expression of Msx1, which complements Lmx1a by inducing the proneural protein Ngn2 and neuronal differentiation. Importantly, expression of Lmx1a in embryonic stem cells results in a robust generation of dopamine neurons with a "correct" midbrain identity. These data establish that Lmx1a and Msx1 are critical intrinsic dopamine-neuron determinants in vivo and suggest that they may be essential tools in cell replacement strategies in Parkinson's disease.
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“The caudal extent is defined by the Otx2/Gbx2 boundary coincident with the morphological mid-hindbrain boundary [74]. The rostral extent is defined by the En1/Dbx1 gene expression boundary which is located in the diencephalic region [75–78]. The dorsal extent is defined by the Lmx1a/Nkx6.1 gene expression boundary [71,79–81].”
From Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches (2020) · cites this paper as [71]
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“These neurons originate from the mesodiencephalic floorplate (FP), a region at the ventral midline defined by the mRNA expression of Shh+ and Foxa2+ [67–73].”
From Classification of midbrain dopamine neurons using single-cell gene expression profiling approaches (2020) · cites this paper as [71]
Citations
Cites
Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Jessell, T. M. (2000) · Nature Reviews Genetics · doi:10.1038/35049541 · Cited by 2,089
Directed differentiation of embryonic stem cells into motor neurons.
Wichterle, H., Lieberam, I., Porter, J. A., & Jessell, T. (2002) · Cell · doi:10.1016/s0092-8674(02)00835-8 · Cited by 1,792
Proneural genes and the specification of neural cell types
Bertrand, N., Castro, D. S., & Guillemot, F. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn874 · Cited by 1,572
Conversion of embryonic stem cells into neuroectodermal precursors in adherent monoculture
Ying, Q.-L., Stavridis, M., Griffiths, D., Li, M., & Smith, A. (2003) · Nature Biotechnology · doi:10.1038/nbt780 · Cited by 1,504
Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells
Lee, S., Lumelsky, N. L., Studer, L., Auerbach, J. M., & McKay, R. D. G. (2000) · Nature Biotechnology · doi:10.1038/76536 · Cited by 1,261
In situ hybridization; a practical approach
(1993) · International Journal of Biochemistry · doi:10.1016/0020-711x(93)90093-t · Cited by 1,240
Briscoe, J., Pierani, A., Jessell, T. M., & Ericson, J. (2000) · Cell · doi:10.1016/s0092-8674(00)80853-3 · Cited by 1,111
Self-citationDopamine Neuron Agenesis in Nurr1-Deficient Mice
Zetterström, R. H., Solomin, L., Jansson, L., Hoffer, B. J., Olson, L., & Perlmann, T. (1997) · Science · doi:10.1126/science.276.5310.248 · Cited by 1,096
Self-citationEllis, L., Clauser, E., Morgan, D. O., Edery, M., Roth, R. A., & Rutter, W. J. (1986) · Cell · doi:10.1016/0092-8674(86)90786-5 · Cited by 1,070
The bHLH Transcription Factors OLIG2 and OLIG1 Couple Neuronal and Glial Subtype Specification
Zhou, Q., & Anderson, D. J. (2002) · Cell · doi:10.1016/s0092-8674(02)00677-3 · Cited by 1,059
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- Simon, 1998, En-1 and En-2 control the fate of the dopaminergic neurons in the substantia nigra and ventral tegmentum, Eur. J. Neurosci., 10, 389
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Sorted by citations
Items 201–300 of 587
Stem Cells asIn VitroModel of Parkinson's Disease
Martínez‐Morales, P., & Liste, I. (2012) · Stem Cells International · doi:10.1155/2012/980941 · Cited by 42
Cave, J. W., Wang, M., & Baker, H. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00016 · Cited by 43
Freed, W. J., Jia, C., Bäckman, C. M., Schwartz, C. M., Vazin, T., Cai, J., Spivak, C. E., Lupica, C. R., Rao, M. S., & Zeng, X. (2008) · PLoS ONE · doi:10.1371/journal.pone.0001422 · Cited by 40
Foxa1 and Foxa2 Transcription Factors Regulate Differentiation of Midbrain Dopaminergic Neurons
Ang, S. (2009) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-0322-8_5 · Cited by 40
Uhde, C. W., Vives, J., Jaeger, I. S., & Li, M. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008641 · Cited by 41
In Vitro Generation of Dopaminergic Neurons from Adult Subventricular Zone Neural Progenitor Cells
Papanikolaou, T., Lennington, J. B., Betz, A. J., Figueiredo, C., Salamone, J. D., & Conover, J. C. (2008) · Stem Cells and Development · doi:10.1089/scd.2007.0090 · Cited by 41
Stock, K., Nolden, L., Edenhofer, F., Quandel, T., & Brüstle, O. (2010) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-010-0347-1 · Cited by 42
Krasnova, I. N., Ladenheim, B., Hodges, A. B., Volkow, N. D., & Cadet, J. L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0019179 · Cited by 40
Ko, J., Lee, H., Park, C., Koh, H.-C., Lee, Y., & Lee, S. (2009) · Molecular Therapy · doi:10.1038/mt.2009.148 · Cited by 40
Efficient generation of dopaminergic induced neuronal cells with midbrain characteristics
Ng, Y. H., Chanda, S., Janas, J. A., Yang, N., Kokubu, Y., Südhof, T. C., & Wernig, M. (2021) · Stem Cell Reports · doi:10.1016/j.stemcr.2021.05.017 · Cited by 40
Human neural organoids: Models for developmental neurobiology and disease
Guy, B., Zhang, J. S., Duncan, L. H., & Johnston, R. J. (2021) · Developmental Biology · doi:10.1016/j.ydbio.2021.06.012 · Cited by 43
Singh, S., Mishra, A., & Shukla, S. (2015) · Molecular Neurobiology · doi:10.1007/s12035-015-9361-5 · Cited by 40
Manifold functions of the Nail‐Patella Syndrome gene Lmx1b in vertebrate development
Dai, J., Johnson, R. L., & Ding, Y. (2009) · Development Growth & Differentiation · doi:10.1111/j.1440-169x.2008.01083.x · Cited by 40
Brown, A., Machan, J. T., Hayes, L. N., & Zervas, M. (2011) · The Journal of Comparative Neurology · doi:10.1002/cne.22710 · Cited by 40
Hoekstra, E. J., von Oerthel, L., van der Heide, L. P., Kouwenhoven, W. M., Veenvliet, J. V., Wever, I., Jin, Y.-R., Yoon, J. K., van der Linden, A. J. A., Holstege, F. C. P., et al. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074049 · Cited by 41
Abdelrahman, S., Alsanie, W. F., Khan, Z. N., Albalawi, H. I., Felimban, R. I., Moretti, M., Steiner, N., Chaudhary, A., & Hauser, C. A. E. (2022) · Biofabrication · doi:10.1088/1758-5090/ac7eec · Cited by 41
A novel role for FOXA2 and SHH in organizing midbrain signaling centers
Bayly, R. D., Brown, C. Y., & Agarwala, S. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.06.018 · Cited by 39
Regulation of the Noradrenaline Neurotransmitter Phenotype by the Transcription Factor AP-2β
Hong, S. J., Lardaro, T., Oh, M. S., Huh, Y., Ding, Y., Kang, U. J., Kirfel, J., Buettner, R., & Kim, K. (2008) · Journal of Biological Chemistry · doi:10.1074/jbc.m709106200 · Cited by 39
Reserve pool neuron transmitter respecification: Novel neuroplasticity
Dulcis, D., & Spitzer, N. C. (2011) · Developmental Neurobiology · doi:10.1002/dneu.20920 · Cited by 39
The Role of Otx2 in Adult Mesencephalic–Diencephalic Dopaminergic Neurons
Simeone, A., Salvio, M. D., Giovannantonio, L. G. D., Acampora, D., Omodei, D., & Tomasetti, C. (2010) · Molecular Neurobiology · doi:10.1007/s12035-010-8148-y · Cited by 38
Fischer, T. H., Faus-Keßler, T., Welzl, G., Simeone, A., Wurst, W., & Prakash, N. (2010) · Developmental Biology · doi:10.1016/j.ydbio.2010.12.017 · Cited by 38
Gennet, N., Gale, E. A., Nan, X., Farley, E. K., Takács, K., Oberwallner, B., Chambers, D. J., & Li, M. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1016679108 · Cited by 38
Current status of treating neurodegenerative disease with induced pluripotent stem cells
Pen, A. E., & Jensen, U. B. (2016) · Acta Neurologica Scandinavica · doi:10.1111/ane.12545 · Cited by 37
Mesman, S., & Smidt, M. P. (2017) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2017.00353 · Cited by 38
Comparative review of adult midbrain and striatum neurogenesis with classical neurogenesis
Farzanehfar, P. (2018) · Neuroscience Research · doi:10.1016/j.neures.2018.01.002 · Cited by 39
Huang, M., Sage, C., Li, H., Xiang, M., Heller, S., & Chen, Z. (2008) · Developmental Dynamics · doi:10.1002/dvdy.21735 · Cited by 38
Cell-Based Therapies for Parkinson's Disease: Past, Present, and Future
Fitzpatrick, K. M., Raschke, J., & Emborg, M. E. (2009) · Antioxidants and Redox Signaling · doi:10.1089/ars.2009.2654 · Cited by 38
Hedlund, E., Belnoue, L., Theofilopoulos, S., Saltó, C., Bye, C. R., Parish, C. L., Deng, Q., Kadkhodaei, B., Ericson, J., Arenas, E., et al. (2016) · Scientific Reports · doi:10.1038/srep26448 · Cited by 37
Self-citationColleoni, S., Galli, C., Giannelli, S. G., Armentero, M., Blandini, F., Broccoli, V., & Lazzari, G. (2010) · Experimental Cell Research · doi:10.1016/j.yexcr.2010.02.013 · Cited by 36
Generation of Integration‐Free Induced Neurons Using Graphene Oxide‐Polyethylenimine
Baek, S., Oh, J., Song, J., Choi, H. G., Yoo, J., Park, G., Han, J., Chang, Y., Park, H., Kim, H., et al. (2016) · Small · doi:10.1002/smll.201601993 · Cited by 36
Acquisition of the Midbrain Dopaminergic Neuronal Identity
Mesman, S., & Smidt, M. P. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21134638 · Cited by 36
Ono, Y., Nakatani, T., Minaki, Y., & Kumai, M. (2010) · Development · doi:10.1242/dev.042572 · Cited by 36
Baizabal, J., & Covarrubias, L. (2008) · Developmental Biology · doi:10.1016/j.ydbio.2008.09.024 · Cited by 38
Lin, M., Mackie, P. M., Shaerzadeh, F., Gamble‐George, J., Miller, D. R., Martyniuk, C. J., & Khoshbouei, H. (2021) · Acta Neuropathologica Communications · doi:10.1186/s40478-021-01203-9 · Cited by 37
Early specification of dopaminergic phenotype during ES cell differentiation
Parmar, M., & Li, M. C. (2007) · BMC Developmental Biology · doi:10.1186/1471-213x-7-86 · Cited by 34
Lahti, L., Peltopuro, P., Piepponen, T. P., & Partanen, J. (2012) · Development · doi:10.1242/dev.071936 · Cited by 34
The Use of Stem Cells in Regenerative Medicine for Parkinson's and Huntington's Diseases
Lescaudron, L., Naveilhan, P., & Neveu, I. (2012) · Current Medicinal Chemistry · doi:10.2174/0929867311209066018 · Cited by 34
Nouri, N., & Awatramani, R. B. (2017) · Development · doi:10.1242/dev.144949 · Cited by 38
Chabrat, A., Brisson, G. J., Doucet-Beaupré, H., Salesse, C., Profes, M. S., Dovonou, A., Akitegetse, C., Charest, J., Lemstra, S., Côté, D. C., et al. (2017) · Nature Communications · doi:10.1038/s41467-017-01042-0 · Cited by 33
de Luzy, I. R., Niclis, J. C., Gantner, C. W., Kauhausen, J. A., Hunt, C. J., Ermine, C. M., Pouton, C. W., Thompson, L. H., & Parish, C. L. (2019) · Journal of Neuroscience · doi:10.1523/jneurosci.1160-19.2019 · Cited by 34
Alekseenko, Z., Dias, J. M. M., Adler, A. F., Kozhevnikova, M. N., van Lunteren, J. A., Nolbrant, S., Jeggari, A., Vasylovska, S., Yoshitake, T., Kehr, J., et al. (2022) · Nature Communications · doi:10.1038/s41467-022-30777-8 · Cited by 38
Self-citationNi, N., Hu, Y., Ren, H., Luo, C., Li, P., Wan, J., & Su, H. (2013) · PLoS ONE · doi:10.1371/journal.pone.0084504 · Cited by 34
Guo, T., Finnis, K. W., Parrent, A. G., & Peters, T. M. (2006) · Computer Aided Surgery · doi:10.1080/10929080600997232 · Cited by 34
Wagenführ, L., Meyer, A. K., Marrone, L., & Storch, A. (2015) · Stem Cells and Development · doi:10.1089/scd.2015.0214 · Cited by 34
Nouri, N., Patel, M. J., Joksimovic, M., Poulin, J.-F., Anderegg, A., Taketo, M. M., Ma, Y. C., & Awatramani, R. B. (2015) · Molecular and Cellular Neuroscience · doi:10.1016/j.mcn.2015.07.002 · Cited by 34
Lmx1a enhances the effect of iNSCs in a PD model
Wu, J., Sheng, C., Liu, Z., Jia, W., Wang, B., Li, M., Fu, L., Ren, Z., An, J., Sang, L., et al. (2014) · Stem Cell Research · doi:10.1016/j.scr.2014.10.004 · Cited by 33
FoxP1 promotes midbrain identity in embryonic stem cell‐derived dopamine neurons by regulating Pitx3
Konstantoulas, C. J., Parmar, M., & Li, M. (2010) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2010.06650.x · Cited by 33
Li, W., Chen, S., & Li, J. (2015) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2015.09.009 · Cited by 35
Du, F., Qing, Y., Yan, S., Chen, D., & Yan, S. S. (2016) · Stem Cell Reports · doi:10.1016/j.stemcr.2016.08.014 · Cited by 35
Brodski, C., Blaess, S., Partanen, J. M., & Prakash, N. (2019) · Journal of Developmental Biology · doi:10.3390/jdb7010003 · Cited by 35
Preclinical Assessment of Stem Cell Therapies for Neurological Diseases
Joers, V. L., & Emborg, M. E. (2010) · ILAR Journal · doi:10.1093/ilar.51.1.24 · Cited by 34
Substantia Nigra, Ventral Tegmental Area, and Retrorubral Fields
Halliday, G. M., Reyes, S., & Double, K. L. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-374236-0.10013-6 · Cited by 34
Correia, A. S. (2007) · Frontiers in Neuroanatomy · doi:10.3389/neuro.05.004.2007 · Cited by 33
Roles for the TGFβ Superfamily in the Development and Survival of Midbrain Dopaminergic Neurons
Hegarty, S. V., Sullivan, A. M., & O’Keeffe, G. W. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8639-3 · Cited by 32
Nishimura, K., Yang, S., Lee, K. W., Ásgrímsdóttir, E. S., Nikouei, K., Pasławski, W., Gnodde, S., Lyu, G., Hu, L., Saltó, C., et al. (2022) · Stem Cell Reports · doi:10.1016/j.stemcr.2022.10.016 · Cited by 33
Derivation of Functional Dopamine Neurons from Embryonic Stem Cells
Kim, D., Kim, J. Y., Kang, M., Cho, M. S., & Kim, D. (2007) · Cell Transplantation · doi:10.3727/000000007783464650 · Cited by 32
Induced dopaminergic neurons: A new promise for Parkinson’s disease
Xu, Z., Chu, X., Jiang, H., Schilling, H. A., Chen, S., & Feng, J. (2017) · Redox Biology · doi:10.1016/j.redox.2017.01.009 · Cited by 31
Ectopic Wnt/Beta–Catenin Signaling Induces Neurogenesis in the Spinal Cord and Hindbrain Floor Plate
Joksimovic, M., Patel, M. J., Taketo, M. M., Johnson, R. L., & Awatramani, R. B. (2012) · PLoS ONE · doi:10.1371/journal.pone.0030266 · Cited by 30
Differentiation of non-mesencephalic neural stem cells towards dopaminergic neurons
Rössler, R., Boddeke, E., & Copray, S. C. V. M. (2010) · Neuroscience · doi:10.1016/j.neuroscience.2010.07.023 · Cited by 30
Hebsgaard, J. B., Nelander, J., Sabelström, H., Jönsson, M. E., Stott, S., & Parmar, M. (2009) · Glia · doi:10.1002/glia.20877 · Cited by 30
Shim, S., Goyal, R., Panoutsopoulos, A. A., Balashova, O. A., Lee, D., & Borodinsky, L. N. (2023) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2220037120 · Cited by 32
Delic, J., & Zimmermann, H. (2010) · Purinergic Signalling · doi:10.1007/s11302-010-9206-7 · Cited by 29
Borodinsky, L. N., & Belgacem, Y. H. (2015) · Journal of Chemical Neuroanatomy · doi:10.1016/j.jchemneu.2015.12.001 · Cited by 29
Han, M., Lee, E.-H., & Koh, S. (2016) · International Neurourology Journal · doi:10.5213/inj.1632776.388 · Cited by 29
Metzakopian, E., Bouhali, K., Alvarez-Saavedra, M., Whitsett, J. A., Picketts, D. J., & Ang, S. (2015) · Development · doi:10.1242/dev.115808 · Cited by 29
Gyllborg, D., Ahmed, M., Toledo, E. M., Theofilopoulos, S., Yang, S., ffrench-Constant, C., & Arenas, E. (2018) · Stem Cell Reports · doi:10.1016/j.stemcr.2018.07.014 · Cited by 28
Directing neuronal cell fate in vitro: Achievements and challenges
Riemens, R. J. M., van den Hove, D., Esteller, M., & Delgado‐Morales, R. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.04.003 · Cited by 27
Fathi, A., Mirzaei, M., Dolatyar, B., Tabar, M. S., Bayat, M., Shahbazi, E., Lee, J., Javan, M., Zhang, S., Gupta, V., et al. (2018) · Molecular & Cellular Proteomics · doi:10.1074/mcp.ra118.000809 · Cited by 29
Mong, J. C. Y., Panman, L., Alekseenko, Z., Kee, N., Stanton, L. W., Ericson, J., & Perlmann, T. (2013) · Stem Cells · doi:10.1002/stem.1585 · Cited by 28
Self-citationStem cells and the treatment of Parkinson's disease
Ali, F. R., Stott, S., & Barker, R. A. (2013) · Experimental Neurology · doi:10.1016/j.expneurol.2012.12.017 · Cited by 29
Role of Nurr1 in the Generation and Differentiation of Dopaminergic Neurons from Stem Cells
Rodríguez‐Traver, E., Solís, Ó., Díaz‐Guerra, E., Ortiz, Ó., Vergaño‐Vera, E., Méndez‐Gómez, H. R., García‐Sanz, P., Moratalla, R., & Vicario‐Abejón, C. (2015) · Neurotoxicity Research · doi:10.1007/s12640-015-9586-0 · Cited by 28
Otx2 Requires Lmx1b to Control the Development of Mesodiencephalic Dopaminergic Neurons
Sherf, O., Zolotov, L. N., Liser, K., Tilleman, H. G., Jovanovic, V. M., Zega, K., Jukić, M. M., & Brodski, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0139697 · Cited by 28
Volpicelli, F., Perrone‐Capano, C., Bellenchi, G. C., Colucci-D’Amato, L., & di Porzio, U. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21113995 · Cited by 31
Vergaño‐Vera, E., Díaz‐Guerra, E., Rodríguez‐Traver, E., Méndez‐Gómez, H. R., Solís, Ó., Pignatelli, J., Pickel, J. M., Lee, S., Moratalla, R., & Vicario‐Abejón, C. (2014) · Developmental Neurobiology · doi:10.1002/dneu.22251 · Cited by 27
Bergman, O., Westberg, L., Nilsson, L., Adolfsson, R., & Eriksson, E. (2010) · Progress in Neuro-psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.05.032 · Cited by 30
Engrailed signaling in axon guidance and neuron survival
Fuchs, J., Stettler, O., Alvarez‐Fischer, D., Prochiantz, A., Moya, K. L., & Joshi, R. L. (2012) · European Journal of Neuroscience · doi:10.1111/j.1460-9568.2012.08139.x · Cited by 32
Nefzger, C. M., Su, C. T. E., Fabb, S. A., Hartley, B. J., Beh, S. J., Zeng, W. R., Haynes, J. M., & Pouton, C. W. (2012) · Stem Cells · doi:10.1002/stem.1105 · Cited by 27
Anand, A. A. P., Sankar, S. G., & Vani, V. K. (2012) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2012.01607.x · Cited by 27
Duration of Shh signaling contributes to mDA neuron diversity
Hayes, L. N., Ralls, S., Wang, H., & Ahn, S. (2012) · Developmental Biology · doi:10.1016/j.ydbio.2012.11.016 · Cited by 26
Understanding Parkinson’s Disease through the Use of Cell Reprogramming
Playne, R., & Connor, B. J. (2017) · Stem Cell Reviews and Reports · doi:10.1007/s12015-017-9717-5 · Cited by 28
Interspecies Organogenesis for Human Transplantation
Crane, A. T., Aravalli, R. N., Asakura, A., Grande, A. W., Krishna, V. D., Carlson, D. F., Cheeran, M. C. ‐., Danczyk, G., Dutton, J. R., Hackett, P. B., et al. (2019) · Cell Transplantation · doi:10.1177/0963689719845351 · Cited by 26
miR-7 Controls the Dopaminergic/Oligodendroglial Fate through Wnt/β-catenin Signaling Regulation
Adusumilli, L., Facchinello, N., Teh, C., Busolin, G., Le, M. T. N., Yang, H. H., Beffagna, G., Campanaro, S., Tam, W. L., Argenton, F., et al. (2020) · Cells · doi:10.3390/cells9030711 · Cited by 26
Expression of the LIM-homeodomain gene Lmx1a in the postnatal mouse central nervous system
Zou, H.-L., Su, C., Shi, M., Zhao, G., Li, Z., Guo, C., & Ding, Y. (2008) · Brain Research Bulletin · doi:10.1016/j.brainresbull.2008.12.001 · Cited by 26
Giovannantonio, L. G. D., Salvio, M. D., Omodei, D., Prakash, N., Wurst, W., Pierani, A., Acampora, D., & Simeone, A. (2013) · Development · doi:10.1242/dev.102954 · Cited by 26
Tripathi, P. P., & Bozzi, Y. (2015) · Bioimpacts · doi:10.15171/bi.2015.07 · Cited by 26
Allodi, I., & Hedlund, E. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00109 · Cited by 31
Cell reprogramming: Therapeutic potential and the promise of rejuvenation for the aging brain
López-León, M., Outeiro, T. F., & Goya, R. G. (2017) · Ageing Research Reviews · doi:10.1016/j.arr.2017.09.002 · Cited by 27
Chalazonitis, A., Rao, M., & Sulzer, D. (2022) · npj Parkinson s Disease · doi:10.1038/s41531-022-00308-9 · Cited by 27
Denham, M., Thompson, L. H., Leung, J., Pébay, A., Björklund, A., & Dottori, M. (2010) · Stem Cells · doi:10.1002/stem.510 · Cited by 25
BMP‐induced L‐Maf regulates subsequent BMP‐independent differentiation of primary lens fibre cells
Pandit, T., Jidigam, V. K., & Gunhaga, L. (2011) · Developmental Dynamics · doi:10.1002/dvdy.22692 · Cited by 25
Dkk1 Regulates Ventral Midbrain Dopaminergic Differentiation and Morphogenesis
Ribeiro, D., Ellwanger, K., Glagow, D., Theofilopoulos, S., Corsini, N. S., Martín-Villalba, A., Niehrs, C., & Arenas, E. (2011) · PLoS ONE · doi:10.1371/journal.pone.0015786 · Cited by 25
Spatial and Temporal Lineage Analysis of a Pitx3-Driven Cre-Recombinase Knock-In Mouse Model
Smidt, M. P., von Oerthel, L., Hoekstra, E. J., Schellevis, R. D., & Hoekman, M. F. M. (2012) · PLoS ONE · doi:10.1371/journal.pone.0042641 · Cited by 25
Rhim, J. H., Luo, X., Xu, X., Gao, D., Zhou, T., Li, F., Qin, L., Wang, P., Xia, X., & Wong, S. T. C. (2015) · Scientific Reports · doi:10.1038/srep16237 · Cited by 25
Merging Fields: Stem Cells in Neurogenesis, Transplantation, and Disease Modeling
Scheffler, B., Edenhofer, F., & Brüstle, O. (2006) · Brain Pathology · doi:10.1111/j.1750-3639.2006.00010.x · Cited by 25
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Metadata
- Authors
- Andersson, E., Tryggvason, U., Deng, Q., Friling, S., Alekseenko, Z., Robert, B., Perlmann, T., & Ericson, J.
- Affiliations
- Karolinska Institutet (SE)
- Ludwig Cancer Research (SE)
- Corresponding author
- Perlmann, Thomas
- Ericson, Johan
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2006-01
- Volume
- 124
- Issue
- 2
- Pages
- 393-405
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2111525324
- Cited by
- 587
- References
- 59
- Citations by year
- 2026: 14 · 2025: 11 · 2024: 12 · 2023: 15 · 2022: 14 · 2021: 18 · 2020: 22 · 2019: 18 · 2018: 19 · 2017: 21 · 2016: 26 · 2015: 29 · 2014: 22 · 2013: 45 · 2012: 48
- FWCI
- 22.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Pluripotent Stem Cells Research
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Keywords
- midbrain dopaminergic neurons, Lmx1a, MSX1, Ngn2, homeodomain transcription factor, neuronal differentiation, Parkinson's disease, cell replacement therapy, embryonic stem cells, proneural genes
- MeSH terms
- Animals, Cells, Cultured, Chick Embryo, Dopamine, Mesencephalon, Neurons, Stem Cells, Transcription Factors, Signal Transduction, Trans-Activators, Homeodomain Proteins, Embryo Research, Mice, MSX1 Transcription Factor, Hedgehog Proteins, LIM-Homeodomain Proteins
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