Neuronal specification in the spinal cord: inductive signals and transcriptional codes
Abstract
Neural circuits are assembled with remarkable precision during embryonic development, and the selectivity inherent in their formation helps to define the behavioural repertoire of the mature organism. In the vertebrate central nervous system, this developmental program begins with the differentiation of distinct classes of neurons from progenitor cells located at defined positions within the neural tube. The mechanisms that specify the identity of neural cells have been examined in many regions of the nervous system and reveal a high degree of conservation in the specification of cell fate by key signalling molecules.
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The MGE can be subdivided into dorsal, intermediate, and ventrocaudal domains, although subpallial progenitor pools do not segregate as sharply as in the spinal cord.
“the MGE can be further subdivided into dorsal, intermediate and ventrocaudal domains”
From Development and Functional Diversification of Cortical Interneurons (2018) · cites this paper as Jessell, 2000
Driven by transcription factor networks, each type of neural progenitor generates a series of neuronal cell types.
“Second, driven by the transcription factor network, each type of neural progenitors generates a series of neuronal cell types.”
From What is a cell type and how to define it? (2022) · cites this paper as Jessell, 2000
Extensive historical studies of mouse cortex and spinal cord cell types have uncovered several common principles.
“The generation and patterning of mouse cortex and spinal cord cell types are two example systems where extensive historical studies have uncovered several common principles (Cadwell et al., 2019; Catela et al., 2015; Jessell, 2000; O’Leary et al., 2007; Osseward and Pfaff, 2019; Sagner and Briscoe, 2019).”
From What is a cell type and how to define it? (2022) · cites this paper as Jessell, 2000
The set of cell type-defining transcription factors in a progenitor or daughter cell can change with time, so different neuronal types emanate from the same progenitor in a precisely timed birth order.
“The set of cell type-defining transcription factors in a progenitor or a daughter cell can change with time, such that different neuronal types emanate from the same progenitor in a precisely timed “birth order”.”
From What is a cell type and how to define it? (2022) · cites this paper as Jessell, 2000
Specific sets of cell adhesion molecules provide guidance cues for axon path finding and synapse formation, leading to assembly of region- and cell type-specific local and global circuit networks.
“Third, specific sets of cell adhesion molecules provide guidance cues for axon path finding and synapse formation, leading to the assembly of region- and cell type-specific local and global circuit networks.”
From What is a cell type and how to define it? (2022) · cites this paper as Jessell, 2000
Later in development, the same neural progenitors also generate non-neuronal cell types such as astrocytes and oligodendrocytes.
“Later in development, the same neural progenitors also generate non-neuronal cell types such as astrocytes and oligodendrocytes.”
From What is a cell type and how to define it? (2022) · cites this paper as Jessell, 2000
Opposing morphogen gradients establish the basic plan for cortex (anterior-posterior) or spinal cord (dorsal-ventral) patterning and provide instructive signals for expression of complementary transcription factor activators and repressors, which define distinct neural progenitor domains.
“First, opposing morphogen gradients establish the basic plan for cortex (anterior-posterior) or spinal cord (dorsal-ventral) patterning and provide instructive signals for the expression of complementary sets of transcription factor activators and repressors, which in turn define distinct neural progenitor domains within cortex or spinal cord.”
From What is a cell type and how to define it? (2022) · cites this paper as Jessell, 2000
Specification of progenitor domains in the hindbrain and spinal cord relies on WNT and retinoic acid along the rostro-caudal axis and sonic hedgehog along the dorso-ventral axis.
“Specification of the progenitor domains in the hindbrain and spinal cord relies on signaling molecules like WNT and retinoic acid (RA) secreted along the rostro-caudal axis, and sonic hedgehog (SHH) along the dorso-ventral axis”
From Generation of Functional Human 3D Cortico-Motor Assembloids (2020) · cites this paper as Jessell, 2000
The gene expression programme of each progenitor domain determines the neuronal cell type it generates.
“The gene expression programme of each progenitor domain determines the neuronal cell type it generates”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Jessell, 2000
Signals from the dorsal and ventral poles of the neural tube partition progenitors into 13 transcriptionally distinct domains ordered along the dorsal-ventral axis.
“This is directed by signals that emanate from the dorsal and ventral poles of the neural tube that partition progenitors into 13 transcriptionally distinct domains that are ordered along the dorsal ventral axis”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Jessell, 2000
After their generation, MNs diversify and organise into distinct columns and pools along the anterior-posterior axis of the spinal cord.
“After their generation, MNs diversify and organise into distinct columns and pools along the anterior-posterior axis of the spinal cord”
From Single cell transcriptomics reveals spatial and temporal dynamics of gene expression in the developing mouse spinal cord (2019) · cites this paper as Jessell, 2000
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- Authors
- Jessell, T. M.
- Affiliations
- Howard Hughes Medical Institute (US)
- Corresponding author
- Jessell, Thomas M.
- Venue
- Nature Reviews Genetics
- Published
- 2000-10
- Volume
- 1
- Issue
- 1
- Pages
- 20-29
- ISSN
- 1471-0056 (ISSN-L)
- 1471-0064
- OpenAlex
- W2081235375
- Cited by
- 2,089
- References
- 104
- Citations by year
- 2026: 36 · 2025: 46 · 2024: 41 · 2023: 45 · 2022: 64 · 2021: 57 · 2020: 88 · 2019: 64 · 2018: 64 · 2017: 62 · 2016: 76 · 2015: 80 · 2014: 80 · 2013: 103 · 2012: 100
- FWCI
- 5.90
- Type
- journal article
- Language
- en
- Open access
- closed
- Licence
- www.springer.com/tdm (tdm)
- Locations
- Nature Reviews Genetics (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Developmental Biology and Gene Regulation
- Life Sciences › Neuroscience › Developmental Neuroscience › Neurogenesis and neuroplasticity mechanisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Congenital heart defects research
- Keywords
- neuronal specification, spinal cord development, neural tube, cell fate determination, transcriptional regulation, neural progenitor cells, neural circuit formation, signaling molecules, vertebrate central nervous system
- MeSH terms
- Animals, Neurons, Spinal Cord, Transcription, Genetic, Cell Lineage
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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