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Bacterial Adhesion and Entry into Host Cells
Open accessAbstract
Successful establishment of infection by bacterial pathogens requires adhesion to host cells, colonization of tissues, and in certain cases, cellular invasion-followed by intracellular multiplication, dissemination to other tissues, or persistence. Bacteria use monomeric adhesins/invasins or highly sophisticated macromolecular machines such as type III secretion systems and retractile type IV pili to establish a complex host/pathogen molecular crosstalk that leads to subversion of cellular functions and establishment of disease.
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“For many microbial pathogens, invasion of host cells is critical for the initiation and maintenance of infection, and many of these organisms have more than one mechanism for inducing their own uptake by host cells [46].”
From Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells (2007) · cites this paper as [46]
In the citing paper
“For many microbial pathogens, invasion of host cells is critical for the initiation and maintenance of infection, and many of these organisms have more than one mechanism for inducing their own uptake by host cells [46].”
From Als3 Is a Candida albicans Invasin That Binds to Cadherins and Induces Endocytosis by Host Cells (2007) · cites this paper as [46]
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Enteropathogenic E. coli (EPEC) transfers its receptor for intimate adherence into mammalian cells.
Kenny, B., Devinney, R., Stein, M., Reinscheid, D., Frey, E., & Finlay, B. (1997) · Cell · doi:10.1016/s0092-8674(00)80437-7 · Cited by 1,258 · cited 1×
“…of the EPEC/ EHEC TTSS is Tir ( t ranslocated i ntimin r eceptor), which is injected into host target cells and then is inserted into the host-cell membrane, where it functions as a receptor for another LEE encoded molecule, the outer membrane protein intimin (Kenny et al., 1997)(Figure 3A).”
Helicobacter pylori Adhesin Binding Fucosylated Histo-Blood Group Antigens Revealed by Retagging
Ilver, D., Arnqvist, A., Ögren, J., Frick, I.-M., Kersulyte, D., Incecik, E. T., Berg, D. E., Covacci, A., Engstrand, L. G., & Borén, T. (1998) · Science · doi:10.1126/science.279.5349.373 · Cited by 1,225 · cited 1×
“BabA recognizes the Lewis b (Le b ) blood group antigen present on red blood cells and in the gastric mucosa (Ilver et al., 1998); inflammation of the gastric tissue leads to increased expression of other Lewis antigens normally expressed at low levels such as sialylated sLe x and sLe a , and H.…”
Intracellular Bacterial Biofilm-Like Pods in Urinary Tract Infections
Anderson, G. G., Palermo, J. J., Schilling, J. D., Roth, R. A., Heuser, J., & Hultgren, S. J. (2003) · Science · doi:10.1126/science.1084550 · Cited by 1,175 · cited 10×
“Cdc42 and RhoA are also required for the FimH-dependent cell invasion process by UPEC (Martinez and Hultgren, 2002).”
InfluentialBacterial Invasion: The Paradigms of Enteroinvasive Pathogens
Cossart, P., & Sansonetti, P. (2004) · Science · doi:10.1126/science.1090124 · Cited by 1,002 · cited 1×
“Both pathogens trigger important cytoskeletal changes at the host-cell plasma membrane to promote invasion (Cossart and Sansonetti, 2004).”
Self-citationSupramolecular structure of the Salmonella typhimurium type III protein secretion system.
Kubori, T., Matsushima, Y., Nakamura, D., Uralil, J., Lara-Tejero, M., Sukhan, A., Galán, J., & Aizawa, S. (1998) · Science · doi:10.1126/science.280.5363.602 · Cited by 972
Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation
Mahdavi, J., Sondén, B., Hurtig, M., Olfat, F. O., Forsberg, L., Roche, N., Ångström, J., Larsson, T. P., Teneberg, S., Karlsson, K., et al. (2002) · Science · doi:10.1126/science.1069076 · Cited by 935 · cited 1×
“…of other Lewis antigens normally expressed at low levels such as sialylated sLe x and sLe a , and H. pylori recognizes these molecules via the sialic acid binding protein (SabA) (Mahdavi et al., 2002), suggesting that H. pylori infection favors the expression of its own receptors in target tissues.”
Type V Protein Secretion Pathway: the Autotransporter Story
Henderson, I. R., Navarro‐García, F., Desvaux, M., Fernandez, R. C., & Ala’Aldeen, D. A. A. (2004) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.68.4.692-744.2004 · Cited by 873 · cited 1×
“…leader peptide for secretion across the inner membrane, a C-terminal domain that forms a pore in the outer membrane, and a passenger domain that is autotransported through the outer membrane pore to be exposed on the bacterial surface, for cleavage in certain cases (Henderson et al., 2004).”
Hardt, W., Chen, L., Schuebel, K. E., Bustelo, X. R., & Galán, J. E. (1998) · Cell · doi:10.1016/s0092-8674(00)81442-7 · Cited by 811 · cited 1×
“…effectors, SopE and SopE2, are bona fide guanine nucleotide exchange factors (GEFs) for Cdc42 and Rac1 and mimic host-cell GEFs, catalyzing the GTP loading and activation of these small GTPases, which results in formation of membrane extensions required for bacterial engulfment (Hardt et al., 1998).”
Isberg, R. R., & Leong, J. M. (1990) · Cell · doi:10.1016/0092-8674(90)90099-z · Cited by 798 · cited 1×
“Invasin is related to EPEC/EHEC intimins and binds with high affinity to multiple members of the b 1 chain integrin family (Isberg and Leong, 1990), subvert-ing normal interactions of these adhesion molecules with fibronectin.”
Type IV pilus structure and bacterial pathogenicity
Craig, L., Pique, M. E., & Tainer, J. A. (2004) · Nature Reviews Microbiology · doi:10.1038/nrmicro885 · Cited by 768 · cited 1×
“…of polymeric adhesive surface structures expressed by many Gram-negative bacteria including pathogens such as EPEC, EHEC, Salmonella enterica serovar Typhi, Pseudomonas aeruginosa, Legionella pneumophila, Neisseria gonorrhoeae , Neisseria meningitidis, and Vibrio cholerae (Craig et al., 2004).”
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Research works printed but not linked: 3
- Bruce-Staskal, 2002, Cas, Fak and Pyk2 function in diverse signaling cascades to promote Yersinia uptake, J. Cell Sci., 115, 2689, 10.1242/jcs.115.13.2689 · DOI
- Plancon, 2003, Recognition of the cellular beta1-chain integrin by the bacterial AfaD invasin is implicated in the internalization of afa-expressing pathogenic Escherichia coli strains, Cell. Microbiol., 5, 681, 10.1046/j.1462-5822.2003.00308.x · DOI
- Zhou, 2001, Uroplakin Ia is the urothelial receptor for uropathogenic Escherichia coli: evidence from in vitro FimH binding, J. Cell Sci., 114, 4095, 10.1242/jcs.114.22.4095 · DOI
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van der Wel, N., Hava, D., Houben, D., Fluitsma, D., van Zon, M., Pierson, J., Brenner, M., & Peters, P. J. (2007) · Cell · doi:10.1016/j.cell.2007.05.059 · Cited by 960
“The prevailing paradigm has remained that M. tuberculosis reside in the endocytic system (Orme, 2004; Vergne et al., 2004; Russell et al., 2002; Kang et al., 2005; Russell, 2001; Pizarro-Cerda and Cossart, 2006).”
BackgroundInflammasome adaptors and sensors: intracellular regulators of infection and inflammation
Mariathasan, S., & Monack, D. M. (2006) · Nature reviews. Immunology · doi:10.1038/nri1997 · Cited by 879
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Ribet, D., & Cossart, P. (2015) · Microbes and Infection · doi:10.1016/j.micinf.2015.01.004 · Cited by 788
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BackgroundUptake through glycoprotein 2 of FimH+ bacteria by M cells initiates mucosal immune response
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BackgroundBacterial outer membrane vesicles as a platform for biomedical applications: An update
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Filler, S. G., & Sheppard, D. C. (2006) · PLoS Pathogens · doi:10.1371/journal.ppat.0020129 · Cited by 275
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“One mechanism employed by bacteria to evade the host innate immune response is escape into the cytoplasm to avoid lysosomal killing [60,112].”
BackgroundClustering and Internalization of Integrin αvβ3 With a Tetrameric RGD-synthetic Peptide.
Lucie, S., Elisabeth, G., Stéphanie, F., Guy, S., Amandine, H., Corinne, A.-R., Didier, B., Catherine, S., Alexeï, G., Pascal, D., et al. (2009) · Molecular Therapy · doi:10.1038/mt.2009.29 · Cited by 137
“The integrin endo/exocytic cycle [25-27] suggests that there are, at least, three types of pathways associated with integrin internalization: 1/ clathrin-mediated endocytosis was described for αvβ5 integrins [28]; 2/ caveolae-mediated endocytosis for α2 integrins [29] and 3/ clathrin-caveolaeindependent endocytosis.”
BackgroundMolecular Chaperones in Pathogen Virulence: Emerging New Targets for Therapy
Neckers, L., & Tatu, U. S. (2008) · Cell Host & Microbe · doi:10.1016/j.chom.2008.10.011 · Cited by 146
Vadia, S., Arnett, E., Haghighat, A.-C., Wilson-Kubalek, E. M., Tweten, R. K., & Seveau, S. M. (2011) · PLoS Pathogens · doi:10.1371/journal.ppat.1002356 · Cited by 132
“Bacteria are known to induce their entry by activating host receptors or by injecting effectors into the host cell cytosol [1,2,70].”
BackgroundPrevention of bacterial adhesion
Klemm, P., Vejborg, R. M., & Hancock, V. (2010) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-010-2805-y · Cited by 134
“Most gram-negative and grampositive bacterial pathogens produce fimbriae (Foster 2004; Odenbreit 2005; Pizarro-Cerdá and Cossart 2006).”
BackgroundKang, M., & Martín, A. (2017) · Seminars in Immunology · doi:10.1016/j.smim.2017.04.003 · Cited by 143
“cadherin [35], receptors on the IECs [18], or components of the extracellular matrix [36,37].”
BackgroundMartinez, E., Cantet, F., Fava, L., Norville, I., & Bonazzi, M. (2014) · PLoS Pathogens · doi:10.1371/journal.ppat.1004013 · Cited by 131
Natural selection on the Drosophila antimicrobial immune system.
Lazzaro, B. (2008) · Current Opinion in Microbiology · doi:10.1016/j.mib.2008.05.001 · Cited by 131
“[44]).”
Structural basis of flocculin-mediated social behavior in yeast
Veelders, M., Brückner, S., Ott, D., Unverzagt, C., Mösch, H., & Essen, L. (2010) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1013210108 · Cited by 130
Geng, X., Sha, J., Liu, S.-K., Bao, L.-S., Zhang, J.-R., Wang, R.-J., Yao, J., Li, C., Feng, J.-B., Sun, F.-Y., et al. (2015) · BMC Genomics · doi:10.1186/s12864-015-1409-4 · Cited by 129
“PI3K is required for modifying the cytoskeleton dynamics, regulating membrane traffic, coordinating exocytic membrane insertion and pseudopod extension, which could be utilized by some pathogenic bacteria for entry into host cell [34-38].”
BackgroundMechanisms of Chlamydia trachomatis Entry into Nonphagocytic Cells
Hybiske, K., & Stephens, R. S. (2007) · Infection and Immunity · doi:10.1128/iai.00106-07 · Cited by 113
Regulation of surface architecture by symbiotic bacteria mediates host colonization
Liu, C. H., Lee, S. M., VanLare, J. M., Kasper, D. L., & Mazmanian, S. K. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0709266105 · Cited by 121
The role of clathrin-dependent endocytosis in bacterial internalization
Veiga, E., & Cossart, P. (2006) · Trends in Cell Biology · doi:10.1016/j.tcb.2006.08.005 · Cited by 123
Self-citationHippenstiel, S., Opitz, B., Schmeck, B., & Suttorp, N. (2006) · Respiratory Research · doi:10.1186/1465-9921-7-97 · Cited by 158
Koczan, J., Lenneman, B. R., Mcgrath, M., & Sundin, G. (2011) · Applied and Environmental Microbiology · doi:10.1128/aem.05138-11 · Cited by 124
Listeria monocytogenes internalin and E-cadherin: from structure to pathogenesis
Bonazzi, M., Lecuit, M., & Cossart, P. (2009) · Cellular Microbiology · doi:10.1111/j.1462-5822.2009.01293.x · Cited by 118
Self-citationKrishnan, V., Gaspar, A. H., Ye, N., Mandlik, A., Ton‐That, H., & Narayana, S. V. L. (2007) · Structure · doi:10.1016/j.str.2007.06.015 · Cited by 119
“Conclusions Adherence to specific host tissues is instrumental for many bacterial pathogens to mount successful colonization of humans (Pizarro-Cerda and Cossart, 2006).”
BackgroundThe interaction of macrophage receptors with bacterial ligands
Plüddemann, A., Mukhopadhyay, S., & Gordon, S. (2006) · Expert Reviews in Molecular Medicine · doi:10.1017/s1462399406000159 · Cited by 124
From Catheter to Kidney Stone: The Uropathogenic Lifestyle of Proteus mirabilis
Norsworthy, A. N., & Pearson, M. M. (2016) · Trends in Microbiology · doi:10.1016/j.tim.2016.11.015 · Cited by 128
“They can be involved in a number of processes such as biofilm formation, surface attachment, and evasion of the host immune response [52].”
Emerson, J., Reynolds, C., Fagan, R. P., Shaw, H., Goulding, D., & Fairweather, N. (2009) · Molecular Microbiology · doi:10.1111/j.1365-2958.2009.06812.x · Cited by 121
“In order to colonize their hosts, pathogenic bacteria must both evade the immune response and interact with host cells, often adhering to specific surface-localized molecules (Pizarro-Cerda and Cossart, 2006).”
BackgroundSillanpää, J., Nallapareddy, S. R., Prakash, V. P., Qin, X., Höök, M., Weinstock, G. M., & Murray, B. E. (2008) · Microbiology · doi:10.1099/mic.0.2008/017319-0 · Cited by 128
“It is known that pathogenic bacteria have evolved a plethora of proteins to adhere to and invade host tissues and to resist host defenses (Pizarro-Cerda & Cossart, 2006).”
BackgroundChen, H., Li, Y., Wang, Y., Ning, P., Shen, Y., Wei, X., Feng, Q., Liu, Y., Li, Z., Xu, C., et al. (2022) · ACS Nano · doi:10.1021/acsnano.1c11601 · Cited by 142
Small Molecules That Sabotage Bacterial Virulence
Johnson, B. K., & Abramovitch, R. B. (2017) · Trends in Pharmacological Sciences · doi:10.1016/j.tips.2017.01.004 · Cited by 135
“A pilus is a long multi-subunit appendage with binding specificity at the terminal subunits, typically through FimH or PapG, for a specific receptor on the host cell surface [81, 82, 85, 86].”
BackgroundA lipid zipper triggers bacterial invasion
Eierhoff, T., Bastian, B., Thuenauer, R., Madl, J., Audfray, A., Aigal, S., Juillot, S., Rydell, G., Müller, S. K., Debentzmann, S., et al. (2014) · Proceedings of the National Academy of Sciences of the United States of America · doi:10.1073/pnas.1402637111 · Cited by 120
Leon, J. D., Jiang, G., Ma, Y., Rubin, E. J., Fortune, S. M., & Sun, J. (2012) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.420869 · Cited by 125
Mölleken, K., & Hegemann, J. (2007) · Molecular Microbiology · doi:10.1111/j.1365-2958.2007.06050.x · Cited by 117
“These specific interactions may also help determine the cell and tissue tropism of the bacteria (Finlay and Falkow, 1989; Boyle and Finlay, 2003; Pizarro-Cerda and Cossart, 2006).”
BackgroundForoni, E., Serafini, F., Amidani, D., Turroni, F., He, F., Bottacini, F., Motherway, M. O., Viappiani, A., Zhang, Z., Rivetti, C., et al. (2011) · Microbial Cell Factories · doi:10.1186/1475-2859-10-s1-s16 · Cited by 121
Bacterial adhesins to host components in periodontitis
Amano, A. (2009) · Periodontology 2000 · doi:10.1111/j.1600-0757.2009.00307.x · Cited by 116
Against the tide: the role of bacterial adhesion in host colonization
Stones, D. H., & Krachler, A. M. (2016) · Biochemical Society Transactions · doi:10.1042/bst20160186 · Cited by 136
Marini, E., Magi, G., Mingoia, M., Pugnaloni, A., & Facinelli, B. (2015) · Frontiers in Microbiology · doi:10.3389/fmicb.2015.01281 · Cited by 132
“Successful establishment of GAS infection requires adhesion to host cells, colonization and, in certain cases, cell invasion followed by intracellular multiplication, dissemination, and/or persistence (Pizarro-Cerdá and Cossart, 2006).”
BackgroundFernandes, N. D., Case, R. J., Longford, S. R., Seyedsayamdost, M., Steinberg, P., Kjelleberg, S., & Thomas, T. (2011) · PLoS ONE · doi:10.1371/journal.pone.0027387 · Cited by 113
Ray, K., Bobard, A., Danckaert, A., Paz, I., Clair, C., Ehsani, S., Tang, C. M., Sansonetti, P. J., Nhieu, G. T. V., & Enninga, J. (2010) · Cellular Microbiology · doi:10.1111/j.1462-5822.2010.01428.x · Cited by 114
“Invasive pathogens, like Shigella flexneri, Salmonella enterica and Listeria monocytogenes, force their uptake into non-phagocytic host cells via tightly controlled mechanisms like endocytosis, phagocytosis or macropinocytosis (Conner and Schmid, 2003; Pizarro-Cerda and Cossart, 2006).”
BackgroundListeria monocytogenes Internalin and E-cadherin: From Bench to BedsidePreprint
Bonazzi, M., Lecuit, M., & Cossart, P. (2009) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a003087 · Cited by 107
“…epithelial cells is mainly mediated by two bacterial surface protein members of the internalin family, namely internalin (InlA) and InlB, that use E-cadherin and Met as receptors, respectively, on the surface of host cells (Hamon et al. 2006; Pizarro-Cerda and Cossart 2006; Bonazzi et al. 2009).”
BackgroundSelf-citationThe many niches and strategies used by pathogenic mycobacteria for survival within host macrophages
de Chastellier, C. (2009) · Immunobiology · doi:10.1016/j.imbio.2008.12.005 · Cited by 114
Back from the dead; the curious tale of the predatory cyanobacterium Vampirovibrio chlorellavorus
Soo, R., Woodcroft, B., Parks, D., Tyson, G., & Hugenholtz, P. (2015) · PeerJ · doi:10.7717/peerj.968 · Cited by 110
“V. chlorellavorus is the first recognised member of the Cyanobacteria with a predatory lifecycle and we predict that it is the first predator to use a conjugative type IV secretion system similar to Agrobacterium tumefaciens to invade its host.”
BackgroundXicohtencatl-Cortes, J., Monteiro-Neto, V., Saldaña, Z., Ledesma, M., Puente, J. L., & Girón, J. (2008) · Journal of Bacteriology · doi:10.1128/jb.01306-08 · Cited by 110
Modulation of Nod2-dependent NF-κB signaling by the actin cytoskeleton
Legrand-Poels, S., Kustermans, G., Bex, F., Kremmer, E., Kufer, T. A., & Piette, J. G. (2007) · Journal of Cell Science · doi:10.1242/jcs.03424 · Cited by 123
“Invasive pathogens induce their internalization through secreted proteins interfering with cytoskeleton machinery (for a review, see Pizarro-Cerda and Cossart, 2006).”
BackgroundSortase-Catalyzed Assembly of Distinct Heteromeric Fimbriae in Actinomyces naeslundii
Mishra, A., Das, A., Cisar, J. O., & Ton‐That, H. (2007) · Journal of Bacteriology · doi:10.1128/jb.01952-06 · Cited by 106
“This step generally depends on specific interactions of fimbriae or pili displayed on bacterial cell surfaces with distinct host cell receptors, which govern the bacterial host range and sites of infection (27, 34).”
BackgroundMethodIntestinally Secreted C-Type Lectin Reg3b Attenuates Salmonellosis but Not Listeriosis in Mice
van Ampting, M. T. J., Loonen, L., Schonewille, A., Konings, I. B. M., Vink, C., Iovanna, J., Chamaillard, M., Dekker, J., van der Meer, R. V. D., Wells, J., et al. (2012) · Infection and Immunity · doi:10.1128/iai.06165-11 · Cited by 108
“monocytogenes, internalin B, which enables Listeria to enter and survive within epithelial cells via interaction with three different epithelial membrane receptors (4, 19).”
BackgroundInfluential
Metadata
- Authors
- Pizarro-Cerdá, J., & Cossart, P.
- Affiliations
- Inserm (FR)
- Corresponding author
- Cossart, Pascale
- ORCID
- Cossart, Pascale
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2006-02
- Volume
- 124
- Issue
- 4
- Pages
- 715-727
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1965202893
- Cited by
- 977
- References
- 102
- Citations by year
- 2026: 36 · 2025: 60 · 2024: 48 · 2023: 42 · 2022: 49 · 2021: 75 · 2020: 66 · 2019: 67 · 2018: 52 · 2017: 56 · 2016: 48 · 2015: 43 · 2014: 55 · 2013: 31 · 2012: 37
- FWCI
- 4.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- Topics
- Life Sciences › Immunology and Microbiology › Microbiology › Escherichia coli research studies
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Biochemical and Structural Characterization
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
- Keywords
- bacterial adhesion, host cell invasion, type III secretion system, type IV pili, bacterial adhesins, intracellular bacterial growth, bacterial pathogenesis
- MeSH terms
- Bacteria, Bacterial Adhesion, Bacterial Outer Membrane Proteins, Epithelial Cells, Humans, Models, Biological, Fimbriae, Bacterial, Virulence Factors
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