Blimp1 Defines a Progenitor Population that Governs Cellular Input to the Sebaceous Gland
Open accessAbstract
Epidermal lineage commitment occurs when multipotent stem cells are specified to three lineages: the epidermis, the hair follicle, and the sebaceous gland (SG). How and when a lineage becomes specified remains unknown. Here, we report the existence of a population of unipotent progenitor cells that reside in the SG and express the transcriptional repressor Blimp1. Using cell-culture studies and genetic lineage tracing, we demonstrate that Blimp1-expressing cells are upstream from other cells of the SG lineage. Blimp1 appears to govern cellular input into the gland since its loss leads to elevated c-myc expression, augmented cell proliferation, and SG hyperplasia. Finally, BrdU labeling experiments demonstrate that the SG defects associated with loss of Blimp1 lead to enhanced bulge stem cell activity, suggesting that when normal SG homeostasis is perturbed, multipotent stem cells in the bulge can be mobilized to correct this imbalance.
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The SG has been proposed to be replenished by distinct pools of stem cells or progenitors located in the HF or base of the SG.
“The SG has been proposed to be replenished by distinct pools of stem cells or progenitors located in the HF or base of the SG3–7.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [3]
Blimp1+ cells reside at the base of the SG and function as a sebocyte progenitor population.
“Blimp1+ cells reside at the base of the SG and have been reported to function as a sebocyte progenitor population3.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [3]
c-Myc is a fundamental factor that governs sebaceous gland expansion in vivo.
“A fundamental factor that governs SG expansion in vivo is c-Myc3, 29–31,.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [3]
Prior findings show that overexpression of c-Myc leads to enhanced SG expansion, while conditional deletion of c-Myc results in decreased SG size, cell proliferation, and sebocyte differentiation.
“previously reported findings where overexpression of c-Myc led to enhanced SG expansion, while conditional deletion of c-Myc resulted in decreased SG size, cell proliferation, and sebocyte differentiation3, 29, 38, 39.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [3]
Blimp1+ cells reside exclusively at the base of the sebaceous gland and serve as a pool of progenitors.
“Initially, it was reported that Blimp1+ cells reside exclusively at the base of the SG and serve as a pool of progenitors3.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [3]
Blimp1 governs the size of sebaceous glands by repressing c-Myc gene expression.
“Blimp1 has been shown to govern the size of SGs by repressing c-Myc gene expression3.”
From Blimp1+ cells generate functional mouse sebaceous gland organoids in vitro (2019) · cites this paper as [3]
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References 44 · Cited by 426
- Authors
- Horsley, V., O'Carroll, D., Tooze, R., Ohinata, Y., Saitou, M., Obukhanych, T., Nussenzweig, M., Tarakhovsky, A., & Fuchs, E.
- Affiliations
- Howard Hughes Medical Institute (US)
- University of Leeds (GB)
- RIKEN (JP)
- Rockefeller University (US)
- Corresponding author
- Fuchs, Elaine
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2006-08
- Volume
- 126
- Issue
- 3
- Pages
- 597-609
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2424190
- OpenAlex
- W2127292451
- Cited by
- 426
- References
- 44
- Citations by year
- 2026: 10 · 2025: 8 · 2024: 9 · 2023: 11 · 2022: 17 · 2021: 10 · 2020: 13 · 2019: 19 · 2018: 15 · 2017: 22 · 2016: 25 · 2015: 18 · 2014: 32 · 2013: 41 · 2012: 35
- FWCI
- 28.26
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institutes of Health (2r01ar050452-21)
- National Institute of Arthritis and Musculoskeletal and Skin Diseases (R01AR031737, R01-AR050452)
- Topics
- Health Sciences › Medicine › Urology › Hair Growth and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and rare skin diseases.
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cell Biology › Skin and Cellular Biology Research
- Keywords
- Blimp-1, sebaceous glands, c-Myc, sebaceous hyperplasia, bulge stem cells, stem cell mobilization, transcriptional repressor, hair follicle, epidermis
- MeSH terms
- Positive Regulatory Domain I-Binding Factor 1, Animals, Animals, Newborn, Bromodeoxyuridine, Cell Count, Cell Differentiation, Cell Movement, Cells, Cultured, Epithelial Cells, Hyperplasia, Mice, Transgenic, Repressor Proteins, Sebaceous Glands, Stem Cells, Transcription Factors, Proto-Oncogene Proteins c-myc, Mice, Knockout, Gene Expression Regulation, Developmental, Hair Follicle, Cell Lineage, Multipotent Stem Cells, Cell Proliferation, Mice
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