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Nuclear Actions in Innate Immune Signaling
Open accessAbstract
Innate immunity in plants and animals is mediated through pattern recognition receptors, which were thought to initiate signaling in the cytoplasm to activate defense pathways. Shen et al. (2006) and Burch-Smith et al. (2007) now provide compelling evidence that certain plant disease resistance proteins, which detect specific pathogenic effectors, act in the nucleus to trigger downstream signaling and defense pathways.
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“Interestingly, intracellular effectors with TIR-like domains have been recently shown to enter the nucleus and to regulate immune-like response in plants, acting on WRKY transcription factors, which negatively regulate such response [54,66,68].”
From Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium (2008) · cites this paper as [68]
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“TIR-like proteins, among which are Toll receptors, are major regulators of phagocytosis and pathogen-response in animals [54,66-68].”
From Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium (2008) · cites this paper as [68]
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Research works printed but not linked: 10
- Burch-Smith, 2007, PLoS Biol., 5, e68, 10.1371/journal.pbio.0050068 · DOI · Paper page
- Chisholm, 2006, Cell, 124, 803, 10.1016/j.cell.2006.02.008 · DOI · Paper page
- DeYoung, 2006, Nat. Immunol., 7, 1243, 10.1038/ni1410 · DOI
- Jones, 2006, Nature, 444, 323, 10.1038/nature05286 · DOI · Paper page
- Mestre, 2006, Plant Cell, 18, 491, 10.1105/tpc.105.037234 · DOI
- Shen, 2006, Science
- Ting, 2006, Nat. Rev. Immunol., 6, 183, 10.1038/nri1788 · DOI
- Ueda, 2006, Plant Mol. Biol., 61, 31, 10.1007/s11103-005-5817-8 · DOI
- Wang, 2006, PLoS Pathogens, 2, e123, 10.1371/journal.ppat.0020123 · DOI
- Xu, 2006, Plant Cell, 18, 1310, 10.1105/tpc.105.037523 · DOI
Cited by
Sorted by citations
Genome-wide transcriptional changes induced by phagocytosis or growth on bacteria in Dictyostelium
Sillo, A., Bloomfield, G., Balest, A., Balbo, A., Pergolizzi, B., Peracino, B., Skelton, J., Ivens, A., & Bozzaro, S. (2008) · BMC Genomics · doi:10.1186/1471-2164-9-291 · Cited by 69
Metadata
- Authors
- Sheen, J., & He, P.
- Affiliations
- Harvard University (US)
- Corresponding author
- Sheen, Jen
- ORCID
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2007-03
- Volume
- 128
- Issue
- 5
- Pages
- 821-823
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2113711942
- Cited by
- 12
- References
- 0
- Citations by year
- 2025: 1 · 2017: 1 · 2016: 1 · 2014: 1 · 2012: 2
- FWCI
- 2.43
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2330 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Pathogenic Bacteria Studies
- Keywords
- innate immunity, pattern recognition receptors, disease resistance proteins, nuclear signaling, plant defense, cytoplasmic signaling
- MeSH terms
- Animals, Hordeum, Cell Nucleus, Immunity, Innate, Plant Diseases, Plants, Nicotiana, Signal Transduction, Receptors, Pattern Recognition
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