The DOI matches its Crossref record; 46 of the 46 references it cites were found in a registry or an index.
Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
Open accessAbstract
Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
In the citing paper
“Proposed drivers of physiological aging include the accumulation of DNA damage, increased ROS production, telomere shortening, cellular senescence, and defects in nuclear envelope architecture (Bernardes de Jesus and Blasco, 2013;Guarente, 2008;Haigis and Sinclair, 2009;Kennedy and Lamming, 2016;Soultoukis and Partridge, 2016;Steffen and Dillin, 2016).”
From In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming. (2016) · cites this paper as Guarente, 2008
Experimental — accuracy not yet measuredIn the citing paper
“Aged tissues show accumulation of mitochondrial DNA (mtDNA) mutations causing respiratory chain deficiency and increased reactive oxygen species (ROS)2,4”
From Telomere dysfunction induces metabolic and mitochondrial compromise (2011) · cites this paper as [4]
In the citing paper
“Sirtuins have been implicated in the mechanism of lifespan extension by CR [65] and SIRT1 is regulated by CR in mice in a tissue specific manner [66].”
From PGC-1α in aging and anti-aging interventions (2009) · cites this paper as [65]
In the citing paper
“Although CR has been proposed to increase mitochondrial content (Guarente, 2008), no impact of CR on mitochondrial density could be evidenced in the present study.”
From Effects of Aging and Caloric Restriction on Fiber Type Composition, Mitochondrial Morphology and Dynamics in Rat Oxidative and Glycolytic Muscles (2019) · cites this paper as Guarente, 2008
In the citing paper
“How this is related to mitochondrial function is not clear, but evidence suggests that calorie restriction favors mitochondrial biogenesis, oxygen use and ATP formation, and expression of SIRT1, which activates PGC1-α (121, 203).”
From Mitochondrial Dysfunction in Diabetes: From Molecular Mechanisms to Functional Significance and Therapeutic Opportunities (2010) · cites this paper as [121]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Aging: a theory based on free radical and radiation chemistry
Harman, D. (1956) · Journal of Gerontology · doi:10.1093/geronj/11.3.298 · Cited by 8,567
Role of AMP-Activated Protein Kinase in Mechanism of Metformin Action
Zhou, G., Myers, R., Li, Y., Chen, Y., Shen, X., Fenyk-Melody, J., Wu, M., Ventre, J., Doebber, T., Fujii, N., et al. (2001) · Journal of Clinical Investigation · doi:10.1172/jci13505 · Cited by 5,652
Resveratrol improves health and survival of mice on a high-calorie diet
Baur, J. A., Pearson, K. J., Price, N. L., Jamieson, H. A., Lerin, C., Kalra, A., Prabhu, V. V., Allard, J. S., Lopez-Lluch, G., Lewis, K., et al. (2006) · Nature · doi:10.1038/nature05354 · Cited by 4,290
Lagouge, M., Argmann, C., Gerhart-Hines, Z., Meziane, H., Lerin, C., Daussin, F., Messadeq, N., Milne, J., Lambert, P., Elliott, P., et al. (2006) · Cell · doi:10.1016/j.cell.2006.11.013 · Cited by 4,057
Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase
Imai, S.-I., Armstrong, C. M., Kaeberlein, M., & Guarente, L. (2000) · Nature · doi:10.1038/35001622 · Cited by 3,510
Self-citationWallace, D. C. (2005) · Annual Review of Genetics · doi:10.1146/annurev.genet.39.110304.095751 · Cited by 3,185
Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1
Rodgers, J. T., Lerin, C., Haas, W., Gygi, S. P., Spiegelman, B. M., & Puigserver, P. (2005) · Nature · doi:10.1038/nature03354 · Cited by 3,160
Premature ageing in mice expressing defective mitochondrial DNA polymerase
Trifunovic, A., Wredenberg, A., Falkenberg, M., Spelbrink, J. N., Rovio, A. T., Bruder, C. E., Bohlooly-Y, M., Gidlöf, S., Oldfors, A., Wibom, R., et al. (2004) · Nature · doi:10.1038/nature02517 · Cited by 2,734
Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging
Kujoth, G. C., Hiona, A., Pugh, T. D., Someya, S., Panzer, K., Wohlgemuth, S. E., Hofer, T., Seo, A. Y., Sullivan, R., Jobling, W. A., et al. (2005) · Science · doi:10.1126/science.1112125 · Cited by 2,165
OWEN, M. R., DORAN, E., & HALESTRAP, A. P. (2000) · Biochemical Journal · doi:10.1042/bj3480607 · Cited by 2,157
Flagged first, then by citations
Research works printed but not linked: 1
- Lee, 2007, Proc. Natl. Acad. Sci. USA
Cited by
Sorted by citations
Items 501–512 of 512
Glycolysis in adipose tissue-dependent thermogenesis
Topete, M., Pereira, S. S., Andrade, S., Oliveira, S. B., & Monteiro, M. P. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-91704-9.00019-7
Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular LifespanPreprint
Oz, N., Su, H., Sari, V., Patnaik, P. K., Hameed, R., Song, J. H., Prosser, D. C., Labunskyy, V. M., Gladyshev, V. N., Hao, N., et al. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.04.14.648769 · Cited by 1
Gupta, S. K., Gupta, A., Kansal, D., Kumar, D., & Patil, V. M. (2025) · Springer eBooks · doi:10.1007/978-981-96-6831-1_8
RetractedRasińska, A., Rzyczniok, P., Bala, P., Jachimczak, J., Kopczyński, M., & Matusik, J. (2025) · Humanities & Social Sciences Reviews · doi:10.18510/hssr.2025.13216
Song, Y., Zhang, J., Luo, Z., Wu, L., Cai, Z., Zhong, X., Zeng, X., Cao, T., Chen, H., Xu, S., et al. (2024) · Figshare · doi:10.6084/m9.figshare.26409940
Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular LifespanPreprint
Oz, N., Su, H., Sari, V., Patnaik, P. K., Hameed, R., Song, J. H., Prosser, D. C., Labunskyy, V. M., Gladyshev, V. N., Hao, N., et al. (2026) · eLife · doi:10.7554/elife.109761.1
Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular LifespanPreprint
Oz, N., Su, H., Sari, V., Patnaik, P. K., Hameed, R., Song, J. H., Prosser, D. C., Labunskyy, V. M., Gladyshev, V. N., Hao, N., et al. (2026) · eLife · doi:10.7554/elife.109761
Written in development and lost in ageing: the grammar of cellular identity
Yücel, A. D., Molière, A., & Gladyshev, V. N. (2026) · Nature · doi:10.1038/s41586-026-10955-0 · Cited by 1
Engineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular LifespanPreprint
Oz, N., Su, H., Sarı, V., Patnaik, P. K., Hameed, R., Song, J. H., Prosser, D. C., Labunskyy, V. M., Gladyshev, V. N., Hao, N., et al. (2026) · eLife · doi:10.7554/elife.109761.2
Links between Aging and Proteostasis Decline in Saccharomyces cerevisiae
Andersson, V. (2014) · Gothenburg University Publications Electronic Archive (Gothenburg University)
Bruss, M. D. (2011) · eScholarship (California Digital Library)
Metadata
- Authors
- Guarente, L.
- Affiliations
- Massachusetts Institute of Technology (US)
- Corresponding author
- Guarente, Leonard
- ORCID
- Guarente, Leonard
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-01
- Volume
- 132
- Issue
- 2
- Pages
- 171-176
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC2680180
- OpenAlex
- W2066762257
- Cited by
- 513
- References
- 46
- Citations by year
- 2026: 5 · 2025: 14 · 2024: 10 · 2023: 11 · 2022: 13 · 2021: 20 · 2020: 28 · 2019: 20 · 2018: 24 · 2017: 17 · 2016: 22 · 2015: 22 · 2014: 46 · 2013: 46 · 2012: 42
- FWCI
- 4.83
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 2024 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- Europe PMC (PubMed Central) (acceptedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute on Aging (R01AG015339, R01AG011119)
- Topics
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Mitochondrial Function and Pathology
- Keywords
- mitochondria, caloric restriction, sirtuins, aging, dietary restriction, mitochondrial activity, age-related diseases
- MeSH terms
- Aging, Animals, Humans, Mitochondria, Models, Biological, Caloric Restriction, Sirtuins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
