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Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent Genes
Open accessAbstract
Nuclear transcription is not restricted to genes, but occurs throughout the intergenic and noncoding space of eukaryotic genomes. The functional significance of this widespread noncoding transcription is mostly unknown. We show that Arabidopsis RNA Polymerase IVb/Pol V, a multi-subunit nuclear enzyme required for siRNA-mediated gene silencing of transposons and other repeats, transcribes intergenic and noncoding sequences, thereby facilitating heterochromatin formation and silencing of overlapping and adjacent genes. Pol IVb/Pol V transcription requires the chromatin remodeling protein, DRD1 but is independent of siRNA biogenesis. However, Pol IVb/Pol V transcription and siRNA production are both required to silence transposons, suggesting that Pol IVb/Pol V generates RNAs or chromatin structures that serve as scaffolds for siRNA-mediated heterochromatin forming complexes. Pol IVb/Pol V function provides a solution to a paradox of epigenetic control: the need for transcription in order to transcriptionally silence the same region.
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Cites
Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method
Livak, K. J., & Schmittgen, T. D. (2001) · Methods · doi:10.1006/meth.2001.1262 · Cited by 180,860
Cited by
Small RNAs as Guardians of the Genome
Malone, C. D., & Hannon, G. J. (2009) · Cell · doi:10.1016/j.cell.2009.01.045 · Cited by 836
Regulation and function of DNA methylation in plants and animals
He, X.-J., Chen, T., & Zhu, J.-K. (2011) · Cell Research · doi:10.1038/cr.2011.23 · Cited by 555
Epigenetic Regulation in Plants
Pikaard, C. S., & Mittelsten Scheid, O. (2014) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a019315 · Cited by 440
Self-citationErdmann, R. M., & Picard, C. L. (2020) · PLOS Genetics · doi:10.1371/journal.pgen.1009034 · Cited by 389
Multi-level engineering facilitates the production of phenylpropanoid compounds in tomato
Zhang, Y., Butelli, E., Alseekh, S., Tohge, T., Rallapalli, G., Luo, J., Kawar, P. G., Hill, L., Santino, A., Fernie, A. R., et al. (2015) · Nature Communications · doi:10.1038/ncomms9635 · Cited by 365
Metadata
- Authors
- Wierzbicki, A. T., Haag, J. R., & Pikaard, C. S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-11
- Volume
- 135
- Issue
- 4
- Pages
- 635-648
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2007250559
- Cited by
- 701
- References
- 1
- FWCI
- 49.36
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Wierzbicki, A. T., Haag, J. R., & Pikaard, C. S. (2008). Noncoding Transcription by RNA Polymerase Pol IVb/Pol V Mediates Transcriptional Silencing of Overlapping and Adjacent Genes. Cell. https://doi.org/10.1016/j.cell.2008.09.035
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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