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AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations
Open accessAbstract
Chromosomal translocation requires formation of paired double strand DNA breaks (DSBs) on heterologous chromosomes. One of the most well characterized oncogenic translocations juxtaposes c-myc and the immunoglobulin heavy chain locus (IgH) and is found in Burkitt’s lymphomas in humans and plasmacytomas in mice. DNA breaks in IgH leading to c-myc/IgH translocations are created by activation induced cytidine deaminase (AID) during antibody class switch recombination or somatic hypermutation. However, the source of DNA breaks at c-myc is not known. Here we provide evidence for the c-myc promoter region being required in targeting AID-mediated DNA damage to produce DSBs in c-myc that lead to c-myc/IgH translocations in primary B lymphocytes. Thus, in addition to producing somatic mutations and DNA breaks in antibody genes, AID is also responsible for the DNA lesions in oncogenes that are required for their translocation.
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Cites
Frequent chromosomal translocations induced by DNA double-strand breaks
Richardson, C., & Jasin, M. (2000) · Nature · doi:10.1038/35015097 · Cited by 517
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Self-citationAukema, S. M., Siebert, R., Schuuring, E., van Imhoff, G. W., Kluin-Nelemans, H. C., Boerma, E.-J., & Kluin, P. M. (2011) · Blood · doi:10.1182/blood-2010-09-297879 · Cited by 678
Lin, C., Yang, L., Tanasa, B., Hutt, K., Ju, B.-G., Ohgi, K. A., Zhang, J., Rose, D. W., Fu, X.-D., Glass, C. K., et al. (2009) · Cell · doi:10.1016/j.cell.2009.11.030 · Cited by 576
Lenz, G., & Staudt, L. M. (2010) · New England Journal of Medicine · doi:10.1056/nejmra0807082 · Cited by 528
Schwickert, T. A., Victora, G. D., Fooksman, D. R., Kamphorst, A. O., Mugnier, M. R., Gitlin, A. D., Dustin, M. L., & Nussenzweig, M. C. (2011) · Journal of Experimental Medicine · doi:10.1084/jem.20102477 · Cited by 438
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Metadata
- Authors
- Robbiani, D. F., Bothmer, A., Callen, E., Reina-San-Martin, B., Dorsett, Y., Difilippantonio, S., Bolland, D. J., Chen, H. T., Corcoran, A. E., Nussenzweig, A., & Nussenzweig, M. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2008-12
- Volume
- 135
- Issue
- 6
- Pages
- 1028-1038
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2060236569
- Cited by
- 467
- References
- 1
- FWCI
- 12.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations. https://app.cochat.ai/papers/10.1016/j.cell.2008.09.062
- The paper
- Robbiani, D. F., Bothmer, A., Callen, E., Reina-San-Martin, B., Dorsett, Y., Difilippantonio, S., Bolland, D. J., Chen, H. T., Corcoran, A. E., Nussenzweig, A., & Nussenzweig, M. C. (2008). AID Is Required for the Chromosomal Breaks in c-myc that Lead to c-myc/IgH Translocations. Cell. https://doi.org/10.1016/j.cell.2008.09.062
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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