The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
A General O-Glycosylation System Important to the Physiology of a Major Human Intestinal Symbiont
Open accessAbstract
SUMMARY The Bacteroides are a numerically dominant genus of the human intestinal microbiota. These organisms harbor a rare bacterial pathway for incorporation of exogenous fucose into capsular polysaccharides and glycoproteins. The infrequency of glycoprotein synthesis by bacteria prompted a more detailed analysis of this process. Here, we demonstrate that Bacteroides fragilis has a general O-glycosylation system. The proteins targeted for glycosylation include those predicted to be involved in protein folding, protein-protein interactions, peptide degradation, as well as surface lipoproteins. Protein glycosylation is central to the physiology of B. fragilis and is necessary for the organism to competitively colonize the mammalian intestine. We provide evidence that general O-glycosylation systems are conserved among intestinal Bacteroides species and likely contribute to the predominance of Bacteroides in the human intestine.
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Cited by
Protein glycosylation in bacteria: sweeter than ever
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Enzymes in the Synthesis of Glycoconjugates
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Mechanisms of disease: The human N-glycome
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Identification of trypsin-degrading commensals in the large intestine
Li, Y., Watanabe, E., Kawashima, Y., Plichta, D. R., Wang, Z., Ujike, M., Ang, Q. Y., Wu, R., Furuichi, M., Takeshita, K., et al. (2022) · Nature · doi:10.1038/s41586-022-05181-3 · Cited by 106
Phosphonate production by marine microbes: exploring new sources and potential function
Acker, M., Hogle, S. L., Berube, P. M., Hackl, T., Coe, A., Stepanauskas, R., Chisholm, S. W., & Repeta, D. J. (2022) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.2113386119 · Cited by 76
Metadata
- Authors
- Fletcher, C. M., Coyne, M. J., Villa, O. F., Chatzidaki-Livanis, M., & Comstock, L. E.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 137
- Issue
- 2
- Pages
- 321-331
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2069692343
- Cited by
- 168
- References
- 8
- FWCI
- 4.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Fletcher, C. M., Coyne, M. J., Villa, O. F., Chatzidaki-Livanis, M., & Comstock, L. E. (2009). A General O-Glycosylation System Important to the Physiology of a Major Human Intestinal Symbiont. Cell. https://doi.org/10.1016/j.cell.2009.02.041
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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