The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins
Open accessAbstract
SUMMARY Prions are proteins that convert between structurally and functionally distinct states, one or more of which is transmissible. In yeast, this ability allows them to act as non-Mendelian elements of phenotypic inheritance. To further our understanding of prion biology, we conducted a bioinformatic proteome-wide survey for prionogenic proteins in S. cerevisiae, followed by experimental investigations of 100 prion candidates. We found an unexpected amino acid bias in aggregation-prone candidates and discovered that 19 of these could also form prions. At least one of these prion proteins, Mot3, produces a bona fide prion in its natural context that increases population-level phenotypic heterogeneity. The self-perpetuating states of these proteins present a vast source of heritable phenotypic variation that increases the adaptability of yeast populations to diverse environments.
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Cites
Prions as adaptive conduits of memory and inheritance
Shorter, J., & Lindquist, S. (2005) · Nature Reviews Genetics · doi:10.1038/nrg1616 · Cited by 555
Self-citationAbramova, N., Sertil, O., Mehta, S., & Lowry, C. V. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.9.2881-2887.2001 · Cited by 157
Hongay, C., Jia, N., Bard, M., & Winston, F. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf415 · Cited by 72
Cited by
Alberti, S., Gladfelter, A., & Mittag, T. (2019) · Cell · doi:10.1016/j.cell.2018.12.035 · Cited by 2,856
Self-citationKato, M., Han, T. W., Xie, S., Shi, K., Du, X., Wu, L. C., Mirzaei, H., Goldsmith, E. J., Longgood, J., Pei, J., et al. (2012) · Cell · doi:10.1016/j.cell.2012.04.017 · Cited by 2,012
Cai, X., Chen, J., Xu, H., Liu, S., Jiang, Q.-X., Halfmann, R., & Chen, Z. J. (2014) · Cell · doi:10.1016/j.cell.2014.01.063 · Cited by 567
Self-citationKroschwald, S., Maharana, S., Mateju, D., Malinovska, L., Nüske, E., Poser, I., Richter, D., & Alberti, S. (2015) · eLife · doi:10.7554/elife.06807 · Cited by 560
Self-citationLeeman, D. S., Hebestreit, K., Ruetz, T., Webb, A. E., McKay, A., Pollina, E. A., Dulken, B. W., Zhao, X., Yeo, R. W., Ho, T. T., et al. (2018) · Science · doi:10.1126/science.aag3048 · Cited by 528
Metadata
- Authors
- Alberti, S., Halfmann, R., King, O., Kapila, A., & Lindquist, S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 137
- Issue
- 1
- Pages
- 146-158
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2119651404
- Cited by
- 968
- References
- 3
- FWCI
- 21.96
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Alberti, S., Halfmann, R., King, O., Kapila, A., & Lindquist, S. (2009). A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins. Cell. https://doi.org/10.1016/j.cell.2009.02.044
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