Reciprocal Regulation of Anaerobic and Aerobic Cell Wall Mannoprotein Gene Expression in Saccharomyces cerevisiae

Abramova, Natalia; Sertil, Odeniel; Mehta, Sapna; Lowry, Charles V.

doi:10.1128/jb.183.9.2881-2887.2001

Cited by 157Fungal and yeast genetics researchBacterial Genetics and BiotechnologyYeasts and Rust Fungi Studies

Reciprocal Regulation of Anaerobic and Aerobic Cell Wall Mannoprotein Gene Expression in Saccharomyces cerevisiae

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Abramova, Natalia, Sertil, Odeniel, Mehta, Sapna, Lowry, Charles V.·2001·Journal of Bacteriology

DOI 10.1128/jb.183.9.2881-2887.2001PMC PMC99506

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Abstract

The DAN/TIR genes encode nine cell wall mannoproteins in Saccharomyces cerevisiae which are expressed during anaerobiosis (DAN1, DAN2, DAN3, DAN4, TIR1, TIR2, TIR3, TIR4, and TIP1). Most are expressed within an hour of an anaerobic shift, but DAN2 and DAN3 are expressed after about 3 h. At the same time, CWP1 and CWP2, the genes encoding the major mannoproteins, are down-regulated, suggesting that there is a programmed remodeling of the cell wall in which Cwp1 and Cwp2 are replaced by nine anaerobic counterparts. TIP1, TIR1, TIR2, and TIR4 are also induced during cold shock. Correspondingly, CWP1 is down-regulated during cold shock. As reported elsewhere, Mox4 is a heme-inhibited activator, and Mot3 is a heme-induced repressor of the DAN/TIR genes (but not of TIP1). We show that CWP2 (but not CWP1) is controlled by the same factors, but in reverse fashion-primarily by Mot3 (which can function as either an activator or repressor) but also by Mox4, accounting for the reciprocal regulation of the two groups of genes. Disruptions of TIR1, TIR3, or TIR4 prevent anaerobic growth, indicating that each protein is essential for anaerobic adaptation. The Dan/Tir and Cwp proteins are homologous, with the greatest similarities shown within three subgroups: the Dan proteins, the Tip and Tir proteins, and, more distantly, the Cwp proteins. The clustering of homology corresponds to differences in expression: the Tip and Tir proteins are expressed during hypoxia and cold shock, the Dan proteins are more stringently repressed by oxygen and insensitive to cold shock, and the Cwp proteins are oppositely regulated by oxygen and temperature.

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Mot3 represses the expression of hypoxic, DAN/TIR/PAU and ERG genes including ERG2, ERG6 and ERG9.
“In addition, to limit Ecm22 function [75], the transcriptional factor Mot3 also represses the expression of hypoxic, DAN/TIR/PAU and ERG genes including ERG2, ERG6 and ERG9 (Figure 3A) [86,89,90,91,92,93].”
From Regulation of Ergosterol Biosynthesis in Saccharomyces cerevisiae (2020) · cites this paper as [91]

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Authors: Abramova, N., Sertil, O., Mehta, S., & Lowry, C. V.
Affiliations: Albany Medical College (US)
Venue: Journal of Bacteriology
Publisher: American Society for Microbiology
Published: 2001-05
Volume: 183
Issue: 9
Pages: 2881-2887
ISSN: 0021-9193 (ISSN-L)
1098-5530
DOI: 10.1128/jb.183.9.2881-2887.2001
PMC: PMC99506
OpenAlex: W2141260639
Cited by: 157
References: 36
Citations by year: 2026: 1 · 2025: 5 · 2024: 8 · 2023: 1 · 2022: 6 · 2021: 7 · 2020: 7 · 2019: 6 · 2018: 2 · 2017: 9 · 2016: 1 · 2015: 5 · 2014: 3 · 2013: 11 · 2012: 9
FWCI: 2.10
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Licence: journals.asm.org/non-commercial-tdm-license (tdm)
Locations: Journal of Bacteriology (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Foundation
U.S. Department of State
Topics: Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Fungal and yeast genetics research
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Bacterial Genetics and Biotechnology
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Yeasts and Rust Fungi Studies
Keywords: cell wall mannoproteins, TIP1, anaerobic adaptation, hypoxia, cold shock, gene expression regulation, oxygen regulation, reciprocal gene regulation, Saccharomyces cerevisiae, cell wall remodeling, protein homology
MeSH terms: Aerobiosis, Anaerobiosis, Cell Wall, Fungal Proteins, Genes, Fungal, Glycoproteins, Heat-Shock Proteins, Membrane Glycoproteins, Membrane Proteins, RNA, Fungal, RNA, Messenger, Saccharomyces cerevisiae, Temperature, Trans-Activators, Down-Regulation, Up-Regulation, Gene Expression Regulation, Fungal, Sequence Homology, Saccharomyces cerevisiae Proteins

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Reciprocal Regulation of Anaerobic and Aerobic Cell Wall Mannoprotein Gene Expression in Saccharomyces cerevisiae

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