The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism
Open accessAbstract
Notch signaling regulates many aspects of metazoan development and tissue renewal. Accordingly, misregulation or loss of Notch signaling underlies multiple human disorders, from developmental syndromes to adult onset diseases and cancer. Notch receptor activation is irreversible as it involves proteolysis-mediated release of the Notch intracellular domain, translocation to the nucleus, and association with a DNA-bound protein. Even though each Notch molecule signals only once without amplification by secondary messenger cascades, Notch signaling is remarkably robust in most tissues. In this review, we highlight the recent studies that reveal new molecular details involved in regulating ligand-mediated activation, receptor proteolysis and target selection.
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Cites
Mutations in NOTCH1 cause aortic valve disease
Garg, V., Muth, A. N., Ransom, J. F., Schluterman, M. K., Barnes, R., King, I. N., Grossfeld, P. D., & Srivastava, D. (2005) · Nature · doi:10.1038/nature03940 · Cited by 1,509
Inhibition of Dll4 signalling inhibits tumour growth by deregulating angiogenesis
Ridgway, J., Zhang, G., Wu, Y., Stawicki, S., Liang, W.-C., Chanthery, Y., Kowalski, J., Watts, R. J., Callahan, C., Kasman, I., et al. (2006) · Nature · doi:10.1038/nature05313 · Cited by 986
The N-end rule: functions, mysteries, uses
Varshavsky, A. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.22.12142 · Cited by 859
Qi-Takahara, Y., Morishima-Kawashima, M., Tanimura, Y., Dolios, G., Hirotani, N., Horikoshi, Y., Kametani, F., Maeda, M., Saido, T. C., Wang, R., et al. (2005) · The Journal of Neuroscience · doi:10.1523/jneurosci.1575-04.2005 · Cited by 391
Regulation of Notch Signaling by O-Linked Fucose
Okajima, T., & Irvine, K. D. (2002) · Cell · doi:10.1016/s0092-8674(02)01114-5 · Cited by 386
Protein O -fucosyltransferase 1 is an essential component of Notch signaling pathways
Shi, S., & Stanley, P. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0831126100 · Cited by 381
Rumi Is a CAP10 Domain Glycosyltransferase that Modifies Notch and Is Required for Notch Signaling
Acar, M., Jafar-Nejad, H., Takeuchi, H., Rajan, A., Ibrani, D., Rana, N. A., Pan, H., Haltiwanger, R. S., & Bellen, H. J. (2008) · Cell · doi:10.1016/j.cell.2007.12.016 · Cited by 306
Part-Time α-Secretases: The Functional Biology of ADAM 9, 10 and 17
Deuss, M., Reiss, K., & Hartmann, D. (2008) · Current Alzheimer Research · doi:10.2174/156720508783954686 · Cited by 98
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Bray, S. J. (2016) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm.2016.94 · Cited by 1,012
Zhou, D., Huang, C., Lin, Z., Zhan, S., Kong, L., Fang, C., & Li, J. (2014) · Cellular Signalling · doi:10.1016/j.cellsig.2013.11.004 · Cited by 778
Imayoshi, I., Sakamoto, M., Yamaguchi, M., Mori, K., & Kageyama, R. (2010) · The Journal of Neuroscience · doi:10.1523/jneurosci.4987-09.2010 · Cited by 716
Notch Signaling Is Necessary to Maintain Quiescence in Adult Muscle Stem Cells
Bjornson, C. R. R., Cheung, T. H., Liu, L., Tripathi, P. V., Steeper, K. M., & Rando, T. A. (2012) · Stem Cells · doi:10.1002/stem.773 · Cited by 598
Metadata
- Authors
- Kopan, R., & Ilagan, M. X. G.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-04
- Volume
- 137
- Issue
- 2
- Pages
- 216-233
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1997801717
- Cited by
- 3,643
- References
- 8
- FWCI
- 76.94
- Type
- journal article
- Language
- en
- Open access
- bronze
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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