Differentiation of Effector CD4 T Cell Populations

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Control of Regulatory T Cell Development by the Transcription Factor <i>Foxp3</i>

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NF-κB AND REL PROTEINS: Evolutionarily Conserved Mediators of Immune Responses

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The Orphan Nuclear Receptor RORγt Directs the Differentiation Program of Proinflammatory IL-17+ T Helper Cells

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IL-17 and th17 cells

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Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages

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Conversion of Peripheral CD4+CD25− Naive T Cells to CD4+CD25+ Regulatory T Cells by TGF-β Induction of Transcription Factor Foxp3

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A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17

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The Canonical Notch Signaling Pathway: Unfolding the Activation Mechanism

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TGFβ in the Context of an Inflammatory Cytokine Milieu Supports De Novo Differentiation of IL-17-Producing T Cells

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A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

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A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

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The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3

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Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by <i>Listeria</i> -Induced Macrophages

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Transforming growth factor-β induces development of the TH17 lineage

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Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain

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Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12

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Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse

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The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

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IL-6 programs TH-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways

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Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

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X-linked neonatal diabetes mellitus, enteropathy and endocrinopathy syndrome is the human equivalent of mouse scurfy

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Inflammation Directs Memory Precursor and Short-Lived Effector CD8+ T Cell Fates via the Graded Expression of T-bet Transcription Factor

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TGF-β-induced Foxp3 inhibits TH17 cell differentiation by antagonizing RORγt function

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Interleukin-23 Promotes a Distinct CD4 T Cell Activation State Characterized by the Production of Interleukin-17

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IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells

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Requirement of <i>bic/microRNA-155</i> for Normal Immune Function

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piggyBac transposition reprograms fibroblasts to induced pluripotent stem cells

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CD4 T cells: fates, functions, and faults

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Divergent Pro- and Antiinflammatory Roles for IL-23 and IL-12 in Joint Autoimmune Inflammation

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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins

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Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

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Bcl6 and Blimp-1 Are Reciprocal and Antagonistic Regulators of T Follicular Helper Cell Differentiation

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T Helper 17 Lineage Differentiation Is Programmed by Orphan Nuclear Receptors RORα and RORγ

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NFAT proteins: key regulators of T-cell development and function

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Essential role of Stat6 in IL-4 signalling

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Interleukin-2 Signaling via STAT5 Constrains T Helper 17 Cell Generation

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Bcl6 mediates the development of T follicular helper cells

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STAT3 Regulates Cytokine-mediated Generation of Inflammatory Helper T Cells

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Regulation of the Germinal Center Response by MicroRNA-155

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Essential autocrine regulation by IL-21 in the generation of inflammatory T cells

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Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

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INDUCTION OF TH1 AND TH2 CD4+T CELL RESPONSES:The Alternative Approaches

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High-Resolution Mapping and Characterization of Open Chromatin across the Genome

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Dynamic Regulation of Nucleosome Positioning in the Human Genome

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

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Multifunctional TH1 cells define a correlate of vaccine-mediated protection against Leishmania major

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Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene

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Epigenetic Control of the foxp3 Locus in Regulatory T Cells

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The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

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Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin

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IL‐4 directs the development of Th2‐like helper effectors

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The Transcriptional Repressor Bcl-6 Directs T Follicular Helper Cell Lineage Commitment

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STAT3 Mutations in the Hyper-IgE Syndrome

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Transforming growth factor-β 'reprograms' the differentiation of T helper 2 cells and promotes an interleukin 9–producing subset

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Generation of T follicular helper cells is mediated by interleukin-21 but independent of T helper 1, 2, or 17 cell lineages

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Critical Regulation of Early Th17 Cell Differentiation by Interleukin-1 Signaling

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FOXP3 Controls Regulatory T Cell Function through Cooperation with NFAT

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Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells

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Distinct Effects of T-bet in T _H 1 Lineage Commitment and IFN-γ Production in CD4 and CD8 T Cells

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Impaired TH17 cell differentiation in subjects with autosomal dominant hyper-IgE syndrome

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Global Mapping of H3K4me3 and H3K27me3 Reveals Specificity and Plasticity in Lineage Fate Determination of Differentiating CD4+ T Cells

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Cutting Edge: TGF-β Induces a Regulatory Phenotype in CD4+CD25− T Cells through Foxp3 Induction and Down-Regulation of Smad7

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Molecular Antagonism and Plasticity of Regulatory and Inflammatory T Cell Programs

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IL-4 inhibits TGF-β-induced Foxp3+ T cells and, together with TGF-β, generates IL-9+ IL-10+ Foxp3− effector T cells

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MicroRNAs: new regulators of immune cell development and function

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Horror Autoinflammaticus: The Molecular Pathophysiology of Autoinflammatory Disease

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Late Developmental Plasticity in the T Helper 17 Lineage

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T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells

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Control of Effector CD8 ⁺ T Cell Function by the Transcription Factor <i>Eomesodermin</i>

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CD4 ⁺ Regulatory T Cells Control T _H 17 Responses in a Stat3-Dependent Manner

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The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

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Retinoic Acid as a Modulator of T Cell Immunity

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Inflammation negatively regulates FOXP3 and regulatory T-cell function via DBC1

Gao, Y., Tang, J., Chen, W., Li, Q., Nie, J., Lin, F., Wu, Q., Chen, Z., Gao, Z., Fan, H., et al. (2015) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1421463112 · Cited by 140 · see citing works

Hepatic Stellate Cells Function as Regulatory Bystanders

Ichikawa, S., Mucida, D., Tyznik, A. J., Kronenberg, M., & Cheroutre, H. (2011) · The Journal of Immunology · doi:10.4049/jimmunol.1003917 · Cited by 141 · see citing works

The distribution of immunomodulatory cells in the lungs of patients with idiopathic pulmonary fibrosis

Nuovo, G. J., Hagood, J. S., Magro, C. M., Chin, N., Kapil, R., Davis, L., Marsh, C. B., & Folcik, V. A. (2012) · Modern Pathology · doi:10.1038/modpathol.2011.166 · Cited by 123 · see citing works

A review of the mechanisms of action of dimethylfumarate in the treatment of psoriasis

Brück, J., Dringen, R., Amasuno, A., Pau‐Charles, I., & Ghoreschi, K. (2018) · Experimental Dermatology · doi:10.1111/exd.13548 · Cited by 128 · see citing works

Regulation of T-cell activation and migration by the kinase TBK1 during neuroinflammation

Yu, J., Zhou, X., Chang, M., Nakaya, M., Chang, J.-H., Xiao, Y., William Lindsey, J., Dorta-Estremera, S., Cao, W., Zal, A., et al. (2015) · Nature Communications · doi:10.1038/ncomms7074 · Cited by 118 · see citing works

A neuro-immune model of myalgic encephalomyelitis/chronic fatigue syndrome

Morris, G., & Maes, M. (2013) · Metabolic Brain Disease · doi:10.1007/s11011-012-9324-8 · Cited by 117 · see citing works

CD4+ T Lymphocytes, Especially Th2 Cells, Contribute to the Progress of Renal Fibrosis

Liu, L., Kou, P., Zeng, Q., Pei, G., Li, Y., Liang, H., Xu, G., & Chen, S. (2012) · American Journal of Nephrology · doi:10.1159/000343283 · Cited by 111 · see citing works

NAD+ protects against EAE by regulating CD4+ T-cell differentiation

Tullius, S. G., Biefer, H. R. C., Li, S., Trachtenberg, A. J., Edtinger, K., Quante, M., Krenzien, F., Uehara, H., Yang, X., Kissick, H. T., et al. (2014) · Nature Communications · doi:10.1038/ncomms6101 · Cited by 107 · see citing works

Mapping Differentiation under Mixed Culture Conditions Reveals a Tunable Continuum of T Cell Fates

Antebi, Y. E., Reich-Zeliger, S., Hart, Y., Mayo, A., Eizenberg, I., Rimer, J., Putheti, P., Pe'er, D., & Friedman, N. (2013) · PLoS Biology · doi:10.1371/journal.pbio.1001616 · Cited by 100 · see citing works

Neonatal thymectomy reveals differentiation and plasticity within human naive T cells

van den Broek, T., Delemarre, E. M., Janssen, W. J. M., Nievelstein, R. A. J., Broen, J. C., Tesselaar, K., Borghans, J. A. M., Nieuwenhuis, E. E. S., Prakken, B. J., Mokry, M., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci84997 · Cited by 104 · see citing works

Gcn5 Is Required for PU.1-Dependent IL-9 Induction in Th9 Cells

Goswami, R., & Kaplan, M. H. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1201496 · Cited by 97 · see citing works

Regulatory T cells inhibit acute IFN-γ synthesis without blocking T-helper cell type 1 (Th1) differentiation via a compartmentalized requirement for IL-10

Sojka, D. K., & Fowell, D. J. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1110566108 · Cited by 93 · see citing works

Protein phosphatase 2A enables expression of interleukin 17 (IL-17) through chromatin remodeling

Apostolidis, S. A., Rauen, T., Hedrich, C. M., Tsokos, G. C., & Crispín, J. C. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m113.483743 · Cited by 91 · see citing works

Blocking integrin α4β7-mediated CD4 T cell recruitment to the intestine and liver protects mice from western diet-induced non-alcoholic steatohepatitis

Rai, R. P., Liu, Y., Iyer, S. S., Liu, S., Gupta, B., Desai, C., Kumar, P., Smith, T., Singhi, A. D., Nusrat, A., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.05.047 · Cited by 86 · see citing works

Non-cell autonomous effects of the senescence-associated secretory phenotype in cancer therapy.

Saleh, T., Tyutynuk-Massey, L., Cudjoe, E. K., Idowu, M. O., Landry, J. W., & Gewirtz, D. A. (2018) · Frontiers in Oncology · doi:10.3389/fonc.2018.00164 · Cited by 85 · see citing works

Integrative molecular profiling of autoreactive CD4 T cells in autoimmune hepatitis

Renand, A., Cervera-Marzal, I., Gil, L., Dong, C., Garcia, A., Kervagoret, E., Aublé, H., Habes, S., Chevalier, C., Vavasseur, F., et al. (2020) · Journal of Hepatology · doi:10.1016/j.jhep.2020.05.053 · Cited by 80 · see citing works

Host-microbiota interactions and adaptive immunity

McCoy, K. D., Ronchi, F., & Geuking, M. B. (2017) · Immunological Reviews · doi:10.1111/imr.12575 · Cited by 77 · see citing works

New and Emerging Targeted Therapies for Hidradenitis Suppurativa

Markota Čagalj, A., Marinović, B., & Bukvić Mokos, Z. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23073753 · Cited by 74 · see citing works

Effective anti-neu-initiated antitumor responses require the complex role of CD4+ T cells

Mortenson, E. D., Park, S., Jiang, Z., Wang, S., & Fu, Y.-X. (2013) · Clinical Cancer Research · doi:10.1158/1078-0432.ccr-12-2522 · Cited by 66 · see citing works

Single-cell transcriptome landscape of circulating CD4+ T cell populations in autoimmune diseases

Yasumizu, Y., Takeuchi, D., Morimoto, R., Takeshima, Y., Okuno, T., Kinoshita, M., Morita, T., Kato, Y., Wang, M., Motooka, D., et al. (2024) · Cell Genomics · doi:10.1016/j.xgen.2023.100473 · Cited by 60 · see citing works

Therapeutic Cancer Vaccines—T Cell Responses and Epigenetic Modulation

Kartikasari, A. E. R., Prakash, M. D., Cox, M., Wilson, K., Boer, J. C., Cauchi, J. A., & Plebanski, M. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2018.03109 · Cited by 54 · see citing works

TLR2 Stimulation Strengthens Intrahepatic Myeloid-Derived Cell-Mediated T Cell Tolerance through Inducing Kupffer Cell Expansion and IL-10 Production

Liu, J., Yu, Q., Wu, W., Huang, X., Broering, R., Werner, M., Roggendorf, M., Yang, D., & Lu, M. (2018) · The Journal of Immunology · doi:10.4049/jimmunol.1700540 · Cited by 50 · see citing works

Ectopic lymphoid follicles in progressive multiple sclerosis: From patients to animal models

Zhan, J., Kipp, M., Han, W., & Kaddatz, H. (2021) · Immunology · doi:10.1111/imm.13395 · Cited by 49 · see citing works

NAD+ regulates Treg cell fate and promotes allograft survival via a systemic IL-10 production that is CD4+ CD25+ Foxp3+ T cells independent

Elkhal, A., Rodriguez Cetina Biefer, H., Heinbokel, T., Uehara, H., Quante, M., Seyda, M., Schuitenmaker, J. M., Krenzien, F., Camacho, V., de la Fuente, M. A., et al. (2016) · Scientific Reports · doi:10.1038/srep22325 · Cited by 46 · see citing works

Foxo transcription factors in T cell biology and tumor immunity

Luo, C. T., & Li, M. O. (2018) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2018.04.006 · Cited by 46 · see citing works

Circulating c-Met–Expressing Memory T Cells Define Cardiac Autoimmunity

Fanti, S., Stephenson, E., Rocha-Vieira, E., Protonotarios, A., Kanoni, S., Shahaj, E., Longhi, M. P., Vyas, V. S., Dyer, C., Pontarini, E., et al. (2022) · Circulation · doi:10.1161/circulationaha.121.055610 · Cited by 44 · see citing works

Male sex chromosomal complement exacerbates the pathogenicity of Th17 cells in a chronic model of central nervous system autoimmunity

Doss, P. M. I. A., Umair, M., Baillargeon, J., Fazazi, R., Fudge, N., Akbar, I., Yeola, A. P., Williams, J. B., Leclercq, M., Joly-Beauparlant, C., et al. (2021) · Cell Reports · doi:10.1016/j.celrep.2021.108833 · Cited by 39 · see citing works

Understanding asthma and allergies by the lens of biodiversity and epigenetic changes

Fiuza, B. S. D., Fonseca, H. F., Meirelles, P. M., Marques, C. R., da Silva, T. M., & Figueiredo, C. A. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2021.623737 · Cited by 38 · see citing works

Heat Shock Protein 90 Family Isoforms as Prognostic Biomarkers and Their Correlations with Immune Infiltration in Breast Cancer

Lin, T., Qiu, Y., Peng, W., & Peng, L. (2020) · BioMed Research International · doi:10.1155/2020/2148253 · Cited by 31 · see citing works

Sulphated polysaccharide from the sea cucumber Cucumaria frondosa affect maturation of human dendritic cells and their activation of allogeneic CD4(+) T cells in vitro

Kale, V., Freysdottir, J., Paulsen, B. S., Friðjónsson, Ó. H., Óli Hreggviðsson, G., & Omarsdottir, S. (2013) · Bioactive Carbohydrates and Dietary Fibre · doi:10.1016/j.bcdf.2013.09.009 · Cited by 29 · see citing works

Schistosome infection promotes osteoclast-mediated bone loss

Li, W., Wei, C., Xu, L., Yu, B., Chen, Y., Lu, D., Zhang, L., Song, X., Dong, L., Zhou, S., et al. (2021) · PLoS Pathogens · doi:10.1371/journal.ppat.1009462 · Cited by 22 · see citing works

A novel Toxoplasma gondii TGGT1_316290 mRNA-LNP vaccine elicits protective immune response against toxoplasmosis in mice

Li, D., Zhang, Y., Li, S., & Zheng, B. (2023) · Frontiers in Microbiology · doi:10.3389/fmicb.2023.1145114 · Cited by 22 · see citing works

An organolutetium nanosensitizer synergizes with PARP inhibition to unleash STING-mediated immunity for low-dose radioimmunotherapy

Zeng, B., Ling, K., Yuan, Q., Chen, Z., Zhang, G., Kang, W., Zheng, X., Liao, C., Mai, Y., Huang, Z., et al. (2026) · Theranostics · doi:10.7150/thno.124034 · Cited by 7 · see citing works