The DOI matches its Crossref record; 4 of the 4 references it cites were found in a registry or an index.
A Class of Dynamin-like GTPases Involved in the Generation of the Tubular ER Network
Open accessAbstract
The endoplasmic reticulum (ER) consists of tubules that are shaped by the reticulons and DP1/Yop1p, but how the tubules form an interconnected network is unknown. Here, we show that mammalian atlastins, which are dynamin-like, integral membrane GTPases, interact with the tubule-shaping proteins. The atlastins localize to the tubular ER and are required for proper network formation in vivo and in vitro. Depletion of the atlastins or overexpression of dominant-negative forms inhibits tubule interconnections. The Sey1p GTPase in S. cerevisiae is likely a functional ortholog of the atlastins; it shares the same signature motifs and membrane topology and interacts genetically and physically with the tubule-shaping proteins. Cells simultaneously lacking Sey1p and a tubule-shaping protein have ER morphology defects. These results indicate that formation of the tubular ER network depends on conserved dynamin-like GTPases. Since atlastin-1 mutations cause a common form of hereditary spastic paraplegia, we suggest ER shaping defects as a novel neuropathogenic mechanism.
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Cites
Global analysis of protein expression in yeast
Ghaemmaghami, S., Huh, W.-K., Bower, K., Howson, R. W., Belle, A., Dephoure, N., O'Shea, E. K., & Weissman, J. S. (2003) · Nature · doi:10.1038/nature02046 · Cited by 3,750
Chen, H., Detmer, S. A., Ewald, A. J., Griffin, E. E., Fraser, S. E., & Chan, D. C. (2003) · The Journal of Cell Biology · doi:10.1083/jcb.200211046 · Cited by 2,601
Schuldiner, M., Collins, S. R., Thompson, N. J., Denic, V., Bhamidipati, A., Punna, T., Ihmels, J., Andrews, B., Boone, C., Greenblatt, J. F., et al. (2005) · Cell · doi:10.1016/j.cell.2005.08.031 · Cited by 870 · cited 1×
“A large-scale screen for genetic interaction partners also demonstrated synthetic effects of yop1 and sey1 deletions (Schuldiner et al., 2005).”
BackgroundThe Machines that Divide and Fuse Mitochondria
Hoppins, S., Lackner, L., & Nunnari, J. (2007) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.76.071905.090048 · Cited by 790
Cited by
The endoplasmic reticulum: structure, function and response to cellular signaling
Schwarz, D. S., & Blower, M. D. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-015-2052-6 · Cited by 1,613
Harbour, M. E., Breusegem, S. Y. A., Antrobus, R., Freeman, C., Reid, E., & Seaman, M. N. J. (2010) · Journal of Cell Science · doi:10.1242/jcs.071472 · Cited by 246
Rab10 GTPase regulates ER dynamics and morphology
English, A. R., & Voeltz, G. K. (2013) · Nature Cell Biology · doi:10.1038/ncb2647 · Cited by 224
Montenegro, G., Rebelo, A. P., Connell, J., Allison, R., Babalini, C., D’Aloia, M., Montieri, P., Schüle, R., Ishiura, H., Price, J., et al. (2012) · Journal of Clinical Investigation · doi:10.1172/jci60560 · Cited by 170
Guelly, C., Zhu, P.-P., Leonardis, L., Papić, L., Zidar, J., Schabhüttl, M., Strohmaier, H., Weis, J., Strom, T. M., Baets, J., et al. (2011) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.12.003 · Cited by 143
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Metadata
- Authors
- Hu, J., Shibata, Y., Zhu, P.-P., Voss, C., Rismanchi, N., Prinz, W. A., Rapoport, T. A., & Blackstone, C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-08
- Volume
- 138
- Issue
- 3
- Pages
- 549-561
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2165615730
- Cited by
- 538
- References
- 4
- FWCI
- 13.77
- Type
- journal article
- Language
- en
- Open access
- bronze
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