The DOI matches its Crossref record; 54 of the 54 references it cites were found in a registry or an index.
The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior
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SUMMARY The amygdala processes and directs inputs and outputs that are key to fear behavior. However, whether it directly senses fear-evoking stimuli is unknown. Because the amygdala expresses acid sensing ion channel-1a (ASIC1a), and ASIC1a is required for normal fear responses, we hypothesized that the amygdala might detect a reduced pH. We found that inhaled CO2 reduced brain pH and evoked fear behavior in mice. Eliminating or inhibiting ASIC1a markedly impaired this activity, and localized ASIC1a expression in the amygdala rescued the CO2- induced fear deficit of ASIC1a-null animals. Buffering pH attenuated fear behavior, whereas directly reducing pH with amygdala microinjections reproduced the effect of CO2. These data identify the amygdala as an important chemosensor that detects hypercarbia and acidosis and initiates behavioral responses. They also give a molecular explanation for how rising CO2 concentrations elicit intense fear and provide a foundation for dissecting the bases of anxiety and panic disorders.
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Cites
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The cells and logic for mammalian sour taste detection
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Cited by
Lactate in the brain: from metabolic end-product to signalling molecule
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Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala
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Fear and panic in humans with bilateral amygdala damage
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Metadata
- Authors
- Ziemann, A. E., Allen, J. E., Dahdaleh, N. S., Drebot, I. I., Coryell, M. W., Wunsch, A. M., Lynch, C. M., Faraci, F. M., Howard, M. A., Welsh, M. J., & Wemmie, J. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2009-11
- Volume
- 139
- Issue
- 5
- Pages
- 1012-1021
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2014671181
- Cited by
- 434
- References
- 54
- FWCI
- 11.86
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Ziemann, A. E., Allen, J. E., Dahdaleh, N. S., Drebot, I. I., Coryell, M. W., Wunsch, A. M., Lynch, C. M., Faraci, F. M., Howard, M. A., Welsh, M. J., & Wemmie, J. A. (2009). The Amygdala Is a Chemosensor that Detects Carbon Dioxide and Acidosis to Elicit Fear Behavior. Cell. https://doi.org/10.1016/j.cell.2009.10.029
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