Oxytocin Selectively Gates Fear Responses Through Distinct Outputs from the Central Amygdala
Abstract
Specific neuronal populations in the amygdala control different behavioral and physiological components of the fear response.
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Within the rodent central amygdala, oxytocin receptor density differs across subdivisions.
“OT receptor density varies by subdivision within the central nucleus of the rodent amygdala (CeA)4,6”
From Oxytocin increases anxiety to unpredictable threat (2013) · cites this paper as [4]
In animals, oxytocin can lessen anxiety-like behavior through its modulatory action on the amygdala.
“Indeed, OT can reduce anxiety-like behavior in animals, via its neuromodulatory influence on the amygdala, a core hub mediating fear and anxiety.4”
From Oxytocin increases anxiety to unpredictable threat (2013) · cites this paper as [4]
The implication of CeA OXT signaling in processing threat responses and social fear suggests a specific role in detection of fear-mediated responses.
“The implication of CeA OXT signaling in processing threat responses [22,94,104] and social fear [105] would suggest a specific role in the detection of fear-mediated responses.”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [104]
Distinct neuronal populations in sub-regions of the amygdala control specific behavioral responses to fear.
“Distinct neuronal populations in sub-regions of the amygdala have indeed been shown to control specific behavioral responses to fear [104, 108]”
From Oxytocin Signaling in the Central Amygdala Modulates Emotion Discrimination in Mice (2019) · cites this paper as [104]
Previous studies have shown that oxytocin receptors in the amygdala potentiate GABAergic inhibition.
“Previous studies have shown that OXT receptors in the amygdala potentiate GABAergic inhibition (ie, Huber et al, 2005;Viviani et al, 2011).”
From Modulation of Resting-State Amygdala-Frontal Functional Connectivity by Oxytocin in Generalized Social Anxiety Disorder (2014) · cites this paper as Viviani et al, 2011
Prior studies have suggested that oxytocin is anxiolytic or attenuates measures of fear conditioning.
“The results of a number of other studies have suggested that oxytocin is anxiolytic19–21 or attenuates measures of fear conditioning15–18.”
From Oxytocin enhances observational fear in mice (2017) · cites this paper as [15]
OT modulates emotional behavioral responses and attention to social cues by altering activity of reward neural circuitry, perceptual network, and fear-stress circuitry.
“These results highlight OT’s role in modulating emotional behavioral responses and attention to social cues by altering the activity of reward neural circuitry, perceptual network, and the fear-stress circuitry (Knobloch et al. 2012; Knobloch and Grinevich 2014; Viviani et al. 2011).”
From A precision medicine approach to oxytocin trials (2017) · cites this paper as Viviani et al. 2011
In rats, oxytocinergic neurons regulate autonomic fear responses through a specialized circuit via the central amygdala.
“For mediating fear-related responses, it has been verified in rats that oxytocinergic neurons regulate autonomic fear responses through a specialized circuit via the central amygdala (Huber, 2005; Viviani et al., 2011).”
From Oxytocin and social cognition in rhesus macaques: Implications for understanding and treating human psychopathology (2014) · cites this paper as Viviani et al., 2011
Inhibition of PKCδ-positive CeLOFF cells by PKCδ-negative CeLON cells results in disinhibition of CeM output neurons, consequently driving freezing behavior and changes in heart rate via CeM projections to the periaqueductal gray and dorsal vagal complex.
“Inhibition of the latter population by the former results in the disinhibition of CeM output neurons, consequently driving freezing behavior and changes in heart rate via CeM projections to the periaqueductal gray and dorsal vagal complex, respectively52 (Fig. 3).”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [52]
Changes in heart rate, respiration and glucocorticoid levels require the activation of distinct pathways from those that drive anxiety-like behaviors.
“Moreover, a thorough understanding of the neural circuits underlying anxiety must include a consideration of its somatic symptoms, as changes in heart rate, respiration and glucocorticoid levels require the activation of distinct pathways from those that drive anxiety-like behaviors31,52.”
From Resolving the neural circuits of anxiety (2015) · cites this paper as [52]
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- Authors
- Viviani, D., Charlet, A., van den Burg, E., Robinet, C., Hurni, N., Abatis, M., Magara, F., & Stoop, R.
- Affiliations
- Centre Hospitalier Universitaire Vaudois (CH)
- Centre for Psychiatric Neuroscience, Department of Psychiatry, Lausanne University Hospital Center, University of Lausanne, CH-1015 Lausanne, Switzerland.
- Corresponding author
- Robinet, Camille
- Stoop, Ron
- Venue
- Science
- Published
- 2011-07
- Volume
- 333
- Issue
- 6038
- Pages
- 104-107
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2091857612
- Cited by
- 381
- References
- 28
- Citations by year
- 2026: 13 · 2025: 9 · 2024: 22 · 2023: 13 · 2022: 19 · 2021: 29 · 2020: 32 · 2019: 18 · 2018: 33 · 2017: 33 · 2016: 28 · 2015: 34 · 2014: 39 · 2013: 27 · 2012: 26
- FWCI
- 41.72
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Science (publishedVersion)
- PubMed (publishedVersion)
- HAL (submittedVersion)
- IRIS (submittedVersion)
- SERVAL (Université de Lausanne) (submittedVersion)
- Topics
- Social Sciences › Psychology › Social Psychology › Neuroendocrine regulation and behavior
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, central amygdala, fear response, freezing behavior, cardiovascular response, hypothalamic projections, neuronal subpopulations, fear conditioning, neural circuits
- MeSH terms
- Amygdala, Animals, Bombesin, Brain Stem, Conditioning, Psychological, Fear, Female, Heart Rate, Hypothalamus, Male, Muscimol, Neural Inhibition, Neural Pathways, Neurons, Oxytocin, Periaqueductal Gray, Rats, Sprague-Dawley, Patch-Clamp Techniques, Rats, GABA-A Receptor Agonists
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