The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions
Open accessAbstract
Summary The incorporation of histone H3 variants has been implicated in the epigenetic memory of cellular state. Using genome editing with zinc finger nucleases to tag endogenous H3.3, we report genome-wide profiles of H3 variants in mammalian embryonic stem (ES) cells and neuronal precursor cells. Genome-wide patterns of H3.3 are dependent on amino acid sequence, and change with cellular differentiation at developmentally regulated loci. The H3.3 chaperone Hira is required for H3.3 enrichment at active and repressed genes. Strikingly, Hira is not essential for localization of H3.3 at telomeres and many transcription factor binding sites. Immunoaffinity purification and mass spectrometry reveal that the proteins Atrx and Daxx associate with H3.3 in a Hira-independent manner. Atrx is required for Hira-independent localization of H3.3 at telomeres, and for the repression of telomeric RNA. Our data demonstrate that multiple and distinct factors are responsible for H3.3 localization at specific genomic locations in mammalian cells.
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Cites
High-Resolution Profiling of Histone Methylations in the Human Genome
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A bivalent chromatin structure marks key developmental genes in embryonic stem cells
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“3 have been separately shown to significantly colocalize with TFBS and other regulatory elements (Heintzman et al., 2007; Mito et al., 2007; Wang et al., 2008), but the patterns of H3.”
BackgroundCombinatorial patterns of histone acetylations and methylations in the human genome
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An improved zinc-finger nuclease architecture for highly specific genome editing
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Self-citationStem cell transcriptome profiling via massive-scale mRNA sequencing
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Mammalian Telomeres Resemble Fragile Sites and Require TRF1 for Efficient Replication
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Cited by
Driver mutations in histone H3.3 and chromatin remodelling genes in paediatric glioblastoma
Schwartzentruber, J., Korshunov, A., Liu, X.-Y., Jones, D. T. W., Pfaff, E., Jacob, K., Sturm, D., Fontebasso, A. M., Quang, D.-A. K., Tönjes, M., et al. (2012) · Nature · doi:10.1038/nature10833 · Cited by 2,631
Genome editing with engineered zinc finger nucleases
Urnov, F. D., Rebar, E. J., Holmes, M. C., Zhang, H. S., & Gregory, P. D. (2010) · Nature Reviews Genetics · doi:10.1038/nrg2842 · Cited by 2,285
Self-citationHistone methylation: a dynamic mark in health, disease and inheritance
Greer, E. L., & Shi, Y. (2012) · Nature Reviews Genetics · doi:10.1038/nrg3173 · Cited by 2,241
Sturm, D., Witt, H., Hovestadt, V., Khuong-Quang, D.-A., Jones, D. T. W., Konermann, C., Pfaff, E., Tönjes, M., Sill, M., Bender, S., et al. (2012) · Cancer Cell · doi:10.1016/j.ccr.2012.08.024 · Cited by 1,828
St. Jude Children's Research Hospital–Washington University Pediatric Cancer Genome Project (2012) · Nature Genetics · doi:10.1038/ng.1102 · Cited by 1,724
Metadata
- Authors
- Goldberg, A. D., Banaszynski, L. A., Noh, K.-M., Lewis, P. W., Elsaesser, S. J., Stadler, S., Dewell, S., Law, M., Guo, X., Li, X., Wen, D., Chapgier, A., DeKelver, R. C., Miller, J. C., Lee, Y.-L., Boydston, E. A., Holmes, M. C., Gregory, P. D., Greally, J. M., Rafii, S., Yang, C., Scambler, P. J., Garrick, D., Gibbons, R. J., Higgs, D. R., Cristea, I. M., Urnov, F. D., Zheng, D., & Allis, C. D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-03
- Volume
- 140
- Issue
- 5
- Pages
- 678-691
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1970916644
- Cited by
- 1,280
- References
- 13
- FWCI
- 37.69
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Goldberg, A. D., Banaszynski, L. A., Noh, K.-M., Lewis, P. W., Elsaesser, S. J., Stadler, S., Dewell, S., Law, M., Guo, X., Li, X., Wen, D., Chapgier, A., DeKelver, R. C., Miller, J. C., Lee, Y.-L., Boydston, E. A., Holmes, M. C., Gregory, P. D., Greally, J. M., . . . Allis, C. D. (2010). Distinct Factors Control Histone Variant H3.3 Localization at Specific Genomic Regions. Cell. https://doi.org/10.1016/j.cell.2010.01.003
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