Genome editing with engineered zinc finger nucleases

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Efficient targeting of expressed and silent genes in human ESCs and iPSCs using zinc-finger nucleases

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Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

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Precise genome modification in the crop species Zea mays using zinc-finger nucleases

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Knockout Rats via Embryo Microinjection of Zinc-Finger Nucleases

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Mitotic homologous recombination maintains genomic stability and suppresses tumorigenesis

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Heritable targeted gene disruption in zebrafish using designed zinc-finger nucleases

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Targeted Chromosomal Cleavage and Mutagenesis in Drosophila Using Zinc-Finger Nucleases

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Gene editing in human stem cells using zinc finger nucleases and integrase-defective lentiviral vector delivery

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Enhancing Gene Targeting with Designed Zinc Finger Nucleases

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Chimeric nucleases stimulate gene targeting in human cells

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Targeted gene inactivation in zebrafish using engineered zinc-finger nucleases

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High-frequency modification of plant genes using engineered zinc-finger nucleases

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Rapid “Open-Source” Engineering of Customized Zinc-Finger Nucleases for Highly Efficient Gene Modification

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Human hematopoietic stem/progenitor cells modified by zinc-finger nucleases targeted to CCR5 control HIV-1 in vivo

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Crystal Structure of a Five-Finger GLI-DNA Complex: New Perspectives on Zinc Fingers

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High frequency targeting of genes to specific sites in the mammalian genome

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Stimulation of Homologous Recombination through Targeted Cleavage by Chimeric Nucleases

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Gene Targeting of a Disease-Related Gene in Human Induced Pluripotent Stem and Embryonic Stem Cells

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Structure-based redesign of the dimerization interface reduces the toxicity of zinc-finger nucleases

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Targeted genome editing in human cells with zinc finger nucleases constructed via modular assembly

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Unexpected failure rates for modular assembly of engineered zinc fingers

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Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences

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Targeted mutagenesis using zinc-finger nucleases in Arabidopsis

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High frequency targeted mutagenesis in Arabidopsis thaliana using zinc finger nucleases

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Targeted gene addition into a specified location in the human genome using designed zinc finger nucleases

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Targeted gene knockout in mammalian cells by using engineered zinc-finger nucleases

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The crystal structure of a two zinc-finger peptide reveals an extension to the rules for zinc-finger/DNA recognition

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A General Strategy for Selecting High-Affinity Zinc Finger Proteins for Diverse DNA Target Sites

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Development of Zinc Finger Domains for Recognition of the 5′-ANN-3′ Family of DNA Sequences and Their Use in the Construction of Artificial Transcription Factors

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Toward a code for the interactions of zinc fingers with DNA: selection of randomized fingers displayed on phage.

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Zinc Finger Tools: custom DNA-binding domains for transcription factors and nucleases

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Functional genomics, proteomics, and regulatory DNA analysis in isogenic settings using zinc finger nuclease-driven transgenesis into a safe harbor locus in the human genomePreprint

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Site-directed mutagenesis in Arabidopsis using custom-designed zinc finger nucleases

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Homologous recombination in plant cells is enhanced by in vivo induction of double strand breaks into DNA by a site-specific endonuclease

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Efficient gene targeting in Drosophila by direct embryo injection with zinc-finger nucleases

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Targeted chromosomal deletions in human cells using zinc finger nucleasesPreprint

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Rapid Mutation of Endogenous Zebrafish Genes Using Zinc Finger Nucleases Made by Oligomerized Pool ENgineering (OPEN)

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Differing roles for zinc fingers in DNA recognition: Structure of a six-finger transcription factor IIIA complex

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Generation of Knockout Rats with X-Linked Severe Combined Immunodeficiency (X-SCID) Using Zinc-Finger Nucleases

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Efficient Gene Targeting in Drosophila With Zinc-Finger Nucleases

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Progress and prospects: Zinc-finger nucleases as gene therapy agents

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Targeted transgene integration in plant cells using designed zinc finger nucleases

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In vitro selection of zinc fingers with altered DNA-binding specificity

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Zinc-finger nuclease-driven targeted integration into mammalian genomes using donors with limited chromosomal homology

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Chromosomal translocations induced at specified loci in human stem cells

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Directed evolution of an enhanced and highly efficient FokI cleavage domain for zinc finger nucleases

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Human zinc fingers as building blocks in the construction of artificial transcription factors

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Cocrystal structure of YY1 bound to the adeno-associated virus P5 initiator

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A rapid, generally applicable method to engineer zinc fingers illustrated by targeting the HIV-1 promoter

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FokI requires two specific DNA sites for cleavage

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Evaluation of a Modular Strategy for the Construction of Novel Polydactyl Zinc Finger DNA-Binding Proteins

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Role of the Aggresome Pathway in Cancer: Targeting Histone Deacetylase 6–Dependent Protein Degradation

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Development of Zinc Finger Domains for Recognition of the 5′-CNN-3′ Family DNA Sequences and Their Use in the Construction of Artificial Transcription Factors

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Facile methods for generating human somatic cell gene knockouts using recombinant adeno-associated viruses

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Highly efficient deletion of <i>FUT8</i> in CHO cell lines using zinc‐finger nucleases yields cells that produce completely nonfucosylated antibodies

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Improved DNA binding specificity from polyzinc finger peptides by using strings of two-finger units

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BAK and BAX deletion using zinc‐finger nucleases yields apoptosis‐resistant CHO cells

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Highly specific zinc finger proteins obtained by directed domain shuffling and cell-based selection

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Identification of chromosome sequence motifs that mediate meiotic pairing and synapsis in C. elegans

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Expanding or Restricting the Target Site Repertoire of Zinc-finger Nucleases: The Inter-domain Linker as a Major Determinant of Target Site Selectivity

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Transient cold shock enhances zinc-finger nuclease–mediated gene disruption

Doyon, Y., Choi, V. M., Xia, D. F., Vo, T. D., Gregory, P. D., & Holmes, M. C. (2010) · Nature Methods · doi:10.1038/nmeth.1456 · Cited by 137 · see citing works

Zinc finger nuclease-mediated transgene deletion

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Engineering of human pluripotent stem cells by AAV-mediated gene targeting.

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Plant genome modification by homologous recombination

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Chemokine signaling guides regional patterning of the first embryonic arteryPreprint

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The Catalytic Subunit of DNA-Dependent Protein Kinase Regulates Proliferation, Telomere Length, and Genomic Stability in Human Somatic Cells

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Beyond the “Recognition Code”

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Genetic Analysis of Zinc-Finger Nuclease-Induced Gene Targeting in Drosophila

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Generation of a triple-gene knockout mammalian cell line using engineered zinc-finger nucleases

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Regulation of the MDR1 Gene by Transcriptional Repressors Selected Using Peptide Combinatorial Libraries

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Structure of Aart, a Designed Six-finger Zinc Finger Peptide, Bound to DNA

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A pro-resolution mediator, prostaglandin D 2 , is specifically up-regulated in individuals in long-term remission from ulcerative colitis

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