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A Global In Vivo Drosophila RNAi Screen Identifies NOT3 as a Conserved Regulator of Heart Function
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This hit rate is well above the reported hit rate (10%) of a genome-wide cardiac RNAi screen and comparable to the 53% of a targeted approach based on sequence information of CHD patients.
“This is well above the reported hit rate (10%) of a genome-wide cardiac RNAi screen [43] and is comparable to the 53% of a targeted approach based on sequence information of CHD patients [42].”
From A cis-regulatory-directed pipeline for the identification of genes involved in cardiac development and disease (2021) · cites this paper as [43]
The Results report that approximately 10% of 80 randomly selected RNAi lines in a prescreen began to die at increased temperature. The paper did conduct a genome-wide cardiac RNAi screen, but the cited 10% figure describes the prescreen, not a reported hit rate for the genome-wide screen. The 53% figure is attributed to a different citation and is not assessed here. (LLM, conf=0.88)
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Estimation of significance thresholds for genomewide association scans
Dudbridge, F., & Gusnanto, A. (2008) · Genetic Epidemiology · doi:10.1002/gepi.20297 · Cited by 703
Nabel, E. G. (2003) · New England Journal of Medicine · doi:10.1056/nejmra035098 · Cited by 431
Studying cardiac arrhythmias in the mouse—a reasonable model for probing mechanisms?
Nerbonne, J. (2004) · Trends in Cardiovascular Medicine · doi:10.1016/j.tcm.2003.12.006 · Cited by 175
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Metadata
- Authors
- Neely, G. G., Kuba, K., Cammarato, A., Isobe, K., Amann, S., Zhang, L., Murata, M., Elmén, L., Gupta, V., Arora, S., Sarangi, R., Dan, D., Fujisawa, S., Usami, T., Xia, C.-P., Keene, A. C., Alayari, N. N., Yamakawa, H., Elling, U., Berger, C., Novatchkova, M., Koglgruber, R., Fukuda, K., Nishina, H., Isobe, M., Pospisilik, J. A., Imai, Y., Pfeufer, A., Hicks, A. A., Pramstaller, P. P., Subramaniam, S., Kimura, A., Ocorr, K., Bodmer, R., & Penninger, J. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-04
- Volume
- 141
- Issue
- 1
- Pages
- 142-153
- ISSN
- 0092-8674
- Cited by
- 213
- References
- 4
- Language
- en
- Licence
- www.elsevier.com/tdm/userlicense/1.0/ (tdm)
- www.elsevier.com/legal/tdmrep-license (tdm)
- www.elsevier.com/open-access/userlicense/1.0/ (vor, 1239 d)
- doi.org/10.15223/policy-017 (stm-asf)
- doi.org/10.15223/policy-037 (stm-asf)
- doi.org/10.15223/policy-012 (stm-asf)
- doi.org/10.15223/policy-029 (stm-asf)
- doi.org/10.15223/policy-004 (stm-asf)
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