SRD5A3: a surprising role in glycosylation
Open accessAbstract
The steroid 5alpha-reductase (SRD5A) family of enzymes produces steroid hormones that regulate male sexual development. Now, Cantagrel et al. (2010) identify a member of this family, SRD5A3, as a polyprenol reductase with a crucial role in N-linked protein glycosylation and pinpoint SRD5A3 mutations as the cause of a rare Mendelian disease.
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SRD5A3 plays an important role in N-linked protein glycosylation.
“has been shown to play an important role in N-linked protein glycosylation [[96], [97], [98]]”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [97]
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Cites
Steroid 5α-reductase: two genes/two enzymes
Russell, D. W., & Wilson, J. D. (1994) · Annual Review of Biochemistry · doi:10.1146/annurev.bi.63.070194.000325 · Cited by 1,105 · see citing works
Self-citationCantagrel, V., Lefeber, D. J., Ng, B. G., Guan, Z., Silhavy, J. L., Bielas, S. L., Lehle, L., Hombauer, H., Adamowicz, M., Swiezewska, E., et al. (2010) · Cell · doi:10.1016/j.cell.2010.06.001 · Cited by 309 · see citing works
Novel 5α‐steroid reductase (SRD5A3, type‐3) is overexpressed in hormone‐refractory prostate cancer
Uemura, M., Tamura, K., Chung, S., Honma, S., Okuyama, A., Nakamura, Y., & Nakagawa, H. (2008) · Cancer Science · doi:10.1111/j.1349-7006.2007.00656.x · Cited by 263 · see citing works
Identification of Two Mammalian Reductases Involved in the Two-carbon Fatty Acyl Elongation Cascade
Moon, Y.-A., & Horton, J. D. (2003) · Journal of Biological Chemistry · doi:10.1074/jbc.m211684200 · Cited by 214 · see citing works
Conservation of function between mammalian and plant steroid 5α-reductases
Li, J., Biswas, M. G., Chao, A., Russell, D. W., & Chory, J. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.8.3554 · Cited by 167 · see citing works
Self-citationWilson, J. D. (1978) · Annual Review of Physiology · doi:10.1146/annurev.ph.40.030178.001431 · Cited by 162 · see citing works
Evolution of steroid-5α-reductases and comparison of their function with 5β-reductase
Langlois, V. S., Zhang, D., Cooke, G. M., & Trudeau, V. L. (2009) · General and Comparative Endocrinology · doi:10.1016/j.ygcen.2009.08.004 · Cited by 90 · see citing works
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Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works
Understanding Human Glycosylation Disorders: Biochemistry Leads the Charge
Freeze, H. H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.r112.429274 · Cited by 213 · see citing works
Reduced Bone Mass and Muscle Strength in Male 5α-Reductase Type 1 Inactivated Mice
Windahl, S. H., Andersson, N., Börjesson, A. E., Swanson, C., Svensson, J., Movérare-Skrtic, S., Sjögren, K., Shao, R., Lagerquist, M. K., & Ohlsson, C. (2011) · PLoS ONE · doi:10.1371/journal.pone.0021402 · Cited by 56 · see citing works
“However, others claim that 5a-reductase type 3 has little or no functional ability to reduce steroid substrates but rather has a crucial role in N-linked protein glycosylation [21,24].”
Background5α-Reductases in human physiology: an unfolding story
Traish, A. M. (2012) · Endocrine Practice · doi:10.4158/ep12108.ra · Cited by 57 · see citing works
- Authors
- Stiles, A. R., & Russell, D. W.
- Affiliations
- The University of Texas Southwestern Medical Center (US)
- Corresponding author
- Russell, David W.
- ORCID
- Russell, David W.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-07
- Volume
- 142
- Issue
- 2
- Pages
- 196-198
- ISSN
- 0092-8674 (ISSN-L)
- PMC
- PMC3104503
- OpenAlex
- W1994052047
- Cited by
- 66
- References
- 7
- Citations by year
- 2026: 4 · 2025: 2 · 2024: 8 · 2023: 3 · 2022: 4 · 2021: 7 · 2020: 5 · 2019: 5 · 2018: 3 · 2017: 2 · 2016: 6 · 2015: 4 · 2014: 4 · 2013: 3 · 2012: 3
- FWCI
- 1.04
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Licence
- Locations
- Cell (publishedVersion)
- PubMed (publishedVersion)
- PubMed Central (acceptedVersion)
- Funders
- National Institute of General Medical Sciences (T32GM083831)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Glycosylation and Glycoproteins Research
- Health Sciences › Medicine › Physiology › Lysosomal Storage Disorders Research
- Health Sciences › Medicine › Rheumatology › Glycogen Storage Diseases and Myoclonus
- Keywords
- SRD5A3, 5α-reductase, N-glycosylation, steroidogenesis, male reproductive development, monogenic disorders
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