The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.
Pluripotency and Cellular Reprogramming: Facts, Hypotheses, Unresolved Issues
Open accessAbstract
Direct reprogramming of somatic cells to induced pluripotent stem cells by ectopic expression of defined transcription factors has raised fundamental questions regarding the epigenetic stability of the differentiated cell state. In addition, evidence has accumulated that distinct states of pluripotency can inter-convert through the modulation of both cell-intrinsic and exogenous factors. To fully realize the potential of in vitro reprogrammed cells, we need to understand the molecular and epigenetic determinants that convert one cell type into another. Here we review recent advances in this rapidly moving field and emphasize unresolved and controversial questions.
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Cites
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Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells
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The ground state of embryonic stem cell self-renewal
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Direct conversion of fibroblasts to functional neurons by defined factors
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Genome-scale DNA methylation maps of pluripotent and differentiated cells
Meissner, A., Mikkelsen, T. S., Gu, H., Wernig, M., Hanna, J., Sivachenko, A., Zhang, X., Bernstein, B. E., Nusbaum, C., Jaffe, D. B., et al. (2008) · Nature · doi:10.1038/nature07107 · Cited by 2,536
Self-citationInduced pluripotent stem cells from a spinal muscular atrophy patient
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Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome
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Chromatin-Remodeling Components of the BAF Complex Facilitate Reprogramming
Singhal, N., Graumann, J., Wu, G., Araúzo-Bravo, M. J., Han, D. W., Greber, B., Gentile, L., Mann, M., & Schöler, H. R. (2010) · Cell · doi:10.1016/j.cell.2010.04.037 · Cited by 378 · cited 1×
“Clearly, much remains to be learned about the nature of the biochemical machinery involved in facilitating chromatin modification during iPSC formation (Singhal et al., 2010).”
Cited by
A census of human RNA-binding proteins
Gerstberger, S., Hafner, M., & Tuschl, T. (2014) · Nature Reviews Genetics · doi:10.1038/nrg3813 · Cited by 2,032
Rapid single-step induction of functional neurons from human pluripotent stem cells
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TET-mediated active DNA demethylation: mechanism, function and beyond
Wu, X., & Zhang, Y. (2017) · Nature Reviews Genetics · doi:10.1038/nrg.2017.33 · Cited by 1,661
Reversing DNA Methylation: Mechanisms, Genomics, and Biological Functions
Wu, H., & Zhang, Y. (2014) · Cell · doi:10.1016/j.cell.2013.12.019 · Cited by 1,065
“…the exact function of TET proteins in mouse ESCs and embryonic development, recent studies support a role for TET enzymes in transcription factor (Oct4/Klf4/Sox2/c-Myc, referred to as OKSM)-mediated reprogramming of somatic cells to induced pluripotent stem cells (iPSCs) (Hanna et al., 2010).”
InfluentialBuganim, Y., Faddah, D. A., Cheng, A. W., Itskovich, E., Markoulaki, S., Ganz, K., Klemm, S. L., van Oudenaarden, A., & Jaenisch, R. (2012) · Cell · doi:10.1016/j.cell.2012.08.023 · Cited by 793
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Metadata
- Authors
- Hanna, J. H., Saha, K., & Jaenisch, R.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2010-11
- Volume
- 143
- Issue
- 4
- Pages
- 508-525
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2155862946
- Cited by
- 698
- References
- 9
- FWCI
- 35.80
- Type
- journal article
- Language
- en
- Open access
- bronze
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