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Cited by 255

The DOI matches its Crossref record; 59 of the 59 references it cites were found in a registry or an index.

A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme

Open access
Chao, Luke H., Stratton, Margaret M., Lee, Il-Hyung, Rosenberg, Oren S., Levitz, Joshua, Mandell, Daniel J., Kortemme, Tanja, Groves, Jay T., Schulman, Howard, Kuriyan, John·2011·Cell
DOI 10.1016/j.cell.2011.07.038
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Abstract

Summary Calcium/calmodulin-dependent kinase II (CaMKII) forms a highly conserved dodecameric assembly that is sensitive to the frequency of calcium pulse trains. Neither the structure of the dodecameric assembly nor how it regulates CaMKII are known. We present the crystal structure of an autoinhibited full-length human CaMKII holoenzyme, revealing an unexpected compact arrangement of kinase domains docked against a central hub, with the calmodulin binding sites completely inaccessible. We show that this compact docking is important for the autoinhibition of the kinase domains and for setting the calcium response of the holoenzyme. Comparison of CaMKII isoforms, which differ in the length of the linker between the kinase domain and the hub, demonstrates that these interactions can be strengthened or weakened by changes in linker length. This equilibrium between autoinhibited states provides a simple mechanism for tuning the calcium response without changes in either the hub or the kinase domains.

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Crossref · 10.1016/j.cell.2011.07.038

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Metadata

Authors
Chao, L. H., Stratton, M. M., Lee, I.-H., Rosenberg, O. S., Levitz, J., Mandell, D. J., Kortemme, T., Groves, J. T., Schulman, H., & Kuriyan, J.
Venue
Cell
Publisher
Elsevier BV
Published
2011-09
Volume
146
Issue
5
Pages
732-745
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2011.07.038
OpenAlex
W2163978292
Cited by
255
References
59
FWCI
7.41
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme. https://app.cochat.ai/papers/10.1016/j.cell.2011.07.038
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Chao, L. H., Stratton, M. M., Lee, I.-H., Rosenberg, O. S., Levitz, J., Mandell, D. J., Kortemme, T., Groves, J. T., Schulman, H., & Kuriyan, J. (2011). A Mechanism for Tunable Autoinhibition in the Structure of a Human Ca2+/Calmodulin- Dependent Kinase II Holoenzyme. Cell. https://doi.org/10.1016/j.cell.2011.07.038

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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