The DOI matches its Crossref record; 66 of the 66 references it cites were found in a registry or an index.
Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids
Open accessAbstract
SUMMARY Why do opiates make human beings itch ? Spinal opioid-induced itch, a prevalent side effect of pain management, has been considered to occur as a result of pain inhibition. We report that morphine-induced scratching (MIS) is abolished in mice lacking either gastrin-releasing peptide receptor (GRPR) or the μ opioid receptor (MOR). Using exon-specific knockdown, we identified the MOR1D isoform as essential for MIS, whereas MOR1 is important for morphine-induced analgesia (MIA) with no cross activity present. MOR1D and GRPR form constitutive heterodimers in the spinal cord and relay itch information upon morphine activation. Morphine induces internalization of both GRPR and MOR1D, whereas GRP induces that of GRPR but not MOR1D, when co-expressed. Moreover, GRP-induced scratching (GIS) is independent of MOR activation. These results suggest a unidirectional cross-activation of GRPR signaling by MOR1D via heterodimerization, and that opioid-induced itch is an active process concomitant with but independent of opioid analgesia.
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Regulation of μ-opioid receptors: desensitization, phosphorylation, internalization, and tolerance
Williams, J. T., Ingram, S. L., Henderson, G., Chavkin, C., von Zastrow, M., Schulz, S., Koch, T., Evans, C. J., & Christie, M. J. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.005942 · Cited by 802
Mu Opioids and Their Receptors: Evolution of a Concept
Pasternak, G. W., & Pan, Y.-X. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.007138 · Cited by 578
Akiyama, T., & Carstens, E. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2013.07.035 · Cited by 272
A basophil-neuronal axis promotes itch
Wang, F., Trier, A. M., Li, F., Kim, S., Chen, Z., Chai, J. N., Mack, M. R., Morrison, S. A., Hamilton, J. D., Baek, J., et al. (2021) · Cell · doi:10.1016/j.cell.2020.12.033 · Cited by 264
Self-citationG protein-coupled receptor heteromers
Gomes, I., Ayoub, M. A., Fujita, W., Jaeger, W. C., Pfleger, K. D. G., & Devi, L. A. (2016) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev-pharmtox-011613-135952 · Cited by 262
Metadata
- Authors
- Liu, X.-Y., Liu, Z.-C., Sun, Y.-G., Ross, M., Kim, S., Tsai, F.-F., Li, Q.-F., Jeffry, J., Kim, J.-Y., Loh, H. H., & Chen, Z.-F.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-10
- Volume
- 147
- Issue
- 2
- Pages
- 447-458
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1997444760
- Cited by
- 291
- References
- 66
- FWCI
- 15.41
- Type
- journal article
- Language
- en
- Open access
- bronze
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- The paper
- Liu, X.-Y., Liu, Z.-C., Sun, Y.-G., Ross, M., Kim, S., Tsai, F.-F., Li, Q.-F., Jeffry, J., Kim, J.-Y., Loh, H. H., & Chen, Z.-F. (2011). Unidirectional Cross-Activation of GRPR by MOR1D Uncouples Itch and Analgesia Induced by Opioids. Cell. https://doi.org/10.1016/j.cell.2011.08.043
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