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In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse
Abstract
Delivery of therapeutic proteins into tissues and across the blood-brain barrier is severely limited by the size and biochemical properties of the proteins. Here it is shown that intraperitoneal injection of the 120-kilodalton β-galactosidase protein, fused to the protein transduction domain from the human immunodeficiency virus TAT protein, results in delivery of the biologically active fusion protein to all tissues in mice, including the brain. These results open new possibilities for direct delivery of proteins into patients in the context of protein therapy, as well as for epigenetic experimentation with model organisms.
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Cited by
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Metadata
- Authors
- Schwarze, S. R., Ho, A., Vocero-Akbani, A., & Dowdy, S. F.
- Venue
- Science
- Published
- 1999-09-03
- Volume
- 285
- Issue
- 5433
- Pages
- 1569-1572
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2105668301
- Cited by
- 2,416
- References
- 0
- FWCI
- 25.55
- Type
- journal article
- Language
- en
- Open access
- closed
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- Schwarze, S. R., Ho, A., Vocero-Akbani, A., & Dowdy, S. F. (1999). In Vivo Protein Transduction: Delivery of a Biologically Active Protein into the Mouse. Science. https://doi.org/10.1126/science.285.5433.1569
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
