The DOI matches its Crossref record; 43 of the 43 references it cites were found in a registry or an index.
The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons
Open accessAbstract
Summary Innocuous touch of the skin is detected by distinct populations of low-threshold mechanoreceptors (LTMRs), which are classified as Aβ-, Aδ- and C-LTMRs. Here, we report genetic labeling of LTMR subtypes and visualization of their relative patterns of axonal endings in hairy skin and the spinal cord. We found that each of the three major hair follicle types of trunk hairy skin; guard, awl/auchene, and zigzag hairs, is innervated by a unique and invariant combination of LTMRs; thus, each hair follicle type is a functionally distinct mechanosensory end organ. Moreover, the central projections of Aβ-, Aδ- and C-LTMRs that innervate the same or adjacent hair follicles form narrow LTMR columns in the dorsal horn. These findings support a model of mechanosensation in which the activities of Aβ-, Aδ- and C-LTMRs are integrated within dorsal horn LTMR columns and processed into outputs that underlie the perception of myriad touch sensations.
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A robust and high-throughput Cre reporting and characterization system for the whole mouse brain
Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907
A gene expression atlas of the central nervous system based on bacterial artificial chromosomes
Gong, S., Zheng, C., Doughty, M. L., Losos, K., Didkovsky, N., Schambra, U. B., Nowak, N. J., Joyner, A., Leblanc, G., Hatten, M. E., et al. (2003) · Nature · doi:10.1038/nature02033 · Cited by 2,108
Self-citationA Highly Efficient Recombineering-Based Method for Generating Conditional Knockout Mutations
Liu, P., Jenkins, N. A., & Copeland, N. G. (2003) · Genome Research · doi:10.1101/gr.749203 · Cited by 1,013
Klein, R., Nanduri, V., Jing, S., Lamballe, F., Tapley, P., Bryant, S., Cordon-Cardo, C., Jones, K. R., Reichardt, L. F., & Barbacid, M. (1991) · Cell · doi:10.1016/0092-8674(91)90628-c · Cited by 958
The structure and function of a slowly adapting touch corpuscle in hairy skin
Iggo, A., & Muir, A. R. (1969) · The Journal of Physiology · doi:10.1113/jphysiol.1969.sp008721 · Cited by 817
Recombineering: a powerful new tool for mouse functional genomics
Copeland, N. G., Jenkins, N. A., & Court, D. L. (2001) · Nature Reviews Genetics · doi:10.1038/35093556 · Cited by 739
A Diverse Family of GPCRs Expressed in Specific Subsets of Nociceptive Sensory Neurons
Dong, X., Han, S.-K., Zylka, M. J., Simon, M. I., & Anderson, D. J. (2001) · Cell · doi:10.1016/s0092-8674(01)00483-4 · Cited by 737
IB4-Binding DRG Neurons Switch from NGF to GDNF Dependence in Early Postnatal Life
Molliver, D. C., Wright, D. E., Leitner, M. L., Parsadanian, A. S., Doster, K., Wen, D., Yan, Q., & Snider, W. D. (1997) · Neuron · doi:10.1016/s0896-6273(00)80966-6 · Cited by 735
The neurophysiology of unmyelinated tactile afferents
Olausson, H., Wessberg, J., Morrison, I., McGlone, F., & Vallbo, Å. (2010) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2008.09.011 · Cited by 587
Unmyelinated afferents constitute a second system coding tactile stimuli of the human hairy skin
Vallbo, Å. B., Olausson, H., & Wessberg, J. (1999) · Journal of Neurophysiology · doi:10.1152/jn.1999.81.6.2753 · Cited by 571
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Usoskin, D., Furlan, A., Islam, S., Abdo, H., Lönnerberg, P., Lou, D., Hjerling-Leffler, J., Haeggström, J., Kharchenko, O., Kharchenko, P. V., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.3881 · Cited by 2,136
Abraira, V. E., & Ginty, D. D. (2013) · Neuron · doi:10.1016/j.neuron.2013.07.051 · Cited by 1,648
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McGlone, F., Wessberg, J., & Olausson, H. (2014) · Neuron · doi:10.1016/j.neuron.2014.05.001 · Cited by 1,112
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Bennett, D. L., Clark, A. J., Huang, J., Waxman, S. G., & Dib-Hajj, S. D. (2019) · Physiological Reviews · doi:10.1152/physrev.00052.2017 · Cited by 730
Metadata
- Authors
- Li, L., Rutlin, M., Abraira, V. E., Cassidy, C., Kus, L., Gong, S., Jankowski, M. P., Luo, W., Heintz, N., Koerber, H. R., Woodbury, C. J., & Ginty, D. D.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-12
- Volume
- 147
- Issue
- 7
- Pages
- 1615-1627
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2162056974
- Cited by
- 774
- References
- 43
- FWCI
- 18.09
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Li, L., Rutlin, M., Abraira, V. E., Cassidy, C., Kus, L., Gong, S., Jankowski, M. P., Luo, W., Heintz, N., Koerber, H. R., Woodbury, C. J., & Ginty, D. D. (2011). The Functional Organization of Cutaneous Low-Threshold Mechanosensory Neurons. Cell. https://doi.org/10.1016/j.cell.2011.11.027
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