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COSA-1 Reveals Robust Homeostasis and Separable Licensing and Reinforcement Steps Governing Meiotic Crossovers
Open accessAbstract
Summary Crossovers (COs) between homologous chromosomes ensure their faithful segregation during meiosis. We identify C. elegans COSA-1 as a key component required to convert double-strand breaks (DSBs) into COs. COSA-1 localizes to foci during late meiotic prophase that correspond to the single CO site on each homolog pair. These foci represent sites of eventual concentration of other conserved CO proteins that initially exhibit broader distribution. Chromosomes gain and lose competence to load CO proteins at DSBs during meiotic progression, with competence to load COSA-1 requiring a prior licensing event. Our data further suggest a self-reinforcing mechanism maintaining CO designation. Modeling of a non-linear dose-response relationship between IR-induced DSBs and COSA-1 foci reveals efficient conversion of DSBs into COs when DSBs are limiting, and a robust capacity to limit the number of cytologically-differentiated CO sites when DSBs are in excess. COSA-1 foci serve as a biodosimeter for DSB levels and a unique live-cell readout of CO interference.
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Metadata
- Authors
- Yokoo, R., Zawadzki, K. A., Nabeshima, K., Drake, M., Arur, S., & Villeneuve, A. M.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-03
- Volume
- 149
- Issue
- 1
- Pages
- 75-87
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2086347537
- Cited by
- 256
- References
- 59
- FWCI
- 5.46
- Type
- journal article
- Language
- en
- Open access
- bronze
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