Features and development of Coot

Coot : model-building tools for molecular graphics

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Overview of the CCP 4 suite and current developments

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Structure, function and antigenicity of the SARS-CoV-2 spike glycoprotein

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Accurate prediction of protein structures and interactions using a 3-track network

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Towards automated crystallographic structure refinement with phenix.refine

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MolProbity: More and better reference data for improved all‐atom structure validation

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Pore-forming activity and structural autoinhibition of the gasdermin family

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Cryo-EM structures of tau filaments from Alzheimer’s disease

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An oral SARS-CoV-2 M pro inhibitor clinical candidate for the treatment of COVID-19

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Cross-neutralization of SARS-CoV-2 by a human monoclonal SARS-CoV antibody

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The inner junction complex of the cilia is an interaction hub that involves tubulin post-translational modifications

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SARS-CoV-2 neutralizing antibody structures inform therapeutic strategies

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A neutralizing human antibody binds to the N-terminal domain of the Spike protein of SARS-CoV-2

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mRNA vaccine-elicited antibodies to SARS-CoV-2 and circulating variants

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Structure-based design of prefusion-stabilized SARS-CoV-2 spikes

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Potent Neutralizing Antibodies against SARS-CoV-2 Identified by High-Throughput Single-Cell Sequencing of Convalescent Patients’ B Cells

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Impact of cytosine methylation on DNA binding specificities of human transcription factors

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Structural basis of PROTAC cooperative recognition for selective protein degradation

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Structures of Cas9 endonucleases reveal RNA-mediated conformational activation

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Distinct conformational states of SARS-CoV-2 spike protein

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Large language models generate functional protein sequences across diverse families

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Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

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Structural basis of STING binding with and phosphorylation by TBK1

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Cyclic [G(2′,5′)pA(3′,5′)p] is the metazoan second messenger produced by DNA-activated cyclic GMP-AMP synthase.

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Ultra-large library docking for discovering new chemotypes

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Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases

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SARS-CoV-2 Omicron-B.1.1.529 leads to widespread escape from neutralizing antibody responses

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Structures of Human Antibodies Bound to SARS-CoV-2 Spike Reveal Common Epitopes and Recurrent Features of Antibodies

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Structure of RSV Fusion Glycoprotein Trimer Bound to a Prefusion-Specific Neutralizing Antibody

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Target Binding Properties and Cellular Activity of Afatinib (BIBW 2992), an Irreversible ErbB Family Blocker

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The target landscape of clinical kinase drugs

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Targeted inhibition of mutant IDH2 in leukemia cells induces cellular differentiation

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Pyruvate kinase M2 activators promote tetramer formation and suppress tumorigenesis

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Biochemical and Structural Analysis of Common Cancer-Associated KRAS Mutations

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Pre-fusion structure of a human coronavirus spike protein

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BNT162b vaccines protect rhesus macaques from SARS-CoV-2

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Structural basis of a shared antibody response to SARS-CoV-2

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SARS-CoV-2 Omicron variant: Antibody evasion and cryo-EM structure of spike protein–ACE2 complex

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A novel cereblon modulator recruits GSPT1 to the CRL4CRBN ubiquitin ligase

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An orally available non-nucleotide STING agonist with antitumor activity

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Automated model building and protein identification in cryo-EM maps

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Circulating SARS-CoV-2 spike N439K variants maintain fitness while evading antibody-mediated immunity

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Structure of the mechanically activated ion channel Piezo1

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A Potent and Selective Small-Molecule Degrader of STAT3 Achieves Complete Tumor Regression In Vivo

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Ultrapotent human antibodies protect against SARS-CoV-2 challenge via multiple mechanisms

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De novo protein design by deep network hallucination

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Structure and mechanogating mechanism of the Piezo1 channel

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Design of protein-binding proteins from the target structure alone

Cao, L., Coventry, B., Goreshnik, I., Huang, B., Sheffler, W., Park, J. S., Jude, K. M., Marković, I., Kadam, R. U., Verschueren, K. H. G., et al. (2022) · Nature · doi:10.1038/s41586-022-04654-9 · Cited by 577

Non-Homeostatic Body Weight Regulation Through a Brainstem-Restricted Receptor for GDF15

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Exploiting structure similarity in refinement: automated NCS and target-structure restraints in BUSTER

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Disordered methionine metabolism in MTAP/CDKN2A-deleted cancers leads to dependence on PRMT5

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Unexpected Receptor Functional Mimicry Elucidates Activation of Coronavirus Fusion

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Structural basis of SARS-CoV-2 Omicron immune evasion and receptor engagement

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Automated structure refinement of macromolecular assemblies from cryo-EM maps using Rosetta

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KAT2A coupled with the α-KGDH complex acts as a histone H3 succinyltransferase

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A selective inhibitor of PRMT5 with in vivo and in vitro potency in MCL models

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SARS-CoV-2 and bat RaTG13 spike glycoprotein structures inform on virus evolution and furin-cleavage effects

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Pan-KRAS Inhibitor Disables Oncogenic Signalling and Tumour Growth

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BAF complex vulnerabilities in cancer demonstrated via structure-based PROTAC design

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Defining the human C2H2 zinc finger degrome targeted by thalidomide analogs through CRBN

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De novo design of potent and selective mimics of IL-2 and IL-15

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Structure of the human Cereblon-DDB1-lenalidomide complex reveals basis for responsiveness to thalidomide analogs

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The structural basis for cohesin–CTCF-anchored loops

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Structure of a RING E3 ligase and ubiquitin-loaded E2 primed for catalysis

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Bioenergetic cost of making an adenosine triphosphate molecule in animal mitochondria

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Structure of Hdac3 Bound to Co-Repressor and Inositol Tetraphosphate

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Histone deacetylase 6 structure and molecular basis of catalysis and inhibition

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A highly potent and selective Vps34 inhibitor alters vesicle trafficking and autophagy

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Structure of the plastic-degrading Ideonella sakaiensis MHETase bound to a substrate

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Hachimoji DNA and RNA: A genetic system with eight building blocks.

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Molecular basis of USP7 inhibition by selective small-molecule inhibitors.

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AG-221, a First-in-Class Therapy Targeting Acute Myeloid Leukemia Harboring Oncogenic IDH2 Mutations

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SARS-CoV-2 immune evasion by the B.1.427/B.1.429 variant of concern

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Near-atomic model of microtubule-tau interactions

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Gantenerumab: A Novel Human Anti-Aβ Antibody Demonstrates Sustained Cerebral Amyloid-β Binding and Elicits Cell-Mediated Removal of Human Amyloid-β

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Structural basis for leucine sensing by the Sestrin2-mTORC1 pathway

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