Step-wise methylation of histone H3K9 positions heterochromatin at the nuclear periphery

Towbin, Benjamin D., González-Aguilera, Cristina, Sack, Ragna, Gaidatzis, Dimos, Kalck, Véronique, Meister, Peter, Askjaer, Peter, Gasser, Susan M.·2012·Cell

DOI 10.1016/j.cell.2012.06.051

Cited by (606)

Items 501–600 of 606

Automethylation of lysine methyltransferase SETDB1 on H3K9-like motifs regulates interactions with chromodomain proteins and controls its functions
Paola Cruz‐Tapias, Guillaume Velasco, Roberta Rapone, Laurence Del Maestro, Victor Cochard, Guillaume Chevreux, Véronique Joliot, Ekaterina Boyarchuk, Slimane Ait‐Si‐Ali · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Orderly mitosis shapes interphase genome architecture
Krishnendu Guin, Adib Keikhosravi, Raj Chari, Gianluca Pegoraro, Tom Misteli · 2026 · eLife
MIRAGE DNA Transposon Silencing by C. elegans Condensin II Subunit HCP-6: A Masters Thesis
Anna Malinkevich · 2014 · The Journal of the American Medical Association (JAMA) Network (American Medical Association)
Quiescence induces epigenetic changes in bovine fibroblasts and improves their reprogramming into cloned embryos
Prasanna Kumar Kallingappa · 2013 · Research Commons (University of Waikato)
Characterization of H3K56me3, a novel histone core modification
Antonia P. M. Jack · 2014 · Elektronische Hochschulschriften der LMU München (Ludwig-Maximilians-Universität München)
Gene positioning and genome function
Nidhi Vishnoi, Jie Yao · 2014 · Frontiers in Biology
Dynamics of higher order chromatin structures
Xingqi Chen · 2014 · Figshare
Interplay of chromatin remodeling, transcriptional regulation, and nuclear organization
Babett Steglich · 2015 · Figshare
Antagonistic roles of Polycomb repression and Notch signaling in the maintenance of somatic cell fate in C. elegans.
Ringo Pueschel, Francesca Coraggio, Alisha Marti, Peter Meister · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
Single-cell quantitation of histones and histone post-translational modifications across the cell cycle by high-throughput imaging
Linda K. Zane, Fleur Chapus, Gianluca Pegoraro, Tom Misteli · 2016 · bioRxiv (Cold Spring Harbor Laboratory)
Regulation of binding of HP1 associated complexes to chromatin and their role in transcription regulation in C. elegans vulva development
Yogesh B. Ostwal · 2016
An Analysis Of The Interaction Between Sin3 And Methionine Metabolism In Drosophila
Mengying Liu · 2016 · Human Biology
Global Functions of PRC2 Complexes
V. Pirrotta · 2017 · Elsevier eBooks
Systematic analysis of heterochromatin modification readout
Nadin Zimmermann · 2017
Characterizing the Molecular Changes of Austrofundulus limnaeus As It Develops Towards and Enters Diapause II
Lee S. Toni · 2015
Chromosomes and Chromatin in the Nematode Nucleus
Adriana Gonzalez‐Sandoval, Peter Meister · 2017 · Elsevier eBooks
Role of Histone Methyltransferase SET-4 in Developmental Plasticity and Longevity
Colin E. Delaney · 2017 · Deep Blue (University of Michigan)
A C. elegans histone methyltransferase promotes spermatocyte gene expression, spermatid production and fertility
Christoph Engert · 2017
KMT1/Suv39 methyltransferase family regulates peripheral heterochromatin tethering via histone and non-histone protein methylations
Radhika Arasala Rao, Alhad Ashok Ketkar, Neelam Kedia, Vignesh K Krishnamoorthy, Vairavan Lakshmanan, Pankaj Kumar, Abhishek Mohanty, Shilpa Dilip Kumar, Sufi O Raja, Akash Gulyani et al. · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
The Molecular Composition and Function of the Nuclear Periphery and Its Impact on the Genome
C. Patrick Lusk, Megan C. King · 2018 · Springer eBooks
Aberrant DNA Methylation Patterns in Gynecologic Cancers
Megan Beetch, Yunfeng Bai, Katarzyna Lubecka, Barbara Stefañska, Sophie A. Lelièvre · 2018 · Elsevier eBooks
SETting up Methylation in Mammalian Cells: Role of Histone Methyltransferases in Disease and Development
Abhishek Mohanty, Shravanti Rampalli · 2018 · Springer eBooks
Identification and Characterization of Histone H3 Lysine 23 Methylation in Germline Chromatin
Romeo Papazyan · 2014
SynMuv B Proteins Regulate Chromatin Compaction during Development
Meghan E. Costello · 2019 · e-Publications@Marquette (Marquette University)
Cell Metabolism in Cancer: An Energetic Switch
Inês Pimenta de Castro · 2019 · Learning materials in biosciences
Metabolic Cross Talk Between Cancer Cells and Tumor Microenvironment
Satish S. Poojary, Maryam Ghufran, Ananya Choudhary, Mehreen Aftab · 2020 · Springer eBooks
Sequential enrichment at the nuclear periphery of H2A.Zac and H3K9me2 accompanies pluripotency loss in human embryonic stem cells
Georgia Rose Kafer, Regina Rillo-Bohn, Peter Mark Carlton · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
A Nuclear RNA Degradation Pathway Helps Silence Polycomb/H3K27me3-Marked Loci in Caenorhabditis elegans
Anna Mattout, Dimos Gaidatzis, Véronique Kalck, Susan M. Gasser · 2019 · Cold Spring Harbor Symposia on Quantitative Biology
Characterizing the Mechanisms of Ectopic Expression of Dream Complex Target Genes and the HTA Phenotype in C. Elegans
Jerrin Roy Cherian · 2020 · e-Publications@Marquette (Marquette University)
Keratin5-BMP4 mechanosignaling regulates reciprocal acetylation and methylation at H3K9 to define blastema cell remodeling during zebrafish heart regeneration
Xuelong Wang, Huiping Guo, Feifei Yu, Wei Zheng, Hui Zhang, Ying Peng, Chenghui Wang, Gang Wei, Jizhou Yan · 2020 · bioRxiv (Cold Spring Harbor Laboratory)
A tale of two measurements: protein-DNA interactions and gene expression in single cells.
Corina M. Markodimitraki · 2020
The Epigenome through the Lens of the Transcriptome and How it Regulates Tumour Development in Cancer
Mehran Karimzadeh Reghbati · 2020 · TSpace (University of Toronto)
Point d'accès public à internet
Mairie de Roiffieux · 2010
Uncovering the role of G9a modulatory landscape promoting neuronal plasticity and neuroprotection in Alzheimer's disease
Aina Bellver‐Sanchís, Pedro Antonio Ávila-López, Júlia Companys‐Alemany, Gemma Navarro, Laura Marsal-García, Raquel Larramona‐Arcas, Lluïsa Miró, Anna Pérez‐Bosque, Daniel Ortuño‐Sahagún, Bhanwar Singh Choudhary et al. · 2022 · Research Square
Faculty Opinions recommendation of A Lamina-Associated Domain Border Governs Nuclear Lamina Interactions, Transcription, and Recombination of the Tcrb Locus.
Bas van Steensel · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Faculty Opinions recommendation of The Memory of Environmental Chemical Exposure in C. elegans Is Dependent on the Jumonji Demethylases jmjd-2 and jmjd-3/utx-1.
Peter R. Boag · 2018 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Faculty Opinions recommendation of Decoupling the downstream effects of germline nuclear RNAi reveals that H3K9me3 is dispensable for heritable RNAi and the maintenance of endogenous siRNA-mediated transcriptional silencing in Caenorhabditis elegans.
Alla Grishok, Ekaterina S. Gushchanskaia · 2017 · Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature
Epigenetic Regulation of Stem Cells
Chiara Mozzetta · 2022 · Elsevier eBooks
The Nuclear RNAi Pathway Regulates DAF-16/FOXO to Control C. elegans Longevity and Dauer Entry
Sweta Sarmah, Evandro A. De‐Souza, Silas Pinto, Adam Antebi, Marcelo A. Mori · 2022 · bioRxiv (Cold Spring Harbor Laboratory)
Tissue-specific chromatin binding patterns of C. elegans heterochromatin proteins HPL-1 and HPL-2 reveal differential roles in the regulation of gene expression
Patricia de la Cruz Ruiz, María Jesús Rodríguez‐Palero, Peter Askjaer, Marta Artal‐Sanz · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
Efficacy of auxin-inducible protein degradation in C. elegans tissues using different auxins and TIR1-expressing strains
Nidhi Sharma, Filipe Marques, Paschalis Kratsios · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
A systematic quantitative approach comprehensively defines domain-specific functional pathways linked to Schizosaccharomyces pombe heterochromatin regulation
Abubakar Muhammad, Zsuzsa Sarkadi, Thomas van Emden, Agnisrota Mazumder, Matías Capella, Gergely Fekete, Vishnu N. Suma Sreechakram, Bassem Al‐Sady, Balázs Papp, Ramón Ramos Barrales et al. · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
XOL-1 regulates developmental timing by modulating the H3K9 landscape in C. elegans early embryos
Eshna Jash, Anati Alyaa Azhar, Hector Mendoza, Zoey M. Tan, Halle Nicole Escher, Dalia S. Kaufman, Györgyi Csankovszki · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
SMCHD1 maintains heterochromatin and genome compartments in human myoblasts
Zhijun Huang, Wei Cui, Ishara S. Ratnayake, Rabi Tawil, Gerd P. Pfeifer · 2024 · bioRxiv (Cold Spring Harbor Laboratory)
Molecular Toxicology in Caenorhabditis elegans
Dayong Wang · 2022 · CABI eBooks
Moving epigenetic inheritance into the space age: Evidence that 3D genome organization is required for the establishment of epigenetic memory
Jessica J. Hawes, Alyson Ashe · 2025 · Molecular Cell
ATRX safeguards cellular identity during C. elegans development
Janie C Olver, Mariya Shtumpf, Karim Hussain, Stephen P. Methot, Peter Sarkies, Helder C. Ferreira · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Distinct regulatory mechanisms by the nuclear Argonautes HRDE-1 and NRDE-3 in the soma of Caenorhabditis elegans
Hector Mendoza, Eshna Jash, Michael B. Davis, Rebecca A. Haines, Sarah VanDiepenbos, Györgyi Csankovszki · 2025 · G3 Genes Genomes Genetics
The H3K27me3 reader UAD-2 recruits a TAF-12-containing transcription condensates to initiate piRNA expression within heterochromatic clusters
Xinya Huang, Yan Kuang, Meili Li, Minjie Hong, Demin Xu, Jiewei Cheng, Tongtong Huang, Xianlei Sun, Wenkai Wang, Ying Zhou et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Sequential action of the nuclear Argonautes HRDE-1 and NRDE-3 promotes global transcriptional silencing during starvation in the nascent C. elegans germline
Emilie Chien, Mezmur D. Belew, W. Matthew Michael · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Orderly mitosis shapes interphase genome architecture
Krishnendu Guin, Adib Keikhosravi, Raj Chari, Gianluca Pegoraro, Tom Misteli · 2025 · eLife
Nuclear lamina-associated domain biogenesis is regulated by nuclear pore density during embryogenesis and mediates UV protection
Fei Xu, Adrián Fragoso-Luna, Itai Sharon, Angelo Luiz Angonezi, Ohad Medalia, Peter Askjaer, Susan E. Mango · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Rapid canalization of chromosome conformation-transcription fingerprints during embryogenesis revealed by fully-automated cell identity decoding with CeSCALE
Κωνσταντίνος Ντέμος, Fei Xu, Nour-Zaynab Bazzi, Geoffrey Fucile, Hermina Petric Maretić, Ivan Dokmanić, Susan E. Mango, Ahilya N. Sawh · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Epigenetic control of nuclear mechanics and cellular migration via histone H3 lysine 9 methylation at Lamina-Associated Domains
Silvia Comunian, Valentin Petit, Guillaume Velasco, Vlada Zakharova, Cécile Jebane, Pauline Lahure, Véronique Joliot, Laurence Del Maestro, Magali Hennion, Guillaume Lamour et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Additional file 9 of Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
Yaxin Cao, Yan, Hengyu, Minghao Sheng, Liu, Yue, Yu, Xinyue, Li, Zhongqiu, Xu, Wenying, Su, Zhen · 2024 · Figshare
Additional file 7 of Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
Yaxin Cao, Yan, Hengyu, Minghao Sheng, Liu, Yue, Yu, Xinyue, Li, Zhongqiu, Xu, Wenying, Su, Zhen · 2024 · Figshare
Additional file 2 of Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
Yaxin Cao, Yan, Hengyu, Minghao Sheng, Liu, Yue, Yu, Xinyue, Li, Zhongqiu, Xu, Wenying, Su, Zhen · 2024 · Figshare
Additional file 11 of Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
Yaxin Cao, Yan, Hengyu, Minghao Sheng, Liu, Yue, Yu, Xinyue, Li, Zhongqiu, Xu, Wenying, Su, Zhen · 2024 · Figshare
Additional file 4 of Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
Yaxin Cao, Yan, Hengyu, Minghao Sheng, Liu, Yue, Yu, Xinyue, Li, Zhongqiu, Xu, Wenying, Su, Zhen · 2024 · Figshare
Additional file 8 of Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
Yaxin Cao, Yan, Hengyu, Minghao Sheng, Liu, Yue, Yu, Xinyue, Li, Zhongqiu, Xu, Wenying, Su, Zhen · 2024 · Figshare
Additional file 6 of Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
Yaxin Cao, Yan, Hengyu, Minghao Sheng, Liu, Yue, Yu, Xinyue, Li, Zhongqiu, Xu, Wenying, Su, Zhen · 2024 · Figshare
Additional file 1 of Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
Yaxin Cao, Yan, Hengyu, Minghao Sheng, Yue Liu, Yu, Xinyue, Li, Zhongqiu, Xu, Wenying, Su, Zhen · 2024 · Figshare
A heterochromatic histone methyltransferase lowers nucleosome occupancy at euchromatic promoters
H.M. Chen, T.B. Sackton, B. Mutlu, J. Wang, Sabine Keppler‐Ross, E. Levine, T. Liu, S.E. Mango · 2018 · bioRxiv (Cold Spring Harbor Laboratory)
Additional file 10 of Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
Yaxin Cao, Yan, Hengyu, Minghao Sheng, Liu, Yue, Yu, Xinyue, Li, Zhongqiu, Xu, Wenying, Su, Zhen · 2024 · Figshare
Additional file 5 of Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
Yaxin Cao, Yan, Hengyu, Minghao Sheng, Liu, Yue, Xinyue Yu, Li, Zhongqiu, Xu, Wenying, Su, Zhen · 2024 · Figshare
Additional file 3 of Nuclear lamina component KAKU4 regulates chromatin states and transcriptional regulation in the Arabidopsis genome
Yaxin Cao, Yan, Hengyu, Minghao Sheng, Liu, Yue, Xinyue Yu, Li, Zhongqiu, Xu, Wenying, Su, Zhen · 2024 · Figshare
Additional file 1 of Lamina-associated domains: peripheral matters and internal affairs
Nolwenn Briand, Philippe Collas · 2020 · Figshare
Methionine synthase reductase regulates heterochromatin independently of methionine synthesis through mitochondrial homeostasis
Fernanda Rezende Pabst, Andrey Tvardovskiy, Iratxe Estibariz, Veronica Finazzi, Pauline Couacault, Anna Artati, Michael A. Witting, Antonio Scialdone, Till Bartke, Robert Schneider et al. · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
Chromosome organization by Structural Maintenance of Chromosomes complexes in C. elegans
Sinem Erkan, Kalyan Ghadage, Peter Meister · 2026 · Current Opinion in Genetics & Development
Histone 3 lysine 9 dimethylation by the G9a-GLP heterodimer requires intranucleosomal product reading
Farzad Yousefi, Eric Simental, Yongming Du, Samuel D. Whedon, Michael J. Trnka, Daniel Darling, Sohpia Jia, Barbara Panning, Philip A Cole, Mario Halić et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Z-RNA-ZBP1 axis drives Tau-mediated neurodegeneration
Wei Liu, Song-Ang Wu, Bo-Xin Zhang, Shaoyu Guo, Lang Li, Wenjing Sun, Xushen Xiong, Jiuhong Nan, Jianfeng Wu, Linghui Zeng et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Chromatin tethering to the nuclear envelope enhances its accessibility to RNAPII and promotes chromatin asymmetric organization
Dana Lorber, Ido Azuri, Amit Kumar, Ron Rotkopf, Samuel A. Safran, Talila Volk · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Condensation of an H3K9me3 methyltransferase complex promotes heritable gene silencing and heterochromatin formation
Shiyu Cai, Haiqian Ma, Xinru Li, Pan Fu, Lufan Shi, Haoxiang Jia, Yuntao Liang, Yanhong Qiu, Yonglin Liang, Shuyu Hu et al. · 2026 · Cell Reports
Identification of a somatic H3K23me3 methyltransferase SET-19 in C. elegans
Mingjing Xu, Zixue Fan, Chaoyue Yan, Xiangyang Chen, Xinya Huang, Chengming Zhu, Minjie Hong, Jiewei Cheng, Xinhao Hou, Shuju Li et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Dynamique de l'organisation nucléaire des séquences d'ADN répétées centromériques humaines au cours du cycle cellulaire
Jean Ollion · 2014 · theses.fr (ABES)
Recherche de nouveaux déterminants génétiques et épigénétiques de susceptibilité à la tumorigenèse intestinale au moyen du modèle murin Apcd14
Stanislas Quesada · 2013 · theses.fr (ABES)
Biogenesis and Function of H3K9me3 at telomeres of mouse embryonic stem cells
Sophie Kan · 2015 · theses.fr (ABES)
Le HRS-Seq : une nouvelle méthode d'analyse à haut-débit des séquences génomiques associées aux compartiments nucléaires
Marie-Odile Baudement · 2015
Stable transgenerational inheritance of alternative chromatin states in Drosophila melanogaster
Filippo Ciabrelli · 2015
Mécanismes physiopathologiques de la forme AR-CMT2A de la maladie de Charcot-Marie-Tooth
Sitraka Rabarimeriarijaona · 2014
The role of the histone chaperone ASF1 in recycling parental histones during DNA replication
Camille Clément · 2018
A three-dimensional view of the interface between nuclear envelope and chromatin
Camille Samson · 2018
A trans-methylation mechanism between the two major H3K9 methyltransferases SETDB1 and SUV39H1 regulates heterochromatin establishment
Paola Cruz‐Tapias · 2018 · theses.fr (ABES)
Caenorhabditis elegans un modèle d’étude des différents compartiments du noyau : de l’étude d’un stress du nucléole par inhibition de la voie de neddylation à la mesure de la compaction de la chromatine in vivo
Aurélien Perrin · 2018 · theses.fr (ABES)
Analyse d'interactions Hox/Cofacteur à l'échelle super-résolutive et contrôle transcriptionnel de l'autophagie chez la drosophile
Solene Vanderperre · 2020
The tale of the histone H3.3 tail An essential role for the histone variant H3.3S31 residue during gastrulation in Xenopus
David Sitbon · 2018 · theses.fr (ABES)
Étude du repliement tridimensionnel de la chromatine en domaines topologiques
Quentin Szabo · 2019
Régulation et rôle de la compaction de la chromatine dans des cellules pluripotentes et lors de la différentiation
Claire Dupont · 2020
Impact of low replication stress on the replication program of cancer and non-tumor cells
Lilas Courtot · 2020 · theses.fr (ABES)
Analysis of the transcriptional basis of natural transdifferentiation initiation in Y cell using Caenorhabditis elegans as a model organism
Jaime Osuna-Luque · 2020
Regulation of heterochromatin by a pluripotency-associated long non coding RNA in mouse embryonic stem cells and in oocytes : implications for early embryogenesis
Laure D. Bernard · 2021
DNA damage-induced nuclear envelope rupture : A new cancer vulnerability
Marton Kovacs · 2023 · theses.fr (ABES)
Radial genome organization and cellular heterogeneity in quiescence
Gertjan Laenen · 2024
Identification of a somatic H3K23me3 methyltransferase SET-19 in C. elegans
Mingjing Xu, Zixue Fan, Chaoyue Yan, Xiangyang Chen, XJ Huang, Chengming Zhu, Minjie Hong, Jiewei Cheng, Xinhao Hou, Shuju Li et al. · 2026 · eLife
Identification of a somatic H3K23me3 methyltransferase SET-19 in C. elegans
Mingjing Xu, Zixue Fan, Chaoyue Yan, Xiangyang Chen, XJ Huang, Chengming Zhu, Minjie Hong, Jiewei Cheng, Xinhao Hou, Shuju Li et al. · 2026 · eLife
Nonspecific steric hindrance of protein particles by lamina-associated domains
Naz Bardakci, Aykut Erbaş, Ozan S. Sarıyer · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
Epigenetic control of telomeric RNA maintains heterochromatin in telomerase-driven cancers
Jared D. W. Price, Frederick S Vizeacoumar, Omar Abuhussein, Vincent Maranda, Yue Zhang, Hironori Adachi, Kathryn Nguyen, Liliia Kyrylenko, Aline Rangel Pozzo, He Dong et al. · 2026 · Signal Transduction and Targeted Therapy
Enzyme tethering for in situ epigenomics
Kami Ahmad, Sandipan Brahma, Derek H. Janssens, Jop Kind, Nadiya Khyzha, Michael P. Meers, Srinivas Ramachandran, Ye Zheng, Steven Henikoff · 2026 · Nature Reviews Methods Primers
Antibody-trapping presents a widespread pitfall for microscopy and genomics in the nucleus
Konrad Chudzik, Yuko Sato, Xingchi Yan, Simon Ullrich, Watanya Trakarnphornsombat, Lothar Schermelleh, Geoffrey Fudenberg, Hiroshi Kimurâ, Michael I. Robson, Irina V. Solovei · 2026 · Nucleic Acids Research
Non-coding DNA dynamics and its roles as a physical barrier in genome safeguarding across early development and evolution
Guo‐Hua Qiu, Xintian Zheng, Mingjun Fu, Cuiqin Huang · 2026 · Heredity