PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis

Yang, Weiwei, Xia, Yan, Hawke, David, Li, Xinjian, Liang, Ji, Xing, Dongming, Aldape, Kenneth, Hunter, Tony +2 more·2012·Cell

Cited by (849)

Items 601–700 of 849

  1. Vitamin-C: properties, function and application in cancer therapy
    Satish Shilpi, Roshni Shivvedi, Amrita Singh, Anil Kumar, Gaurav Kant Saraogi, Vikas Kumar Jain, Kapil Khatri · 2018 · Journal of Cancer Prevention & Current Research
  2. TKP, a Serine Protease from Trichosanthes kirilowii, Inhibits Cell Proliferation by Blocking Aerobic Glycolysis in Hepatocellular Carcinoma Cells
    Hong Zhao, Li Juan Song · 2021 · Nutrition and Cancer
  3. The role of glycolysis in immune response
    Anna S Budikhina, Mikhail V. Pashenkov · 2021 · Immunologiya
  4. PKM2 Regulates HSP90-Mediated Stability of the IGF-1R Precursor Protein and Promotes Cancer Cell Survival during Hypoxia
    Han Koo, Sangwon Byun, Jieun Seo, Yuri Jung, Dong Chul Lee, Jung Hee Cho, Young Soo Park, Young Il Yeom, Kyung Chan Park · 2021 · Cancers
  5. Insufficient pyruvate in culture medium arrests mouse embryos at the first cleavage stage associated with abnormal epigenetic modifications
    Pan Li, Hengye Zhang, Ke Yan, Lumin Sui, Ya Du, Jiahao Hu, Huiyan Xu, Xiaogan Yang, Xingwei Liang · 2022 · Theriogenology
  6. MKRN2 inhibits the proliferation of gastric cancer by downregulating PKM2
    Zheng Liu, Shuyao Xiang, Xingchen Guo, Jinghuan Zhou, Lixin Liao, Jiaxin Kou, Jun Zhang · 2022 · Aging
  7. OSU-A9 induced-reactive oxygen species cause cytotoxicity in duodenal and gastric cancer cells by decreasing phosphorylated nuclear pyruvate kinase M2 protein levels
    Chang‐Fang Chiu, Jing‐Ru Weng, Shou-Lun Lee, Chia-Yung Wu, Po‐Chen Chu, Yan‐Shen Shan, Horng-Ren Yang, Li‐Yuan Bai · 2020 · Biochemical Pharmacology
  8. Epigenomic reprogramming in iAs-mediated carcinogenesis
    Smitha George, Richard N Cassidy, Wesley N. Saintilnord, Yvonne N. Fondufe‐Mittendorf · 2022 · Advances in pharmacology
  9. Micro-RNAs in breast cancer progression and metastasis: A chromatin and metabolic perspective
    Sweta Sikder, Aditya Bhattacharya, Aayushi Agrawal, Gautam Sethi, Tapas Kumar Kundu · 2024 · Heliyon
  10. Non-metabolic enzyme function of pyruvate kinase M2 in breast cancer
    Mohammed Jemal, Mamaru Getinet, Gashaw Azanaw Amare, Bantayehu Addis Tegegne, Temesgen Baylie, Enyew Fenta Mengistu, Enatnesh Essa Osman, Nuredin Chura Waritu, Adane Adugna · 2024 · Frontiers in Oncology
  11. PRDX2 promotes gastric cancer progression by forming a feedback loop with PKM2/STAT3 axis
    Yue Zhou, Maoye Wang, Yu Qian, Dan Yu, Jiahui Zhang, Min Fu, Xiaoxin Zhang, Rong Qin, Rong Qin, Xu Zhang et al. · 2025 · Cellular Signalling
  12. PFKFB3 activates CAD to enhance de novo pyrimidine synthesis for cell growth
    Qingen Da, Yongfeng Cai, Qian Ma, Qiuhua Yang, Yapeng Cao, Yaqi Zhou, Dingwei Zhao, Zhiping Liu, Jiean Xu, Junming Quan et al. · 2025 · Cell Reports
  13. Connexin hemichannel blockade by abEC1.1 disrupts glioblastoma progression, suppresses invasiveness, and reduces hyperexcitability in preclinical models
    Viola Donati, Chiara Di Pietro, Luca Persano, Elena Rampazzo, Mariateresa Panarelli, Clara Cambria, Anna Selimi, Lorenzo Manfreda, Ana Gabriela de Oliveira do Rêgo, Gina La Sala et al. · 2025 · Cell Communication and Signaling
  14. Pyruvate Kinase M2 Role in Cardiovascular Repair
    Mohd Rihan, Lior Zangi, Ajit Magadum · 2025 · Cells
  15. Insights into Body Size Evolution: A Comparative Transcriptome Study on Three Species of Asian Sisoridae Catfish
    Wansheng Jiang, Yicheng Guo, Kunfeng Yang, Qiong Shi, Junxing Yang · 2019 · International Journal of Molecular Sciences
  16. PKM2 controls the degranulation of secondary and tertiary granules in neutrophils by phosphorylating SNAP-23
    Xinlei Sun, Dong Wang, Yan Wang, Lei Ye, Fujie Shi, Shuang Qu, Hongwei Liang, Ke Zen · 2021 · Cellular and Molecular Immunology
  17. Myeloid-Specific Pyruvate-Kinase-Type-M2-Deficient Mice Are Resistant to Acute Lung Injury
    Xinlei Sun, Fujie Shi, Weiran Wang, Yunfei Wu, Shuang Qu, Jing Li, Hongwei Liang, Ke Zen · 2022 · Biomedicines
  18. Protein kinase C epsilon promotes de novo lipogenesis and tumor growth in prostate cancer cells by regulating the phosphorylation and nuclear translocation of pyruvate kinase isoform M2
    Xiaoju Lai, Yanling Liang, Jie Jin, Hanyun Zhang, Zhicong Wu, Guihuan Li, Jinxiang Wang, Zhishuai Zhang, Hua Chen, Fangyin Zeng et al. · 2022 · Experimental Cell Research
  19. Mass spectrometric analysis reveals O-methylation of pyruvate kinase from pancreatic cancer cells
    Weidong Zhou, Michela Capello, Claudia Fredolini, Leda Racanicchi, Erica Dugnani, Lorenzo Piemonti, Lance A. Liotta, Francesco Novelli, Emanuel F. Petricoin · 2013 · Analytical and Bioanalytical Chemistry
  20. Extramitochondrial Assembly of Mitochondrial Targeting Signal Disrupted Mitochondrial Enzyme Aldehyde Dehydrogenase
    Chalongrat Noree · 2018 · Scientific Reports
  21. Polyphyllin II Induces Apoptosis in Fibrosarcoma Cells via Activating Pyruvate Kinase M2
    Jun Wu, Zhenjiang Ding, Miao Zhong, Junmin Xi, Ying He, Baoxin Zhang, Jianguo Fang · 2024 · Chemical Research in Toxicology
  22. The role of lncRNAs in the interplay of signaling pathways and epigenetic mechanisms in glioma
    Can Bora Yildiz, Jian Du, Kommu Naga Mohan, Geraldine Zimmer‐Bensch, Sara Abdolahi · 2025 · Epigenomics
  23. PKM2 knockout facilitates the activation of the AMPK/KLF4/ACADVL pathway, leading to increased oxidative degradation of fatty acids in TNBC
    Linghan Zhang, Cheng Li, Yingchao Ma, Junlin Li, Yue Zhong, Xiuzhi Zhu, XiaoMin Leng, Fuhua Xie · 2025 · Medical Oncology
  24. Reciprocal control of metabolic and chromatin regulators improves rice tolerance to heat
    Yaping Yue, Biao Liu, Qiutao Xu, Zhengting Chen, Jing Wang, Yu Jing Zhao, Dao‐Xiu Zhou · 2025 · Nature Communications
  25. Lactate binds and inhibits the innate immune sensor STING to promote tumor immune evasion
    Dong Guo, Ying Meng, Qingqing Yang, Shudi Luo, Xiaoming Jiang, Yanhua Zheng, Lihui Wu, Suyao Li, Hongfei Jiang, Shan Li et al. · 2026 · Immunity
  26. Metabolic targeting of malignant tumors: a need for systemic approach
    Aggelos T. Margetis · 2022 · Journal of Cancer Research and Clinical Oncology
  27. Pyruvate kinase M2 interacts with DNA damage-binding protein 2 and reduces cell survival upon UV irradiation
    Xiao Xie, Mingsong Wang, Ju Mei, Fengqing Hu, Fangbao Ding, Lei Lv · 2015 · Biochemical and Biophysical Research Communications
  28. Please Keep Me 2uned to PKM2
    Steven Lanier McKnight · 2014 · Molecular Cell
  29. Glutaredoxin Desensitizes Lens to Oxidative Stress by Connecting and Integrating Specific Signaling and Transcriptional Regulation for Antioxidant Response
    Qi Fan, Yonglong Zhang, Yanfeng Liu, Jin Yang, Dan Li, Yating Tang, Lei Cai, Zhennan Zhao, Peng Zhou, Yi Wei Lu · 2016 · Cellular Physiology and Biochemistry
  30. Pyruvate kinase M2 interacts with mammalian sterile 20-like kinase 1 and inhibits tamoxifen-induced apoptosis in human breast cancer cells
    Feihu Ji, Bianqin Guo, Nian Wang, Changli Zhong, Liyuan Huang, Yunxiu Huang, Lan Wei, Min Su, Yulin Jiang, Qianni Jin et al. · 2017 · Tumor Biology
  31. Amidation inhibitors 4-phenyl-3-butenoic acid and 5-(acetylamino)-4-oxo-6-phenyl-2-hexenoic acid methyl ester are novel HDAC inhibitors with anti-tumorigenic properties
    Amna Ali, Timothy J. Burns, Jacob D. Lucrezi, Sheldon W. May, George R. Green, Diane F. Matesic · 2015 · Investigational New Drugs
  32. Pyruvate Kinase M2 Links Metabolism and Epigenetics: A New Target for Liver Disease Treatment
    Xiaoya Zhang, Dao‐Lu Zhang, Jin Guo, Chunxia Shi, Zuojiong Gong · 2025 · Biomolecules
  33. Satellite Noncoding RNAs (ncRNA) as Cancer Biomarkers? New Insights from FA-SAT ncRNA Molecular and Clinical Profiles in Feline Mammary Tumors
    Daniela Ferreira, Maria Soares, Jorge Correia, Filomena Adega, Fernando Ferreira, Raquel Chaves · 2022 · OMICS A Journal of Integrative Biology
  34. Reminiscences on the honeybee genome project and the rise of epigenetic concepts in insect science
    Ryszard Maleszka · 2024 · Insect Molecular Biology
  35. Potential of PKM2 as a drug target in mouse models with type 1 diabetes mellitus
    Junbin Liu, Zhixia Li, Gan Huang, Zhiguang Zhou, Peilin Zheng · 2022 · Immunity Inflammation and Disease
  36. Creatine kinase brain-type regulates BCAR1 phosphorylation to facilitate DNA damage repair
    Bo Hee Yang, Wentao Zhang, Le Sun, Bin Lu, Changsong Yin, Yaoyang Zhang, Hong Jiang · 2023 · iScience
  37. Oncogenic Alterations of Metabolism Associated with Resistance to Chemotherapy
    Fahimeh Ghasemi, Tahereh Farkhondeh, Saeed Samarghandian, Alireza Ghasempour, Mehdi Shakibaie · 2023 · Current Molecular Medicine
  38. Extracellular pyruvate kinase M2 induces cell migration through p-Tyr42 RhoA-mediated superoxide generation and epithelial-mesenchymal transition
    Amir Hamza, Jung Yoon Cho, Kim Cuong Cap, Abu Jubayer Hossain, Jae-Gyu Kim, Jae‐Bong Park · 2023 · Free Radical Biology and Medicine
  39. Valine promotes milk synthesis by regulating PKM2 nuclear accumulation and histone H3 acetylation through the TAS1R1-mTOR-DDX39B signaling pathway
    Yu Cao, Guiqiu Hu, Xiaoyu Long, Feng Li, Jiaxin Wang, Mingyang Sun, Yachun Xie, Yusong Ge, Wenjin Guo, Juxiong Liu et al. · 2023 · International Journal of Biological Macromolecules
  40. An Insight Into the Structure–Activity Relationship Studies of Anticancer Medicinal Attributes of 7-Azaindole Derivatives: A Review
    Neha Sharma, Anurag Chaudhary, Monika Sachdeva · 2023 · Future Medicinal Chemistry
  41. Cancer Metabolism and Its Therapeutic Implications
    Weiqin Lu Craig D Logsdon, James L. Abbruzzese · 2013 · Journal of Cell Science & Therapy
  42. Histone Kinases and Phosphatases
    N.A. Watson, Jonathan M.G. Higgins · 2016 · Elsevier eBooks
  43. Downregulation of TMEM70 in Rat Liver Cells After Hepatocarcinogen Treatment Related to the Warburg Effect in Hepatocarcinogenesis Producing GST-P-Expressing Proliferative Lesions
    Sayaka Mizukami, Yousuke Watanabe, Kota Nakajima, Yasuko Hasegawa-Baba, Meilan Jin, Toshinori Yoshida, Makoto Shibutani · 2017 · Toxicological Sciences
  44. EGFRwt/vIII-PKM2-β-catenin cascade affects proliferation and chemo-sensitivity in head and neck squamous cell carcinoma.
    Chao Jing, Xin Qu, Zhaoqing Li, Chuanqiang Wu, Minghui Zhao, Yu Wang, Shanshan Sun, Shengchi Zhang, Jinliang Chen, Yu Qiao et al. · 2017 · PubMed Central
  45. Pyruvate Kinase M2 serves as blockade for nucleosome repositioning and abrogates Chd7 remodeling activity
    Kirtika Verma, Ashok Kumar Patel · 2019 · PLoS ONE
  46. Differential localization patterns of pyruvate kinase isoforms in murine naïve, formative, and primed pluripotent states
    Joshua G. Dierolf, Andrew John Watson, Dean Harvey Betts · 2021 · Experimental Cell Research
  47. FAM129B activates Ras and promotes aerobic glycolysis
    Jong-Ho Lee, Haitao Ji, Zhimin Lu · 2016 · Cell Cycle
  48. Epigenetics and alternative splicing in cancer: old enemies, new perspectives
    Madhura R. Pandkar, Sanjeev Shukla · 2024 · Biochemical Journal
  49. Unraveling Glioblastoma: TME Implication and Gene Therapy Advances
    Rohith Raali, P.K. Suresh · 2024 · Current Gene Therapy
  50. Proteomic analysis of mouse liver lesions at all three stages of Echinococcus granulosus infection
    Nan Jiang, Chen Yang, Teng Li, Yeting Sun, Yi Su, Ying Wang, Yujuan Shen, Jianping Cao · 2024 · PLoS neglected tropical diseases
  51. The mechanism of sevoflurane affecting ovarian cancer cell proliferation and migration by regulating RNA methylase TRDMT1 to activate the β-catenin pathway
    Xiaochen Huang, Xuewei Lao, Chengyan He, Jia Wang, Ying H. Pan · 2024 · Cell Biology and Toxicology
  52. The novelty of profilin 2 in regulating pyruvate kinase M2 nuclear translocation and promoting tumor angiogenesis in lung adenocarcinoma
    Xiaohui Du, Chi Ma, Yingyan Wang, Mingxin Xu, Yanbin Kuang, Mengyun Li, Shuang Wen, Peipei He, Hui Zhao, Qi Wang · 2025 · Respiratory Research
  53. Roles of Pyruvate Kinase M2 in Pulmonary Diseases: What Do We Know So Far?
    Diandian Li, Lian Liu, Jiangyue Qin, Cheng Shen, Bo Wang · 2025 · Lung
  54. Development of a one-plasmid system to replace the endogenous protein with point mutation for post-translational modification studies
    Iqra Ishrat, Aoxing Cheng, Fazhi Yu, Jing Guo, Peng Zhang, Kaiguang Zhang, Zhenye Yang · 2021 · Molecular Biology Reports
  55. Extracellular Hsp90α Supports the ePKM2-GRP78-AKT Axis to Promote Tumor Metastasis
    Shaosen Zhang, Caihong Wang, Jiujun Ju, Caixia Wang · 2022 · Frontiers in Oncology
  56. PKM2 controls the translation of TFE3 to maintain the integrity of the Golgi apparatus for the survival of HeLa and ME ‐180 cervical cancer cells
    Yuki Taguchi, Kengo Ito, Fumi Kano · 2023 · FEBS Journal
  57. Conceptualizing Eukaryotic Metabolic Sensing and Signaling
    Sunil Laxman · 2017 · Journal of the Indian Institute of Science
  58. Metabolic Reprogramming and Signaling to Chromatin Modifications in Tumorigenesis
    Zyanya Díaz-Hirashi, Tian Xiang Gao, Francisco Verdeguer · 2020 · Advances in experimental medicine and biology
  59. Proteomic Profiling of Mouse Brain Pyruvate Kinase Binding Proteins: A Hint for Moonlighting Functions of PKM1?
    О.А. Бунеева, Arthur Tigranovich Kopylov, Oksana V. Gnedenko, Марина Владимировна Медведева, Alexander V. Veselovsky, Alexis S. Ivanov, Victor Gavrilovich Zgoda, A. E. Medvedev · 2023 · International Journal of Molecular Sciences
  60. A novel protein extracted from Hemerocallis citrina Borani inhibits hepatocellular carcinoma cell proliferation by regulating mitochondria-dependent apoptosis and aerobic glycolysis
    Min You, Lixia Zhao, Li Juan Song · 2023 · Food Science and Biotechnology
  61. Molecular Components of the RCC Grade
    Tatsuto Ishimaru · 2020 · Seminars in Nephrology
  62. Supplementary Material and Methods
    Pamela C. Rosato, Eleni Anastasiadou, Nriti Garg, Dido Lenze, Francesco Boccellato, S. Vincenti, M. Severa, Eliana Marina Coccia, Riccardo Bigi, M. Cirone et al. · 2012
  63. RAC1 directly phosphorylates both PKM2 and FBP1 to promote radioresistance in hepatocellular carcinoma
    Yabo Jiang, Kaixiao Zhou, Xubiao Wei, Jinkai Feng, Bin Zhou, Chang Xin Liu, Juxian Sun, Hongfei Zhu, Zonghan Liu, Nan Yuan et al. · 2025 · Molecular Therapy
  64. PKM2 Lactylation Promotes Colorectal Cancer Vasculogenic Mimicry and Bevacizumab Resistance by Facilitating FOSL1 Super-enhancer Formation
    Weihao Li, Jianhong Peng, Jiahua He, Leen Liao, Da Kang, Weili Zhang, Weifeng Wang, Ruowei Wang, Song Wang, Yuanbin Liao et al. · 2026 · Cancer Research
  65. H3T11 phosphorylation by CKII is required for heterochromatin formation in Neurospora
    Yuan Tian, Chengcheng Zhang, Xiang Tian, Lu Zhang, Tong Yin, Yunkun Dang, Yi Liu, Huiqiang Lou, Qun He · 2024 · Nucleic Acids Research
  66. Pyruvate Kinase M1/2 Proteoformics for Accurate Insights into Energy Metabolism Abnormity to Promote the Overall Management of Ovarian Cancer Towards Predictive, Preventive, and Personalized Medicine Approaches
    Yan Wang, Nuo Xu, Marie Louise Ndzie Noah, Liang Chen, Xianquan Zhan · 2025 · Metabolites
  67. Novel targets for treating neurodegenerative diseases: The PKM2-STAT3-hnRNPA1 feedback loop
    Ping Ye, Zhen Li, Hong Jiang · 2025 · Pharmacological Research
  68. PKM2 inhibitor suppresses kidney fibrogenesis by disrupting YAP-TEAD-CCN2 transcriptional signaling following ischemia–reperfusion injury
    Wakako Kosakai, Tsutomu Inoue, Tetsuya Sato, Hirokazu Okada · 2025 · Journal of Biological Chemistry
  69. Fructose-1,6-bisphosphatase 1 suppresses PPARα-mediated gene transcription and non-small-cell lung cancer progression.
    Rongkai Shi, Jingjing Tao, Xiaoming Jiang, Min Li, Rongxuan Zhu, Shudi Luo, Zhimin Lu · 2023 · PubMed Central
  70. Elevated plasma pyruvate kinase M2 concentrations are associated with the clinical severity and prognosis of coronary artery disease
    Yu Huang, Jingkun Zhang, Xue Wu, Hang-hao Ma, Xintao Zhang, Yi‐Wei Xu, Ziwen Zhao · 2023 · Biochemia Medica
  71. Hsa_Circ_002144 Promotes Glycolysis and Immune Escape of Breast Cancer Through miR-326/PKM Axis
    Yong Yang, Tianhao Xie, Peng Gao, Weijun Han, Yuhong Liu, Yanmei Wang · 2024 · Cancer Biotherapy and Radiopharmaceuticals
  72. Extracellular PKM2 Preserves Cardiomyocytes and Reduces Cardiac Fibrosis During Myocardial Infarction
    Yang Huang, Bin Li, Zongxiang Gui, Erhe Gao, Yi Yuan, Jenny Jie Yang, Khan Hekmatyar, Falguni Mishra, Payton Chan, Zhi‐Ren Liu · 2024 · International Journal of Molecular Sciences
  73. HACD2 Promotes Pancreatic Cancer Progression by Enhancing PKM2 Dissociation From PRKN in a Dehydratase‐Independent Manner
    Xuanning Chu, Jinyu Zhao, Yuting Shen, Qi Feng, Changlin Zhou, Lingman Ma, Yu Zhou · 2025 · Advanced Science
  74. Nuclear-localized HKDC1 promotes hepatocellular carcinoma through phosphorylating RBBP5 to upregulate H3K4me3
    Ling Ye, Shengqi Shen, Qiankun Mao, Hui Juan Lu, Haiying Liu, Pinggen Zhang, Zetan Jiang, Wenhao Ma, Yuchen Sun, Yiyang Chu et al. · 2025 · Cell Reports
  75. Brain Tumor Metabolism — Unraveling Its Role in Finding New Therapeutic Targets
    Vera Miranda‐Gonçalves, Fátima Baltazar, Rui Manuel Reis · 2015 · InTech eBooks
  76. Phosphorylation of Prothymosin α. An Approach to Its Biological Significance
    Manuel Freire, Concepción S. Sarandeses, Guillermo Covelo, Cristina Dı́az-Jullien · 2016 · Vitamins and hormones
  77. Cancer Biology and the Principles of Targeted Cancer Drug Discovery
    Petra Hillmann, Debora Schmitz, Jürgen Mestan, Saana D'Allonzo, Doriano Fabbro · 2016 · Elsevier eBooks
  78. Nuclear aconitase antagonizes heterochromatic silencing by interfering with Chp1 binding to DNA
    Soo-Jin Jung, Yoonjung Choi, Daeyoup Lee, Jung‐Hye Roe · 2019 · Biochemical and Biophysical Research Communications
  79. The Potential Role of Changes in the Glucose and Lipid Metabolic Pathways in Gastrointestinal Cancer Progression: Strategy in Cancer Therapy
    Gordon A. Ferns, Milad Shahini Shams Abadi, Ahmad Raeisi, Mohammad‐Hassan Arjmand · 2021 · Gastrointestinal Tumors
  80. Identification of Histone deacetylase (HDAC)‐Associated Proteins with DNA‐Programmed Affinity Labeling
    Jianfu Zhang, Jianzhao Peng, Yiran Huang, Ling Hua Meng, Qingrong Li, Feng Xiong, Xiaoyu Li · 2020 · Angewandte Chemie
  81. Bleomycin restricts the glycolysis of lymphatic endothelial cells by inhibiting dimeric PKM2 formation: A novel mechanism for lymphatic malformation treatment
    Maosheng Chai, Rong Wang, Hao Jiang, Tianshuang Zhu, Jingjing Liu, Cong‐Fa Huang, Wenqun Zhong, Yu Cai · 2022 · Biochemical Pharmacology
  82. Identification of residues involved in allosteric signal transmission from amino acid binding site of pyruvate kinase muscle isoform 2
    Suparno Nandi, Mishtu Dey · 2023 · PLoS ONE
  83. Mechanisms of Valproic acid-Induced Autism: Canonical Wnt-β- Catenin Pathway
    Mariam Elgamal, Yasser M. Moustafa, Azza A. Ali, Norhan Mohamed El-Sayed, Dina M. Khodeer · 2023 · Records of Pharmaceutical and Biomedical Sciences/Records of Pharmaceutical & Biomedical Sciences
  84. Alterations of histone modifications in cancer
    Maha Mohamed Saber-Ayad, Wafaa S.H. Ramadan, Raafat El‐Awady · 2023 · Elsevier eBooks
  85. Crosstalk Between Histone Modifications Integrates Various Signaling Inputs to Fine-Tune Transcriptional Output
    Sankari Nagarajan, Steven A. Johnsen · 2016 · Elsevier eBooks
  86. The Eukaryotic Protein Kinase Superfamily and the Emergence of Receptor Tyrosine Kinases
    Tony R. Hunter, Gerard Manning · 2014 · Springer eBooks
  87. l ‐Cysteine Alleviates Peritoneal Fibrosis by Repressing PKM2 in Peritoneal Mesothelial Cells
    Xiaokun Ma, Yin Li, Yuebo Huang, Yuxiang Sun, Yongjie Li, Zixin Sha, Hongchun Lin, Hongli Shang, Dandan Wei, Peizhi Wu et al. · 2025 · The FASEB Journal
  88. The CLIC1-PKM2 axis orchestrates glycolytic metabolism to accelerate gastric cancer progression
    Jian Yang, Zhu Yu, Yue Feng, Shengyu Wang, Changhua Li, Yuantian Mao, Wenqian Xu, Junqiang Chen · 2025 · Journal of Translational Medicine
  89. Integrated screening for small molecules interfering with PKM2: a drug repurposing strategy against glioblastoma
    Susan Costantini, Isabella Romeo, Giulia Fanelli, Maria Serena Roca, Gianmarco Gualtieri, Palmina Bagnara, Andrea Polo, Elena Di Gennaro, Francesco Ortuso, Stefano Alcaro et al. · 2025 · Journal of Translational Medicine
  90. The Warburg effect and beyond: Glycolytic reprogramming in cancer progression and emerging therapeutic strategies
    Yuxuan Long, Jianxiong Xu, Zenan Xu, Zhengding Su, Wenfang Li, Jinyao Li · 2026 · Biomedicine & Pharmacotherapy
  91. The multiple functions and mechanisms of long non-coding RNAs in regulating breast cancer progression
    Yongsheng Zhang, Yanjiao Xu, Yanping Zhang, Shoushi Wang, Mingqiang Zhao · 2025 · Frontiers in Pharmacology
  92. Flavonoids in Brain Ischemia-Reperfusion and their Effect on Kinases as Signaling Pathway Activity
    Esra Gulsum Danis, Rasim Moğulkoç, Abdülkerim Kasım Baltacı · 2025 · CNS & Neurological Disorders - Drug Targets
  93. Four outstanding young Chinese scientists received the 2013 Scholar Award from the US Chinese Anti-Cancer Association and the National Foundation for Cancer Research
    Lifang Hou, Yan Li, Wei Zhang, Michael Yi Wang, Shi‐Yuan Cheng · 2013 · 癌症:英文版
  94. Energy metabolism of T-lymphocytes and its biological significance
    Yi Yang, Juan Feng, Silin Lü, Xian Wang · 2016 · 中国科学通报:英文版
  95. Single-Cell FISH Analysis Reveals Distinct Shifts in PKM Isoform Populations during Drug Resistance Acquisition
    Seong Ho Kim, Ji Hun Wi, HyeRan Gwak, Eun Gyeong Yang, So Yeon Kim · 2022 · Biomolecules
  96. ITPKA phosphorylates PYCR1 and promotes the progression of glioma
    Xiangying Luo, Tao Chen, Junyi Deng, Ziyuan Liu, Changlong Bi, Song Lan · 2024 · Heliyon
  97. Function of a complex of p‐ Y42 RhoA GTPase and pyruvate kinase M2 in EGF signaling pathway in glioma cells
    Yoon-Beom Lee, Yohan Park, Amir Hamza, Jung Ki Min, Oyungerel Dogsom, Sungchan Kim, Jae‐Bong Park · 2024 · Journal of Neurochemistry
  98. RNF122 promotes glioblastoma growth via the JAK2 / STAT3 /c‐Myc signaling Axis
    Qingbao Xiao, Kaming Xue, Lin Li, Kai Zhu, Rong Fu, Zhiyong Xiong · 2024 · CNS Neuroscience & Therapeutics
  99. Unveiling the anticancer potential of plumbagin: targeting pyruvate kinase M2 to induce oxidative stress and apoptosis in hepatoma cells
    Jun Wu, Zhenjiang Ding, Jingwen Tu, Alsiddig Osama, Qiuying Nie, Wenqing Cai, Baoxin Zhang · 2024 · RSC Medicinal Chemistry
  100. The role of circular RNAs in glucose metabolic reprogramming: impact on cancer progression and therapeutic implications in breast cancer
    Yiran Liang, Qifeng Yang · 2025 · Journal of Cancer Metastasis and Treatment