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A Mouse Model of Salmonella Typhi Infection
Open accessAbstract
Salmonella spp. are gram-negative flagellated bacteria that can cause food and water-borne gastroenteritis and typhoid fever in humans. We now report that flagellin from Salmonella spp. is recognized in mouse intestine by Toll-like receptor 11 (TLR11). Absence of TLR11 renders mice more susceptible to infection by S. typhimurium, with increased dissemination of the bacteria and enhanced lethality. Unlike S. typhimurium, S. typhi, a human obligatory pathogen that causes typhoid fever, is normally unable to infect mice. TLR11 is expressed in mice but not in humans, and remarkably, we find that tlr11−/− mice are efficiently infected with orally-administered S. typhi. We also find that tlr11−/− mice can be immunized against S. typhi. Therefore, tlr11−/− mice represent the first small animal model for the study of the immune response to S. typhi, and for the development of vaccines against this important human pathogen.
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Carvalho, F. A., Aitken, J. D., Gewirtz, A. T., & Vijay-Kumar, M. (2011) · Mucosal Immunology · doi:10.1038/mi.2010.57 · Cited by 80
Cited by
Toll-Like Receptor Signaling Pathways
Kawasaki, T., & Kawai, T. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00461 · Cited by 3,233
Gal-Mor, O., Boyle, E. C., & Grassl, G. A. (2014) · Frontiers in Microbiology · doi:10.3389/fmicb.2014.00391 · Cited by 566
Ganesh, B. P., Klopfleisch, R., Loh, G., & Blaut, M. (2013) · PLoS ONE · doi:10.1371/journal.pone.0074963 · Cited by 522
“[21,22] and therefore represents a highly suitable model for”
BackgroundSalmonellae interactions with host processes
LaRock, D. L., Chaudhary, A., & Miller, S. I. (2015) · Nature Reviews Microbiology · doi:10.1038/nrmicro3420 · Cited by 502
Newly described pattern recognition receptors team up against intracellular pathogens
Broz, P., & Monack, D. M. (2013) · Nature Reviews Immunology · doi:10.1038/nri3479 · Cited by 462
Metadata
- Authors
- Mathur, R., Oh, H., Zhang, D., Park, S.-G., Seo, J., Koblansky, A., Hayden, M. S., & Ghosh, S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-10
- Volume
- 151
- Issue
- 3
- Pages
- 590-602
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W1997763763
- Cited by
- 214
- References
- 1
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Mathur, R., Oh, H., Zhang, D., Park, S.-G., Seo, J., Koblansky, A., Hayden, M. S., & Ghosh, S. (2012). A Mouse Model of Salmonella Typhi Infection. Cell. https://doi.org/10.1016/j.cell.2012.08.042
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
