The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.
Reprogramming of DNA Methylation in Pollen Guides Epigenetic Inheritance via Small RNA
Open accessAbstract
Epigenetic inheritance is more widespread in plants than in mammals, in part because mammals erase epigenetic information by germline reprogramming. We sequenced the methylome of three haploid cell types from developing pollen: the sperm cell, the vegetative cell, and their precursor, the postmeiotic microspore, and found that unlike in mammals the plant germline retains CG and CHG DNA methylation. However, CHH methylation is lost from retrotransposons in microspores and sperm cells and restored by de novo DNA methyltransferase guided by 24 nt small interfering RNA, both in the vegetative nucleus and in the embryo after fertilization. In the vegetative nucleus, CG methylation is lost from targets of DEMETER (DME), REPRESSOR OF SILENCING 1 (ROS1), and their homologs, which include imprinted loci and recurrent epialleles that accumulate corresponding small RNA and are premethylated in sperm. Thus genome reprogramming in pollen contributes to epigenetic inheritance, transposon silencing, and imprinting, guided by small RNA.
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Cites
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Self-citationEpigenetic Reprogramming and Small RNA Silencing of Transposable Elements in Pollen
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Self-citationGenome-wide erasure of DNA methylation in mouse primordial germ cells is affected by AID deficiency
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Self-citationThe expanding world of small RNAs in plants
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Self-citationReconsidering plant memory: Intersections between stress recovery, RNA turnover, and epigenetics
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Molecular mechanisms of transgenerational epigenetic inheritance
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Metadata
- Authors
- Calarco, J. P., Borges, F., Donoghue, M. T. A., Van Ex, F., Jullien, P. E., Lopes, T., Gardner, R., Berger, F., Feijó, J. A., Becker, J. D., & Martienssen, R. A.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2012-09
- Volume
- 151
- Issue
- 1
- Pages
- 194-205
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2130535352
- Cited by
- 552
- References
- 57
- FWCI
- 17.89
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Calarco, J. P., Borges, F., Donoghue, M. T. A., Van Ex, F., Jullien, P. E., Lopes, T., Gardner, R., Berger, F., Feijó, J. A., Becker, J. D., & Martienssen, R. A. (2012). Reprogramming of DNA Methylation in Pollen Guides Epigenetic Inheritance via Small RNA. Cell. https://doi.org/10.1016/j.cell.2012.09.001
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