HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory

Sando, Richard, Gounko, Natalia, Pieraut, Simon, Liao, Lujian, Yates, John, Maximov, Anton·2012·Cell
DOI 10.1016/j.cell.2012.09.037

Cited by (277)

Items 201–277 of 277

  1. Behavioral Alterations in Mice Carrying Homozygous HDAC4A778T Missense Mutation Associated With Eating Disorder
    Kevin Davis, Kenji Saito, Samuel R. Rodeghiero, Brandon A. Toth, Michael L. Lutter, Huxing Cui · 2020 · Frontiers in Neuroscience
  2. Adult Hippocampal Neurogenesis Can Be Enhanced by Cold Challenge Independently From Beigeing Effects
    Jong Whi Kim, Kyu Ri Han, Woosuk Kim, Hyo Young Jung, Sung Min Nam, Dae Young Yoo, In Koo Hwang, Je Kyung Seong, Yeo Sung Yoon · 2019 · Frontiers in Neuroscience
  3. Comparison of the sensitizing effects of cocaine and ethanol on histone deacetylase isoforms in the rat brain
    Shijie Xu, Ja Wook Koo, Ung Gu Kang · 2021 · Neuroreport
  4. Targeting the HDAC4-NHE6-endosomal pH axis restores amyloid-β clearance and cognitive function in Alzheimer's disease mice
    Ningning Huang, Rui Hong, Xiaoyu Cui, Lijun Cao, Li Shi, Bin Chen, Yixuan Su, Xinru Xu, Chen Hua, Tao Ying · 2026 · Journal of Nanobiotechnology
  5. Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis
    Wei Jun Tan, Hannah R. Hawley, Sarah J. Wilson, Helen L. Fitzsimons · 2024 · BMC Biology
  6. Biological Mechanisms of Sleep/Wake-Related Function
    Robert Greene · 2025 · Biological Psychiatry
  7. Activity-dependent transcriptional programs in memory regulate motor recovery after stroke
    Mary Teena Joy, Stanley Thomas Carmichael · 2024 · Communications Biology
  8. HDAC4 /5 Inhibitor, LMK ‐235 Improves Animal Voluntary Movement in MPTP ‐Induced Parkinson's Disease Model
    Heejin Lee, Hyun‐Jin Kim, Ju‐Sik Min, Eun Hye Lee, Dong Kyu Choi, Jae‐Hyeog Choi, Yohan Seo, Sion Lee, Chun Young Im, Gi Hun Bae et al. · 2025 · Pharmacology Research & Perspectives
  9. The potential of olfaction loss to induce cognitive impairment and anxiety behavior in mice via the microbiota-gut-brain axis
    Xiangyu Zhao, Chao Xue, Yiming Wang, Xiwei Liu, Ran Li, Xianfeng Yi · 2025 · Frontiers in Microbiology
  10. N-terminal oligomerization drives HDAC4 nuclear condensation and neurodevelopmental dysfunction in Drosophila
    Hannah R. Hawley, Andrew J. Sutherland‐Smith, Matthew Scott Savoian, Helen L. Fitzsimons · 2025 · Open Biology
  11. Role of nuclear-cytoplasmic protein localization during Drosophila neuroblast development
    Sophie E. Keegan, Sarah C. Hughes · 2020 · Genome
  12. HDAC4 Inhibits NMDA Receptor-mediated Stimulation of Neurogranin Expression
    Raquel de Andrés, Elena Martínez‐Blanco, Francisco Javier Díez-Guerra · 2024 · Molecular Neurobiology
  13. Chelatable trace zinc causes low, irreproducible KDAC8 activity
    Tasha B. Toro, Samantha A. Edenfield, Brandon J. Hylton, Terry J. Watt · 2017 · Analytical Biochemistry
  14. SGK1-HDAC4-HMGB1 signaling pathway in the spinal cord dorsal horn participates in diabetic neuropathic pain
    Zhang, Mao-Biao, Chen, Jia-Li, Lu, Jia-Hui, Jia, Gai-Li, Cao, Hong, Li, Jun · 2025 · Molecular Pain
  15. Epigenetic Mechanisms of Drug Addiction Vulnerability
    Wendy Wenderski, Ian S. Maze · 2014 · Elsevier eBooks
  16. The Class II Histone Deacetylase Hypothesis of Addiction
    Edmund A. Griffin, Philippe A. Melas, Denise Bystryn Kandel, Eric R. Kandel · 2018 · Biological Psychiatry
  17. The Yin and Yang of Arnt2 in Activity-Dependent Transcription
    Zeynep Okur, Peter Scheiffele · 2019 · Neuron
  18. Sleep need driven oscillation of glutamate synaptic phenotype
    Kaspar E. Vogt, Ashwinikumar Kulkarni, Richa Pandey, Mantre Dehnad, Geneviève Konopka, Robert W. Greene · 2025 · eLife
  19. Epigenetics in Intellectual Disability
    Nathalie G. Bérubé, Jamie M. Kramer · 2014 · Elsevier eBooks
  20. Monitoring HDAC4 Expression in Alzheimer’s Disease Using [18F]TFAHA-PET
    Yi‐An Chen, Cheng-Hsiu Lu, Chien‐Chih Ke, Chi‐Wei Chang, Bang‐Hung Yang, Juri George Gelovani, Ren-Shyan Liu · 2022 · Springer proceedings in physics
  21. Transcriptional Regulation of Memory Formation
    Snehajyoti Chatterjee, Ted G. Abel · 2017 · Elsevier eBooks
  22. Novel Targets for Drug Treatment in Psychiatry
    Mitsumasa Kurita, Aintzane García‐Bea, Javier González‐Maeso · 2016 · Springer eBooks
  23. A family with brachydactyly mental retardation syndrome with a missense variant in HDAC4
    Shinji Takeyari, Kenichi Yamamoto, Makoto Fujiwara, Yasuhisa Ohata, Taichi Kitaoka, Takuo Kubota, Miho Nagata, Yasuki Ishihara, Yohei Miyashita, Yoshihiro Asano et al. · 2023 · Clinical Pediatric Endocrinology
  24. Transcriptional and epigenetic regulation of memory storage
    Ted G. Abel, Budhaditya Basu, Snehajyoti Chatterjee · 2024 · Elsevier eBooks
  25. Inhba, Homer1 and Bdnf are major targets of transcriptomic dysregulation by neurodegenerative disease-associated excitotoxic NMDA receptor signaling
    Kristin Oberländer, Priit Pruunsild, Philipp Koch, Jing Yan, Karol Szafranski, Hilmar Bading · 2025 · Communications Biology
  26. Therapeutic Potential of HDAC Inhibitors in Neurodegenerative Diseases
    Abhay Kumar Singh, Yemgadda Goutham Sudhan, Sudharshanam Lakshmi Chandana, Ashok Iyaswamy, Siva Sundara Kumar Durairajan · 2026 · Springer eBooks
  27. Histone deacetylase 4 inhibition ameliorates the social deficits induced by Ephrin-B2 mutation
    Peijun Ju, Jianhua Chen, Le Ma, Ying Cheng, Jiwei Liu, Ying Sun, Cuizhen Zhu, Zhe Shen, Wei wang, Yanmin Peng et al. · 2022 · Progress in Neuro-Psychopharmacology and Biological Psychiatry
  28. Gene Regulation by Nuclear Calcium and Its Antagonism by NMDAR/TRPM4 Signaling
    Priit Pruunsild, C. Peter Bengtson, Jing Yan, Hilmar Bading, Anna M. Hagenston · 2024 · Springer eBooks
  29. Epigenetic Post transcriptional Mutation in Neuro-Oncology
    Ankit Tripathi, Renu R. Sharma, Noopur Kejriwal, Rashmi K. Ambasta, Pravir Kumar · 2016 · Springer eBooks
  30. Histone Deacetylases as Therapeutic Targets in Neurodegenerative Diseases
    Farahnaz Sananbenesi, André Fischer · 2016 · Elsevier eBooks
  31. Synaptic Disorders
    Catalina Betancur, Kevin J. Mitchell · 2015 · Wiley eBooks
  32. Unraveling epigenetic mechanisms causing cognitive dysfunction in experimental diabetes
    Aanchal Aggarwal, Binduma Yadav, Nishtha Sharma, Raminder Kaur, Vikas Rishi · 2023 · Research Square
  33. Induction of acetylation processes in animals with serotonergic neuron dysfunction reverses their capability of long-term memory formation
    Olga V. Vorobiova, Larisa N. Grinkevich · 2014 · Russian Journal of Genetics Applied Research
  34. Epigenetic contributions to hemisphere asymmetry in healthy brain, aging, and Parkinson’s disease
    Peipei Li, Elizabeth Ensink, Sean Lang, Lee L. Marshall, Meghan Schilthuis, Jared A. Lamp, Irving E. Vega, Viviane Labrie · 2019 · bioRxiv (Cold Spring Harbor Laboratory)
  35. The antiviral mechanism and viral antagonism of host histone deacetylase 4 in influenza A virus infection
    Henry D. Galvin · 2020 · Otago University Research Archive (University of Otago)
  36. An investigation into Mef2-interacting proteins during embryonic muscle development of Drosophila
    Alina Cepraga · 2020 · ORCA Online Research @Cardiff (Cardiff University)
  37. The Role of HuD in Alternative Splicing and Alternative Polyadenylation in the Brain
    Rebecca M. Sena · 2020 · UNM’s Digital Repository (University of New Mexico)
  38. Ankyrin2 is required for neuronal morphogenesis and long-term memory and interacts genetically with HDAC4
    Silvia Schwartz, Sarah J Wilson, Tracy K. Hale, Helen L. Fitzsimons · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  39. On the discovery of ADRAM, an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3
    Xiang Li, Qiongyi Zhao, Ziqi Wang, Wei‐Siang Liau, Dean Basic, Haobin Ren, Paul Robert Marshall, Esmi Lau Zajaczkowski, Laura Jane Leighton, Sachithrani U. Madugalle et al. · 2021 · bioRxiv (Cold Spring Harbor Laboratory)
  40. Epigenetic mechanisms of drug addiction vulnerability
    Allison A. Milian, Cari J. Bendersky, Deena M. Walker · 2021 · Elsevier eBooks
  41. Sevoflurane Inhibits Histone Acetylation and Contributes to Cognitive Dysfunction by Enhancing the Expression of ANP32A in Aged Mice
    Gaoshang Chai, Jiajun Wu, Rongfei Fang, Yanlin Liu, Xuechun Wang, Xi Wang, Jinming Zhang, Jiali Zhou, Zhiqian Jiang, Haiyan Yi et al. · 2022 · SSRN Electronic Journal
  42. Role of hippocampal myocyte enhancer factor 2 (MEF2) in the neuroplastic and cognitive effects of environmental stressors
    Shuaib Syed · 2014
  43. The Effects of Bisphenol A Exposure and Calbindin Knockout on Behavior, Gene Expression, and Sexual Differentiation of the Brain
    Erin Harris · 2017
  44. Screening for Differentially Expressed Memory Genes on a Diabetes Model Induced by High-Sugar Diet in Drosophila melanogaster: Potential Markers for Memory Deficits
    Julia Sepel Loreto, Sabrina Antunes Ferreira, Pâmela de Almeida, João Batista Teixeira da Rocha, Nilda Vargas Barbosa · 2023 · Molecular Neurobiology
  45. Rapid TetOn-mediated gene expression in neurons across the lifespan with uTTOP
    Christopher K. Salmon, Gaël Quesseveur, Gee Hung Leo Cheong, Sabrina Chierzi, Miranda Green, Michael P. Rosen, Andy Y. L. Gao, J. Benjamin Kacerovsky, Keith Kazuo Murai · 2023 · bioRxiv (Cold Spring Harbor Laboratory)
  46. Histone Deacetylase Inhibitors: Design, Synthesis, and Biological Evaluation
    Sravani Pulya, Abhiram Ganorkar, Swati Biswas, Balaram Ghosh · 2023 · Springer eBooks
  47. Reviewer #2 (Public Review): Sleep need driven oscillation of glutamate synaptic phenotype
    Kaspar E. Vogt, Ashwinikumar Kulkarni, Richa Pandey · 2024 · eLife
  48. eLife Assessment: Sleep need driven oscillation of glutamate synaptic phenotype
    Amita Sehgal · 2024 · eLife
  49. Reviewer #1 (Public Review): Sleep need driven oscillation of glutamate synaptic phenotype
    Kaspar E. Vogt, Ashwinikumar Kulkarni, Richa Pandey · 2024 · eLife
  50. Sleep need driven oscillation of glutamate synaptic phenotype
    Kaspar E. Vogt, Ashwinikumar Kulkarni, Richa Pandey, Mantre Dehnad, Geneviève Konopka, Robert W. Greene · 2024 · eLife
  51. Sleep need driven oscillation of glutamate synaptic phenotype
    Kaspar E. Vogt, Ashwinikumar Kulkarni, Richa Pandey, Mantre Dehnad, Geneviève Konopka, Robert W. Greene · 2024 · eLife
  52. Development of a multigram synthetic process to clinical candidate TMP195, a class IIa histone deacetylase selective inhibitor
    Siyuan Wang, Wenchao Zhang, Qin Han, Meidi Luo, Rui Lin, Jiachen Wen, Dan Liu · 2024 · Chemical Papers
  53. Olfaction loss induces cognitive impairment and anxiety behavior in mice via the microbiota- gut-brain axis
    Xiangyu Zhao, Chao Xue, Yiming Wang, Xiwei Liu, Ran Li, Xianfeng Yi · 2024 · Research Square
  54. Sleep need driven oscillation of glutamate synaptic phenotype
    Kaspar E. Vogt, Ashwinikumar Kulkarni, Richa Pandey, Mantre Dehnad, Geneviève Konopka, Robert W. Greene · 2025 · eLife
  55. Fibroblast growth factor 21 regulates neuromuscular junction innervation through HDAC4 in denervation-induced skeletal muscle atrophy
    Lirong Zheng, Takashi Sasaki, Liyang Ni, Yu Takahashi, Yoshio Yamauchi, Makoto Shimizu, Ryuichiro Sato · 2025 · bioRxiv (Cold Spring Harbor Laboratory)
  56. Additional file 1 of Hemispheric asymmetry in the human brain and in Parkinson’s disease is linked to divergent epigenetic patterns in neurons
    Peipei Li, Elizabeth Ensink, Seán Lang, Marshall, Lee, Meghan Schilthuis, Jared A. Lamp, Irving E. Vega, Viviane Labrie · 2020 · Figshare
  57. Additional file 4 of Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis
    Wei Jun Tan, Hannah R. Hawley, Wilson, Sarah J., Helen L. Fitzsimons · 2024 · Figshare
  58. Additional file 1 of Alterations in DNA methylation associate with reduced migraine and headache days after medication withdrawal treatment in chronic migraine patients: a longitudinal study
    Divya Mehta, Irene de Boer, Sutherland, Heidi G., Judith A. Pijpers, Charlene Bron, Charlotte K. Bainomugisa, Haupt, Larisa M., van den Maagdenberg, Arn M. J. M., Lyn Robyn Griffiths, Dale R. Nyholt et al. · 2023 · Figshare
  59. Additional file 3 of Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis
    Wei Jun Tan, Hannah R. Hawley, Wilson, Sarah J., Helen L. Fitzsimons · 2024 · Figshare
  60. Additional file 12 of Hemispheric asymmetry in the human brain and in Parkinson’s disease is linked to divergent epigenetic patterns in neurons
    Peipei Li, Elizabeth Ensink, Seán Lang, Marshall, Lee, Meghan Schilthuis, Jared A. Lamp, Irving E. Vega, Viviane Labrie · 2020 · Figshare
  61. Additional file 1 of Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis
    Wei Jun Tan, Hannah R. Hawley, Wilson, Sarah J., Helen L. Fitzsimons · 2024 · Figshare
  62. Additional file 3 of Alterations in DNA methylation associate with reduced migraine and headache days after medication withdrawal treatment in chronic migraine patients: a longitudinal study
    Divya Mehta, Irene de Boer, Sutherland, Heidi G., Judith A. Pijpers, Charlene Bron, Charlotte K. Bainomugisa, Haupt, Larisa M., van den Maagdenberg, Arn M. J. M., Lyn Robyn Griffiths, Dale R. Nyholt et al. · 2024 · Figshare
  63. Additional file 2 of Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis
    Wei Jun Tan, Hannah R. Hawley, Wilson, Sarah J., Helen L. Fitzsimons · 2024 · Figshare
  64. Additional file 5 of Deciphering the roles of subcellular distribution and interactions involving the MEF2 binding region, the ankyrin repeat binding motif and the catalytic site of HDAC4 in Drosophila neuronal morphogenesis
    Wei Jun Tan, Hannah R. Hawley, Wilson, Sarah J., Helen L. Fitzsimons · 2024 · Figshare
  65. Additional file 1 of HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers
    Eros Di Giorgio, Harikrishnareddy Paluvai, Emiliano Dalla, Liliana Ranzino, Alessandra Renzini, Viviana Moresi, Martina Minisini, Raffaella Picco, Claudio Brancolini · 2021 · Figshare
  66. Additional file 9 of HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers
    Eros Di Giorgio, Harikrishnareddy Paluvai, Emiliano Dalla, Liliana Ranzino, Alessandra Renzini, Viviana Moresi, Martina Minisini, Raffaella Picco, Claudio Brancolini · 2021 · Figshare
  67. Additional file 2 of Alterations in DNA methylation associate with reduced migraine and headache days after medication withdrawal treatment in chronic migraine patients: a longitudinal study
    Divya Mehta, Irene de Boer, Sutherland, Heidi G., Judith A. Pijpers, Charlene Bron, Charlotte K. Bainomugisa, Haupt, Larisa M., Arn M.J.M. van den Maagdenberg, Lyn Robyn Griffiths, Dale R. Nyholt et al. · 2024 · Figshare
  68. Temporal and Cell‐Specific Regulation of Synaptic Homeostasis by the Chromatin Remodeler Chd1
    Danielle T. Morency, Tao Cui, Yimei Cai, Chloe Lok, Rachel E. Nokku, Ruoxian Huang, Grace L. Chu, Yumeng Xie, Saleem W. Abu‐Tayeh, Kaikai He et al. · 2026 · Advanced Science
  69. Altérations de l’expression des gènes codant pour la machinerie épigénétique dans les troubles mentaux sévères : rapports entre les paramètres centraux et périphériques
    Romain Rey · 2018 · theses.fr (ABES)
  70. SIK3-HDAC4-Warts Axis Functions as a Gatekeeper of Neural Stem Cell Reactivation in Drosophila
    Yang Gao, Amanda Yunn Ee Ng, Jiaen Lin, Hongyan Wang · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  71. Histone deacetylases in neurodegeneration and neuronal plasticity
    Bhupesh Mehta, Sinjitha Nambiar, Omkar Shirke, Satyarth Pandita, Yogananda Shamamandri Markandeya · 2026 · Methods in enzymology on CD-ROM/Methods in enzymology
  72. Mitochondrial–Epigenetic Crosstalk in Autism Spectrum Disorder: Linking Cellular Stress to Synaptic Dysfunction and Treatment Resistance
    Dijie Liu, Kai Tao, Yuxia Wang, Yuanhao Sun, Shiyong Wang · 2026 · Molecular Neurobiology
  73. Long- term administration of low doses of psilocybin causes epigenetic changes in the rat medial prefrontal cortex
    Agnieszka Wawrzczak‐Bargieła, Małgorzata Jelonek-Kozioł, Weronika Kumorek, Wiktor Bilecki, Marzena Maćkowiak · 2026 · Psychopharmacology
  74. Nup153 regulates neuronal responsiveness through HDAC1-mediated epigenetic modulation
    Abhinav Soni, Stavroula Petridi, Maria Ludovica Sforza, Diana Kluetsch, Koki Sakurai, Xin Hu, Nicole Rund, Anne Karasinsky, Julia Hernandez Pineda, Judith Houtman et al. · 2026 · bioRxiv (Cold Spring Harbor Laboratory)
  75. Epigenetic Control of Stress-Induced Depression: Emerging Roles of HDAC3 and HDAC6
    Arathy S. Mohan, Jayasankar Narayanan, Vivekanand Ankush Kashid, Ravish J. Patel, Bhupendra Gopalbhai Prajapati · 2026 · International Journal of Molecular Sciences
  76. BindingDB Entry 50016545: Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington's Disease Pathology.
    BindingDB · 2023 · UC San Diego
  77. BindingDB Entry 50018055: Zinc-dependent deacetylases (HDACs) as potential targets for treating Alzheimer's disease.
    BindingDB · 2023 · UC San Diego