HDAC4 Governs a Transcriptional Program Essential for Synaptic Plasticity and Memory

Linear Models and Empirical Bayes Methods for Assessing Differential Expression in Microarray Experiments

Smyth, G. K. (2004) · Statistical Applications in Genetics and Molecular Biology · doi:10.2202/1544-6115.1027 · Cited by 11,829 · see citing works

Adjusting batch effects in microarray expression data using empirical Bayes methods

Johnson, W. E., Li, C., & Rabinovic, A. (2007) · Biostatistics · doi:10.1093/biostatistics/kxj037 · Cited by 8,658 · see citing works

A robust and high-throughput Cre reporting and characterization system for the whole mouse brain

Madisen, L., Zwingman, T. A., Sunkin, S. M., Oh, S. W., Zariwala, H. A., Gu, H., Ng, L. L., Palmiter, R. D., Hawrylycz, M. J., Jones, A. R., et al. (2010) · Nature Neuroscience · doi:10.1038/nn.2467 · Cited by 6,907 · see citing works

The many roles of histone deacetylases in development and physiology: implications for disease and therapy

Haberland, M., Montgomery, R. L., & Olson, E. N. (2008) · Nature Reviews Genetics · doi:10.1038/nrg2485 · Cited by 2,541 · see citing works

Memory deficits associated with senescence: A neurophysiological and behavioral study in the rat.

Barnes, C. A. (1979) · Journal of Comparative and Physiological Psychology · doi:10.1037/h0077579 · Cited by 2,088 · see citing works

Germline Transmission and Tissue-Specific Expression of Transgenes Delivered by Lentiviral Vectors

Lois, C., Hong, E. J., Pease, S., Brown, E. J., & Baltimore, D. (2002) · Science · doi:10.1126/science.1067081 · Cited by 1,974 · see citing works

The molecular basis of CaMKII function in synaptic and behavioural memory

Lisman, J., Schulman, H., & Cline, H. (2002) · Nature Reviews Neuroscience · doi:10.1038/nrn753 · Cited by 1,860 · see citing works

MeCP2, a Key Contributor to Neurological Disease, Activates and Represses Transcription

Chahrour, M., Jung, S. Y., Shaw, C., Zhou, X., Wong, S. T. C., Qin, J., & Zoghbi, H. Y. (2008) · Science · doi:10.1126/science.1153252 · Cited by 1,823 · see citing works

Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders

Hardingham, G. E., & Bading, H. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2911 · Cited by 1,644 · see citing works

HDAC2 negatively regulates memory formation and synaptic plasticity

Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644 · see citing works

Dysfunction in GABA signalling mediates autism-like stereotypies and Rett syndrome phenotypes

Chao, H.-T., Chen, H., Samaco, R. C., Xue, M., Chahrour, M., Yoo, J., Neul, J. L., Gong, S., Lu, H.-C., Heintz, N., et al. (2010) · Nature · doi:10.1038/nature09582 · Cited by 1,168 · see citing works

Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation

McKinsey, T. A., Zhang, C., Lu, J., & Olson, E. N. (2000) · Nature · doi:10.1038/35040593 · Cited by 1,051 · see citing works

Class II Histone Deacetylases Act as Signal-Responsive Repressors of Cardiac Hypertrophy

Zhang, C. L., McKinsey, T. A., Chang, S., Antos, C. L., Hill, J. A., & Olson, E. N. (2002) · Cell · doi:10.1016/s0092-8674(02)00861-9 · Cited by 973 · see citing works

Signaling Mechanisms Linking Neuronal Activity to Gene Expression and Plasticity of the Nervous System

Flavell, S. W., & Greenberg, M. E. (2008) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.31.060407.125631 · Cited by 832 · see citing works

Histone Deacetylase 4 Controls Chondrocyte Hypertrophy during Skeletogenesis

Vega, R. B., Matsuda, K., Oh, J., Barbosa, A. C. C., Yang, X., Meadows, E., McAnally, J., Pomajzl, C., Shelton, J. M., Richardson, J. A., et al. (2004) · Cell · doi:10.1016/j.cell.2004.10.024 · Cited by 805 · see citing works

Behavioral phenotyping of transgenic and knockout mice: experimental design and evaluation of general health, sensory functions, motor abilities, and specific behavioral tests1Published on the World Wide Web on 2 December 1998.1

Crawley, J. N. (1999) · Brain Research · doi:10.1016/s0006-8993(98)01258-x · Cited by 762 · see citing works

Loss of Presenilin Function Causes Impairments of Memory and Synaptic Plasticity Followed by Age-Dependent Neurodegeneration

Saura, C. A., Choi, S.-Y., Beglopoulos, V., Malkani, S., Zhang, D., Rao, B. S. S., Chattarji, S., Kelleher, R. J., Kandel, E. R., Duff, K., et al. (2004) · Neuron · doi:10.1016/s0896-6273(04)00182-5 · Cited by 757 · see citing works

RankProd: a bioconductor package for detecting differentially expressed genes in meta-analysis

Hong, F., Rainer Breitling, A., McEntee, C., Wittner, B. S., Nemhauser, J. L., & Chory, J. (2006) · Bioinformatics · doi:10.1093/bioinformatics/btl476 · Cited by 753 · see citing works

MicroRNA-206 Delays ALS Progression and Promotes Regeneration of Neuromuscular Synapses in Mice

Williams, A. H., Valdez, G., Moresi, V., Qi, X., McAnally, J., Elliott, J. L., Bassel‐Duby, R., Sanes, J. R., & Olson, E. N. (2009) · Science · doi:10.1126/science.1181046 · Cited by 738 · see citing works

Neuronal MeCP2 Is Expressed at Near Histone-Octamer Levels and Globally Alters the Chromatin State

Skene, P. J., Illingworth, R. S., Webb, S., Kerr, A. R. W., James, K. D., Turner, D. J., Andrews, R., & Bird, A. P. (2010) · Molecular Cell · doi:10.1016/j.molcel.2010.01.030 · Cited by 688 · see citing works

Hebb and homeostasis in neuronal plasticity

Turrigiano, G. G., & Nelson, S. B. (2000) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(00)00091-x · Cited by 687 · see citing works

SNARE Function Analyzed in Synaptobrevin/VAMP Knockout Mice

Schoch, S., Deák, F., Königstorfer, A., Mozhayeva, M. G., Sara, Y., Südhof, T. C., & Kavalali, E. T. (2001) · Science · doi:10.1126/science.1064335 · Cited by 664 · see citing works

Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes

Bantscheff, M., Hopf, C., Savitski, M. M., Dittmann, A., Grandi, P., Michon, A.-M., Schlegl, J., Abraham, Y., Becher, I., Bergamini, G., et al. (2011) · Nature Biotechnology · doi:10.1038/nbt.1759 · Cited by 659 · see citing works

Regulation of gene expression and cocaine reward by CREB and ΔFosB

McClung, C. A., & Nestler, E. J. (2003) · Nature Neuroscience · doi:10.1038/nn1143 · Cited by 625 · see citing works

Activity-Dependent Validation of Excitatory versus Inhibitory Synapses by Neuroligin-1 versus Neuroligin-2

Chubykin, A. A., Atasoy, D., Etherton, M. R., Brose, N., Kavalali, E. T., Gibson, J. R., & Südhof, T. C. (2007) · Neuron · doi:10.1016/j.neuron.2007.05.029 · Cited by 594 · see citing works

Activity-Dependent Regulation of MEF2 Transcription Factors Suppresses Excitatory Synapse Number

Flavell, S. W., Cowan, C. W., Kim, T.-K., Greer, P. L., Lin, Y., Paradis, S., Griffith, E. C., Hu, L. S., Chen, C., & Greenberg, M. E. (2006) · Science · doi:10.1126/science.1122511 · Cited by 573 · see citing works

Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases

Lahm, A., Paolini, C., Pallaoro, M., Nardi, M. C., Jones, P., Neddermann, P., Sambucini, S., Bottomley, M. J., Lo Surdo, P., Carfı́, A., et al. (2007) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0706487104 · Cited by 566 · see citing works

Class IIa Histone Deacetylases Are Hormone-Activated Regulators of FOXO and Mammalian Glucose Homeostasis

Mihaylova, M. M., Vasquez, D. S., Ravnskjær, K., Denechaud, P., Yu, R. T., Alvarez, J. G. A., Downes, M., Evans, R. M., Montminy, M., & Shaw, R. J. (2011) · Cell · doi:10.1016/j.cell.2011.03.043 · Cited by 554 · see citing works

MeCP2 Controls Excitatory Synaptic Strength by Regulating Glutamatergic Synapse Number

Chao, H.-T., Zoghbi, H. Y., & Rosenmund, C. (2007) · Neuron · doi:10.1016/j.neuron.2007.08.018 · Cited by 511 · see citing works

An essential role for vesicular glutamate transporter 1 (VGLUT1) in postnatal development and control of quantal size

Wojcik, S. M., Rhee, J. S., Herzog, É., Sigler, A., Jahn, R., Takamori, S., Brose, N., & Rosenmund, C. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0401764101 · Cited by 510 · see citing works

AMPA Receptor Incorporation into Synapses during LTP: The Role of Lateral Movement and Exocytosis

Makino, H., & Malinow, R. (2009) · Neuron · doi:10.1016/j.neuron.2009.08.035 · Cited by 501 · see citing works

Transgenic inhibition of synaptic transmission reveals role of CA3 output in hippocampal learning

Nakashiba, T., Young, J. Z., McHugh, T. J., Buhl, D. L., & Tonegawa, S. (2008) · Science · doi:10.1126/science.1151120 · Cited by 492 · see citing works

Lentivirus-based genetic manipulations of cortical neurons and their optical and electrophysiological monitoring <i>in vivo</i>

Dittgen, T., Nimmerjahn, A., Komai, S., Licznerski, P., Waters, J., Margrie, T. W., Helmchen, F., Denk, W., Brecht, M., & Osten, P. (2004) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0407976101 · Cited by 485 · see citing works

Impairment of spatial but not contextual memory in CaMKII mutant mice with a selective loss of hippocampal ltp in the range of the θ frequency

Bach, M. E., Hawkins, R. D., Osman, M., Kandel, E. R., & Mayford, M. R. (1995) · Cell · doi:10.1016/0092-8674(95)90010-1 · Cited by 475 · see citing works

CREB's control of intrinsic and synaptic plasticity: implications for CREB-dependent memory models

Benito, E., & Barco, Á. (2010) · Trends in Neurosciences · doi:10.1016/j.tins.2010.02.001 · Cited by 450 · see citing works

The many faces of REST oversee epigenetic programming of neuronal genes

Ballas, N., & Mandel, G. (2005) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2005.08.015 · Cited by 441 · see citing works

Genome-Wide Analysis of MEF2 Transcriptional Program Reveals Synaptic Target Genes and Neuronal Activity-Dependent Polyadenylation Site Selection

Flavell, S. W., Kim, T.-K., Gray, J. M., Harmin, D. A., Hemberg, M., Hong, E. J., Markenscoff-Papadimitriou, E., Bear, D. M., & Greenberg, M. E. (2008) · Neuron · doi:10.1016/j.neuron.2008.11.029 · Cited by 440 · see citing works

Dendrite growth increased by visual activity requires NMDA receptor and Rho GTPases

Sin, W. C., Haas, K. Z., Ruthazer, E. S., & Cline, H. T. (2002) · Nature · doi:10.1038/nature00987 · Cited by 433 · see citing works

Corepressor-Dependent Silencing of Chromosomal Regions Encoding Neuronal Genes

Lunyak, V. V., Burgess, R., Prefontaine, G. G., Nelson, C., Sze, S.-H., Chenoweth, J., Schwartz, P., Pevzner, P. A., Glass, C., Mandel, G., et al. (2002) · Science · doi:10.1126/science.1076469 · Cited by 416 · see citing works

Differential Control of the Releasable Vesicle Pools by SNAP-25 Splice Variants and SNAP-23

Sørensen, J. B., Nagy, G., Varoqueaux, F., Nehring, R. B., Brose, N., Wilson, M. C., & Neher, E. (2003) · Cell · doi:10.1016/s0092-8674(03)00477-x · Cited by 364 · see citing works

The postsynaptic density proteins Homer and Shank form a polymeric network structure

Hayashi, M. K., Tang, C., Verpelli, C., Narayanan, R., Stearns, M. H., Xu, R.-M., Li, H., Sala, C., & Hayashi, Y. (2009) · Cell · doi:10.1016/j.cell.2009.01.050 · Cited by 356 · see citing works

V3 Spinal Neurons Establish a Robust and Balanced Locomotor Rhythm during Walking

Zhang, Y., Narayan, S., Geiman, E. J., Lanuza, G. M., Velasquez, T., Shanks, B., Akay, T., Dyck, J. R. B., Pearson, K. G., Gosgnach, S., et al. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.027 · Cited by 350 · see citing works

Signaling from synapse to nucleus: the logic behind the mechanisms

Deisseroth, K. A., Mermelstein, P. G., Xia, H., & Tsien, R. W. (2003) · Current Opinion in Neurobiology · doi:10.1016/s0959-4388(03)00076-x · Cited by 350 · see citing works

Disruption of LGI1–linked synaptic complex causes abnormal synaptic transmission and epilepsy

Fukata, Y., Lovero, K. L., Iwanaga, T., Watanabe, A., Yokoi, N., Tabuchi, K., Shigemoto, R., Nicoll, R. A., & Fukata, M. (2010) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0914537107 · Cited by 341 · see citing works

Complexin Controls the Force Transfer from SNARE Complexes to Membranes in Fusion

Maximov, A., Tang, J., Yang, X., Pang, Z. P., & Südhof, T. C. (2009) · Science · doi:10.1126/science.1166505 · Cited by 339 · see citing works

CYFIP/Sra-1 controls neuronal connectivity in Drosophila and links the Rac1 GTPase pathway to the fragile X protein.

Schenck, A., Bardoni, B., Langmann, C., Harden, N., Mandel, J.-L., & Giangrande, A. (2003) · Neuron · doi:10.1016/s0896-6273(03)00354-4 · Cited by 316 · see citing works

Gephyrin: where do we stand, where do we go?

Fritschy, J., Harvey, R., & Schwarz, G. (2008) · Trends in Neurosciences · doi:10.1016/j.tins.2008.02.006 · Cited by 315 · see citing works

Calcium/calmodulin-dependent protein kinase II and synaptic plasticity

Colbran, R. J., & Brown, A. M. (2004) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2004.05.008 · Cited by 307 · see citing works

Haploinsufficiency of HDAC4 Causes Brachydactyly Mental Retardation Syndrome, with Brachydactyly Type E, Developmental Delays, and Behavioral Problems

Williams, S. R., Aldred, M. A., Der Kaloustian, V. M., Halal, F., Gowans, G., McLeod, D. R., Zondag, S., Toriello, H. V., Magenis, R. E., & Elsea, S. H. (2010) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2010.07.011 · Cited by 302 · see citing works

Neuronal activity‐dependent nucleocytoplasmic shuttling of HDAC4 and HDAC5

Chawla, S., Vanhoutte, P., Arnold, F. J. L., Huang, C. L.-H., & Bading, H. (2003) · Journal of Neurochemistry · doi:10.1046/j.1471-4159.2003.01648.x · Cited by 301 · see citing works

Signaling from cAMP/PKA to MAPK and Synaptic Plasticity

Waltereit, R., & Weller, M. (2003) · Molecular Neurobiology · doi:10.1385/mn:27:1:99 · Cited by 300 · see citing works

Genome-Wide Activity-Dependent MeCP2 Phosphorylation Regulates Nervous System Development and Function

Cohen, S., Gabel, H. W., Hemberg, M., Hutchinson, A. N., Sadacca, L. A., Ebert, D. H., Harmin, D. A., Greenberg, R. S., Verdine, V. K., Zhou, Z., et al. (2011) · Neuron · doi:10.1016/j.neuron.2011.08.022 · Cited by 298 · see citing works

Synaptic trafficking of glutamate receptors by MAGUK scaffolding proteins

Elias, G. M., & Nicoll, R. A. (2007) · Trends in Cell Biology · doi:10.1016/j.tcb.2007.07.005 · Cited by 288 · see citing works

Integration of biochemical signalling in spines

Kennedy, M. B., Beale, H. C., Carlisle, H. J., & Washburn, L. R. (2005) · Nature Reviews Neuroscience · doi:10.1038/nrn1685 · Cited by 286 · see citing works

Identification of a Signal-Responsive Nuclear Export Sequence in Class II Histone Deacetylases

McKinsey, T. A., Zhang, C. L., & Olson, E. N. (2001) · Molecular and Cellular Biology · doi:10.1128/mcb.21.18.6312-6321.2001 · Cited by 285 · see citing works

SynGAP regulates synaptic strength and mitogen-activated protein kinases in cultured neurons

Rumbaugh, G., Adams, J. P., Kim, J. H., & Huganir, R. L. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0600084103 · Cited by 260 · see citing works

Adult Neural Function Requires MeCP2

McGraw, C. M., Samaco, R. C., & Zoghbi, H. Y. (2011) · Science · doi:10.1126/science.1206593 · Cited by 255 · see citing works

Disrupted Homer scaffolds mediate abnormal mGluR5 function in a mouse model of fragile X syndrome

Ronesi, J. A., Collins, K. A., Hays, S. A., Tsai, N.-P., Guo, W., Birnbaum, S. G., Hu, J.-H., Worley, P. F., Gibson, J. R., & Huber, K. M. (2012) · Nature Neuroscience · doi:10.1038/nn.3033 · Cited by 251 · see citing works

A Hormone-Dependent Module Regulating Energy Balance

Wang, B., Moya, N., Niessen, S., Hoover, H. S., Mihaylova, M. M., Shaw, R. J., Yates, J. R., Fischer, W. H., Thomas, J. B., & Montminy, M. (2011) · Cell · doi:10.1016/j.cell.2011.04.013 · Cited by 242 · see citing works

Decreased Synaptic Vesicle Recycling Efficiency and Cognitive Deficits in Amphiphysin 1 Knockout Mice

Paolo, G. D., Sankaranarayanan, S., Wenk, M. R., DANIELL, L. W., Perucco, E., Caldarone, B. J., Flavell, R. A., Picciotto, M. R., Ryan, T. A., Cremona, O., et al. (2002) · Neuron · doi:10.1016/s0896-6273(02)00601-3 · Cited by 235 · see citing works

Gene expression changes and molecular pathways mediating activity-dependent plasticity in visual cortex

Tropea, D., Kreiman, G., Lyckman, A., Mukherjee, S., Yu, H., Horng, S., & Sur, M. (2006) · Nature Neuroscience · doi:10.1038/nn1689 · Cited by 226 · see citing works

NMDA Receptors Activated by Subventricular Zone Astrocytic Glutamate Are Critical for Neuroblast Survival Prior to Entering a Synaptic Network

Platel, J., Dave, K. A., Gordon, V., Lacar, B., Rubio, M. E., & Bordey, A. (2010) · Neuron · doi:10.1016/j.neuron.2010.03.009 · Cited by 225 · see citing works

Distinct FGFs promote differentiation of excitatory and inhibitory synapses

Terauchi, A., Johnson-Venkatesh, E., Toth, A. B., Javed, D., Sutton, M. A., & Umemori, H. (2010) · Nature · doi:10.1038/nature09041 · Cited by 214 · see citing works

Nuclear accumulation of HDAC4 in ATM deficiency promotes neurodegeneration in ataxia telangiectasia

Li, J., Chen, J., Ricupero, C. L., Hart, R. P., Schwartz, M. S., Kusnecov, A., & Herrup, K. (2012) · Nature Medicine · doi:10.1038/nm.2709 · Cited by 210 · see citing works

SynGAP regulates spine formation

Vazquez, L. E., Chen, H.-J., Sokolova, I., Knuesel, I., & Kennedy, M. B. (2004) · The Journal of Neuroscience · doi:10.1523/jneurosci.3213-04.2004 · Cited by 203 · see citing works

Rab3 superprimes synaptic vesicles for release: implications for short-term synaptic plasticity

Schlüter, O. M., Basu, J., Südhof, T. C., & Rosenmund, C. (2006) · The Journal of Neuroscience · doi:10.1523/jneurosci.3553-05.2006 · Cited by 199 · see citing works

HDAC4 Regulates Neuronal Survival in Normal and Diseased Retinas

Chen, B., & Cepko, C. L. (2009) · Science · doi:10.1126/science.1166226 · Cited by 192 · see citing works

Intracellular Trafficking of Histone Deacetylase 4 Regulates Neuronal Cell Death

Bolger, T. A., & Yao, T. (2005) · Journal of Neuroscience · doi:10.1523/jneurosci.1826-05.2005 · Cited by 190 · see citing works

Synaptic Roles of Cdk5: Implications in Higher Cognitive Functions and Neurodegenerative Diseases

Cheung, Z. H., Fu, A. K. Y., & Ip, N. Y. (2006) · Neuron · doi:10.1016/j.neuron.2006.02.024 · Cited by 182 · see citing works

Neto1 Is a Novel CUB-Domain NMDA Receptor–Interacting Protein Required for Synaptic Plasticity and Learning

Ng, D., Pitcher, G. M., Szilard, R. K., Sertie, A. L., Kanisek, M., Clapcote, S. J., Lipina, T. V., Kalia, L. V., Joo, D. T., McKerlie, C., et al. (2009) · PLoS Biology · doi:10.1371/journal.pbio.1000041 · Cited by 180 · see citing works

The Transcriptional Coactivator CAMTA2 Stimulates Cardiac Growth by Opposing Class II Histone Deacetylases

Song, K., Backs, J., McAnally, J., Qi, X., Gerard, R. D., Richardson, J. A., Hill, J. A., Bassel‐Duby, R., & Olson, E. N. (2006) · Cell · doi:10.1016/j.cell.2006.02.048 · Cited by 179 · see citing works

SV2 Renders Primed Synaptic Vesicles Competent for Ca²⁺-Induced Exocytosis

Chang, W.-P., & Südhof, T. C. (2009) · The Journal of Neuroscience · doi:10.1523/jneurosci.4521-08.2009 · Cited by 176 · see citing works

Neurotransmission selectively regulates synapse formation in parallel circuits in vivo

Kerschensteiner, D., Morgan, J., Parker, E. D., Lewis, R. M., & Wong, R. (2009) · Nature · doi:10.1038/nature08236 · Cited by 175 · see citing works

A Neural Tetraspanin, Encoded by late bloomer , That Facilitates Synapse Formation

Kopczynski, C., Davis, G. W., & Goodman, C. S. (1996) · Science · doi:10.1126/science.271.5257.1867 · Cited by 170 · see citing works

Effects of visual experience on activity-dependent gene regulation in cortex

Majdan, M., & Shatz, C. J. (2006) · Nature Neuroscience · doi:10.1038/nn1674 · Cited by 158 · see citing works

DYRK1A-Dosage Imbalance Perturbs NRSF/REST Levels, Deregulating Pluripotency and Embryonic Stem Cell Fate in Down Syndrome

Canzonetta, C., Mulligan, C., Deutsch, S., Ruf, S., O’Doherty, A., Lyle, R., Borel, C., Lin-Marq, N., Delom, F., Groet, J., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.08.012 · Cited by 158 · see citing works

Histone Deacetylases 1 and 2 Form a Developmental Switch That Controls Excitatory Synapse Maturation and Function

Akhtar, M. W., Raingo, J., Nelson, E. D., Montgomery, R. L., Olson, E. N., Kavalali, E. T., & Monteggia, L. M. (2009) · Journal of Neuroscience · doi:10.1523/jneurosci.0097-09.2009 · Cited by 151 · see citing works

Protein serine/threonine phosphatases in neuronal plasticity and disorders of learning and memory

Mansuy, I. M., & Shenolikar, S. (2006) · Trends in Neurosciences · doi:10.1016/j.tins.2006.10.004 · Cited by 151 · see citing works

Activity-Dependent IGF-1 Exocytosis is Controlled by the Ca2+-Sensor Synaptotagmin-10

Cao, P., Maximov, A., & Südhof, T. (2011) · Cell · doi:10.1016/j.cell.2011.03.034 · Cited by 149 · see citing works

Regulation of HDAC9 Gene Expression by MEF2 Establishes a Negative-Feedback Loop in the Transcriptional Circuitry of Muscle Differentiation

Haberland, M., Arnold, M., McAnally, J., Phan, D., Kim, Y., & Olson, E. N. (2006) · Molecular and Cellular Biology · doi:10.1128/mcb.01415-06 · Cited by 149 · see citing works

Selective repression of MEF2 activity by PKA-dependent proteolysis of HDAC4

Backs, J., Worst, B. C., Lehmann, L., Patrick, D. M., Jebessa, Z. H., Kreußer, M. M., Sun, Q., Chen, L., Heft, C., Katus, H. A., et al. (2011) · The Journal of Cell Biology · doi:10.1083/jcb.201105063 · Cited by 148 · see citing works

Oligodendrocyte-Myelin Glycoprotein and Nogo Negatively Regulate Activity-Dependent Synaptic Plasticity

Raiker, S. J., Lee, H., Baldwin, K. T., Duan, Y., Shrager, P. G., & Giger, R. J. (2010) · Journal of Neuroscience · doi:10.1523/jneurosci.0895-10.2010 · Cited by 145 · see citing works

Protein Phosphatases and Calcium/Calmodulin-Dependent Protein Kinase II-Dependent Synaptic Plasticity: Figure 1.

Colbran, R. J. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.3602-04.2004 · Cited by 139 · see citing works

HDAC4 inhibits cell‐cycle progression and protects neurons from cell death

Majdzadeh, N., Wang, L., Morrison, B. E., Bassel‐Duby, R., Olson, E. N., & D’Mello, S. R. (2008) · Developmental Neurobiology · doi:10.1002/dneu.20637 · Cited by 134 · see citing works

Activity-dependent synaptogenesis in the adult Mammalian cortex

Zito, K., & Svoboda, K. (2002) · Neuron · doi:10.1016/s0896-6273(02)00903-0 · Cited by 134 · see citing works

Activity-regulated genes as mediators of neural circuit plasticity

Leslie, J. H., & Nedivi, E. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.002 · Cited by 133 · see citing works

Regulation of spine and synapse formation by activity-dependent intracellular signaling pathways

Saneyoshi, T., Fortin, D. A., & Soderling, T. R. (2010) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2009.09.013 · Cited by 133 · see citing works

A Calcium-Dependent Switch in a CREST-BRG1 Complex Regulates Activity-Dependent Gene Expression

Qiu, Z., & Ghosh, A. (2008) · Neuron · doi:10.1016/j.neuron.2008.09.040 · Cited by 125 · see citing works

The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses

Smalla, K., Matthies, H. K., Langnäse, K., Shabir, S., Böckers, T. M., Wyneken, Ú., Staak, S., Krug, M., Beesley, P. W., & Gundelfinger, E. D. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.080389297 · Cited by 124 · see citing works

The stress-regulated protein M6a is a key modulator for neurite outgrowth and filopodium/spine formation

Alfonso, J., Fernández, M. E., Cooper, B. H., Flügge, G., & Frasch, A. C. C. (2005) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0504262102 · Cited by 120 · see citing works

IgLON cell adhesion molecules regulate synaptogenesis in hippocampal neurons

Hashimoto, T., Maekawa, S., & Miyata, S. (2009) · Cell Biochemistry and Function · doi:10.1002/cbf.1600 · Cited by 117 · see citing works

cAMP Response Element-Binding Protein Is a Primary Hub of Activity-Driven Neuronal Gene Expression

Benito, E., Valor, L. M., Jimenez-Minchan, M., Huber, W. K., & Barco, Á. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.4554-11.2011 · Cited by 117 · see citing works

α2-Chimaerin Is an Essential EphA4 Effector in the Assembly of Neuronal Locomotor Circuits

Beg, A. A., Sommer, J. E., Martin, J. H., & Scheiffele, P. (2007) · Neuron · doi:10.1016/j.neuron.2007.07.036 · Cited by 115 · see citing works

A Conserved Role for Drosophila Neuroglian and Human L1-CAM in Central-Synapse Formation

Godenschwege, T. A., Kristiansen, L. V., Uthaman, S. B., Hortsch, M., & Murphey, R. K. (2006) · Current Biology · doi:10.1016/j.cub.2005.11.062 · Cited by 114 · see citing works

Synaptotagmin-12, a synaptic vesicle phosphoprotein that modulates spontaneous neurotransmitter release

Maximov, A., Shin, O., Liu, X., & Südhof, T. C. (2006) · The Journal of Cell Biology · doi:10.1083/jcb.200607021 · Cited by 112 · see citing works

Importin-mediated retrograde transport of CREB2 from distal processes to the nucleus in neurons

Lai, K.-O., Zhao, Y., Ch'ng, T. H., & Martin, K. C. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0803906105 · Cited by 106 · see citing works

Synaptic Targeting and Functional Modulation of GluK1 Kainate Receptors by the Auxiliary Neuropilin and Tolloid-Like (NETO) Proteins

Copits, B. A., Robbins, J. S., Frausto, S. F., & Swanson, G. T. (2011) · Journal of Neuroscience · doi:10.1523/jneurosci.0100-11.2011 · Cited by 104 · see citing works

Isoform specificity of protein kinase Cs in synaptic plasticityPreprint

Sossin, W. S. (2007) · Learning & Memory · doi:10.1101/lm.469707 · Cited by 102 · see citing works

Determinants of postsynaptic Ca2+ signaling in Purkinje neurons

Hartmann, J., & Konnerth, A. (2005) · Cell Calcium · doi:10.1016/j.ceca.2005.01.014 · Cited by 96 · see citing works

The Roles of MAPK Cascades in Synaptic Plasticity and Memory in <i>Aplysia</i>: Facilitatory Effects and Inhibitory Constraints: Figure 1

Sharma, S. K., & Carew, T. J. (2004) · Learning &amp; Memory · doi:10.1101/lm.81104 · Cited by 95 · see citing works

Mutations in Contactin-1, a Neural Adhesion and Neuromuscular Junction Protein, Cause a Familial Form of Lethal Congenital Myopathy

Compton, A. G., Albrecht, D. E., Seto, J. T., Cooper, S. T., Ilkovski, B., Jones, K., Challis, D. E., Mowat, D. R., Ranscht, B., Bahlo, M., et al. (2008) · The American Journal of Human Genetics · doi:10.1016/j.ajhg.2008.10.022 · Cited by 83 · see citing works

Repressor element 1 silencing transcription factor (REST) controls radial migration and temporal neuronal specification during neocortical development

Mandel, G., Fiondella, C. G., Covey, M. V., Lu, D. D., LoTurco, J. J., & Ballas, N. (2011) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1113486108 · Cited by 83 · see citing works

Presynaptic CaV2 calcium channel traffic requires CALF-1 and the α2δ subunit UNC-36

Saheki, Y., & Bargmann, C. I. (2009) · Nature Neuroscience · doi:10.1038/nn.2383 · Cited by 82 · see citing works

Neurobeachin Is Essential for Neuromuscular Synaptic Transmission

Su, Y., Balice‐Gordon, R. J., Hess, D. M., Landsman, D., Minarcik, J. C., Golden, J. A., Hurwitz, I., Liebhaber, S. A., & Cooke, N. E. (2004) · Journal of Neuroscience · doi:10.1523/jneurosci.4644-03.2004 · Cited by 82 · see citing works

Synapsins regulate use-dependent synaptic plasticity in the calyx of Held by a Ca 2+ /calmodulin-dependent pathway

Sun, J., Bronk, P., Liu, X., Han, W., & Südhof, T. C. (2006) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0511300103 · Cited by 79 · see citing works

Synapse-to-nucleus signaling

Ch’ng, T. H., & Martin, K. C. (2011) · Current Opinion in Neurobiology · doi:10.1016/j.conb.2011.01.011 · Cited by 73 · see citing works

Regional and subcellular distribution of HDAC4 in mouse brain

Darcy, M. J., Calvin, K., Cavnar, K., & Ouimet, C. C. (2010) · Journal of Comparative Neurology · doi:10.1002/cne.22241 · Cited by 69 · see citing works

Laminar organization of the early developing anterior hypothalamus

Caqueret, A., Boucher, F., & Michaud, J. L. (2006) · Developmental Biology · doi:10.1016/j.ydbio.2006.06.019 · Cited by 56 · see citing works

NECABs: a family of neuronal Ca(2+)-binding proteins with an unusual domain structure and a restricted expression pattern.

Sugita, S., Ho, A., & Südhof, T. (2002) · Neuroscience · doi:10.1016/s0306-4522(02)00063-5 · Cited by 54 · see citing works

Diacylglycerol kinases in the regulation of dendritic spines

Kim, K., Yang, J., & Kim, E. (2009) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2009.06499.x · Cited by 48 · see citing works

Subcellular organization of GABAergic synapses: role of ankyrins and L1 cell adhesion molecules

Huang, Z. J. (2006) · Nature Neuroscience · doi:10.1038/nn1638 · Cited by 41 · see citing works

The yin and yang of MeCP2 phosphorylation

Chao, H., & Zoghbi, H. Y. (2009) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0901518106 · Cited by 37 · see citing works

Mutational Analysis Establishes a Critical Role for the N Terminus of Fragile X Mental Retardation Protein FMRP

Reeve, S. P., Lin, X., Şahin, H. B., Jiang, F., Yao, A., Liu, Z., Zhi, H., Broadie, K. S., Li, W., Giangrande, A., et al. (2008) · Journal of Neuroscience · doi:10.1523/jneurosci.5528-07.2008 · Cited by 29 · see citing works

SP1 regulates a human SNAP‐25 gene expression

Cai, F., Chen, B., Zhou, W., Zis, O., Liu, S., Holt, R. A., Honer, W. G., & Song, W. (2007) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2007.05167.x · Cited by 24 · see citing works

The Kelch-like protein 1 modulates P/Q-type calcium current density

Aromolaran, K. A., Benzow, K. A., Koob, M. D., & Piedras-Renterı́a, E. S. (2007) · Neuroscience · doi:10.1016/j.neuroscience.2006.12.046 · Cited by 22 · see citing works

Scrg1, a novel protein of the CNS is targeted to the large dense‐core vesicles in neuronal cells

Dandoy‐Dron, F., Griffond, B., Mishal, Z., Tovey, M. G., & Dron, M. (2003) · European Journal of Neuroscience · doi:10.1046/j.1460-9568.2003.03009.x · Cited by 18 · see citing works

Endogenous RGS Proteins Regulate Presynaptic and Postsynaptic Function: Functional Expression of RGS-Insensitive Gα Subunits in Central Nervous System Neurons

Chen, H., CLARK, M. A., & Lambert, N. A. (2004) · Methods in enzymology on CD-ROM/Methods in enzymology · doi:10.1016/s0076-6879(04)89012-8 · Cited by 11 · see citing works

Moesin helps to restrain synaptic growth at the Drosophila neuromuscular junction

Seabrooke, S., & Stewart, B. A. (2007) · Developmental Neurobiology · doi:10.1002/dneu.20595 · Cited by 10 · see citing works

From the genetic architecture to synaptic plasticity in autism spectrum disorder

Bourgeron, T. (2015) · Nature Reviews Neuroscience · doi:10.1038/nrn3992 · Cited by 975 · see citing works

From neural development to cognition: unexpected roles for chromatin

Ronan, J. L., Wu, W., & Crabtree, G. R. (2013) · Nature Reviews Genetics · doi:10.1038/nrg3413 · Cited by 544 · see citing works

Histone Deacetylases (HDACs): Evolution, Specificity, Role in Transcriptional Complexes, and Pharmacological Actionability

Milazzo, G., Mercatelli, D., Muzio, G. D., Triboli, L., Rosa, P. D., Perini, G., & Giorgi, F. M. (2020) · Genes · doi:10.3390/genes11050556 · Cited by 431 · see citing works

Nuclear calcium signalling in the regulation of brain function

Bading, H. (2013) · Nature reviews. Neuroscience · doi:10.1038/nrn3531 · Cited by 374 · see citing works

DNA methylation analysis of the autistic brain reveals multiple dysregulated biological pathways

Nardone, S., Sharan Sams, D., Reuveni, E., Getselter, D., Oron, O., Karpuj, M., & Elliott, E. (2014) · Translational Psychiatry · doi:10.1038/tp.2014.70 · Cited by 266 · see citing works

Brain changes in a maternal immune activation model of neurodevelopmental brain disorders

Bergdolt, L., & Dunaevsky, A. (2018) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2018.12.002 · Cited by 266 · see citing works

Alzheimer’s Disease: From Firing Instability to Homeostasis Network Collapse

Frère, S. G. A., & Slutsky, I. (2018) · Neuron · doi:10.1016/j.neuron.2017.11.028 · Cited by 230 · see citing works

Epigenetic regulation in major depression and other stress-related disorders: molecular mechanisms, clinical relevance and therapeutic potential

Yuan, M., Yang, B., Rothschild, G., Mann, J. J., Sanford, L. D., Tang, X., Huang, C., Wang, C., & Zhang, W. (2023) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-023-01519-z · Cited by 246 · see citing works

Progress toward treatments for synaptic defects in autism

Delorme, R., Ey, E., Toro, R., Leboyer, M., Gillberg, C., & Bourgeron, T. (2013) · Nature Medicine · doi:10.1038/nm.3193 · Cited by 218 · see citing works

Understanding the role of histone deacetylase and their inhibitors in neurodegenerative disorders: current targets and future perspective

Kumar, V., Kundu, S., Singh, A., & Singh, S. (2022) · Current Neuropharmacology · doi:10.2174/1570159x19666210609160017 · Cited by 210 · see citing works

Class II a HDAC s – new insights into their functions in physiology and pathology

Parra, M. (2014) · FEBS Journal · doi:10.1111/febs.13061 · Cited by 194 · see citing works

MicroRNA-29a Promotion of Nephrin Acetylation Ameliorates Hyperglycemia-Induced Podocyte Dysfunction

Lin, C., Lee, P., Hsu, Y., Lei, C., Ko, J., Chuang, P.-C., Huang, Y., Wang, S.-Y., Wu, S.-L., Chen, Y., et al. (2014) · Journal of the American Society of Nephrology · doi:10.1681/asn.2013050527 · Cited by 193 · see citing works

The Mendelian disorders of the epigenetic machineryPreprint

Bjornsson, H. T. (2015) · Genome Research · doi:10.1101/gr.190629.115 · Cited by 192 · see citing works

CaMKII Isoforms in Learning and Memory: Localization and Function

Zalcman, G., Federman, N., & Romano, A. G. (2018) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2018.00445 · Cited by 185 · see citing works

TNFα and IL-1β modify the miRNA cargo of astrocyte shed extracellular vesicles to regulate neurotrophic signaling in neurons

Chaudhuri, A. D., Dastgheyb, R. M., Yoo, S.-W., Trout, A., Talbot Jr, C. C., Hao, H., Witwer, K. W., & Haughey, N. J. (2018) · Cell Death &amp; Disease · doi:10.1038/s41419-018-0369-4 · Cited by 184 · see citing works

Epigenetic mechanisms of major depression: Targeting neuronal plasticity

Uchida, S., Yamagata, H., Seki, T., & Watanabe, Y. (2018) · Psychiatry and Clinical Neurosciences · doi:10.1111/pcn.12621 · Cited by 181 · see citing works

How the epigenome integrates information and reshapes the synapse

Campbell, R. R., & Wood, M. A. (2019) · Nature reviews. Neuroscience · doi:10.1038/s41583-019-0121-9 · Cited by 175 · see citing works

HDAC inhibitors attenuate the development of hypersensitivity in models of neuropathic pain

Denk, F., Huang, W. L., Sidders, B. S., Bithell, A., Crow, M., Grist, J., Sharma, S., Ziemek, D., Rice, A. S. C., Buckley, N. J., et al. (2013) · Pain · doi:10.1016/j.pain.2013.05.021 · Cited by 172 · see citing works

Epigenetic Alterations in Alzheimer’s Disease

Sanchez-Mut, J. V., & Gräff, J. (2015) · Frontiers in Behavioral Neuroscience · doi:10.3389/fnbeh.2015.00347 · Cited by 168 · see citing works

LSD1n is an H4K20 demethylase regulating memory formation via transcriptional elongation control

Wang, J., Telese, F., Tan, Y., Li, W., Jin, C., He, X., Basnet, H., Ma, Q., Merkurjev, D., Zhu, X., et al. (2015) · Nature Neuroscience · doi:10.1038/nn.4069 · Cited by 169 · see citing works

Single-Cell Sequencing of iPSC-Dopamine Neurons Reconstructs Disease Progression and Identifies HDAC4 as a Regulator of Parkinson Cell Phenotypes

Lang, C., Campbell, K. R., Ryan, B. J., Carling, P. J., Attar, M., Vowles, J., Perestenko, O. V., Bowden, R. J., Baig, F., Kasten, M., et al. (2018) · Cell stem cell · doi:10.1016/j.stem.2018.10.023 · Cited by 170 · see citing works

LRP8-Reelin-regulated neuronal enhancer signature underlying learning and memory formation

Telese, F., Ma, Q., Perez, P. M., Notani, D., Oh, S., Li, W., Comoletti, D., Ohgi, K. A., Taylor, H., & Rosenfeld, M. G. (2015) · Neuron · doi:10.1016/j.neuron.2015.03.033 · Cited by 166 · see citing works

Proliferation and differentiation deficits are a major convergence point for neurodevelopmental disorders

Ernst, C. (2016) · Trends in Neurosciences · doi:10.1016/j.tins.2016.03.001 · Cited by 145 · see citing works

Histone deacetylases (HDACs) and brain function

Volmar, C.-H., & Wahlestedt, C. (2015) · Neuroepigenetics · doi:10.1016/j.nepig.2014.10.002 · Cited by 151 · see citing works

Long‐term plasticity in the hippocampus: maintaining within and ‘tagging’ between synapses

Bin Ibrahim, M. Z., Benoy, A., & Sajikumar, S. (2022) · The FEBS Journal · doi:10.1111/febs.16065 · Cited by 137 · see citing works

HDAC3 Is a Negative Regulator of Cocaine-Context-Associated Memory Formation

Rogge, G. A., Singh, H., Dang, R., & Wood, M. A. (2013) · Journal of Neuroscience · doi:10.1523/jneurosci.4472-12.2013 · Cited by 124 · see citing works

The promise and perils of HDAC inhibitors in neurodegeneration

Didonna, A., & Opal, P. (2014) · Annals of Clinical and Translational Neurology · doi:10.1002/acn3.147 · Cited by 120 · see citing works

Synaptic Dysfunction in Alzheimer’s Disease: Aβ, Tau, and Epigenetic Alterations

Li, K., Wei, Q., Liu, F., Hu, F., Xie, A., Zhu, L., & Liu, D. (2017) · Molecular Neurobiology · doi:10.1007/s12035-017-0533-3 · Cited by 119 · see citing works

HDAC4 as a potential therapeutic target in neurodegenerative diseases: a summary of recent achievements

Mielcarek, M., Zielonka, D., Carnemolla, A., Marcinkowski, T., & Guidez, F. (2015) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2015.00042 · Cited by 111 · see citing works

Epigenetic modifications in the nervous system and their impact upon cognitive impairments

Rudenko, A., & Tsai, L. (2014) · Neuropharmacology · doi:10.1016/j.neuropharm.2014.01.043 · Cited by 108 · see citing works

Epigenetic memory: The Lamarckian brain

Fischer, A. (2014) · The EMBO Journal · doi:10.1002/embj.201387637 · Cited by 107 · see citing works

HDAC4: a key factor underlying brain developmental alterations in CDKL5 disorder

Trazzi, S., Fuchs, C., Viggiano, R., Franceschi, M. D., Valli, E., Jedynak, P., Hansen, F. K., Perini, G., Rimondini, R., Kurz, T., et al. (2016) · Human Molecular Genetics · doi:10.1093/hmg/ddw231 · Cited by 101 · see citing works

Estrogen-dependent association of HDAC4 with fear in female mice and women with PTSD

Maddox, S. A., Kilaru, V., Shin, J. H., Jovanović, T., Almli, L. M., Dias, B. G., Norrholm, S. D., Fani, N., Michopoulos, V., Ding, Z., et al. (2017) · Molecular Psychiatry · doi:10.1038/mp.2016.250 · Cited by 104 · see citing works

Inducible control of gene expression with destabilized Cre

Sando, R. C., Baumgaertel, K., Pieraut, S., Torabi-Rander, N., Wandless, T. J., Mayford, M. R., & Maximov, A. (2013) · Nature Methods · doi:10.1038/nmeth.2640 · Cited by 102 · see citing works

Neuropathic MORC2 mutations perturb GHKL ATPase dimerization dynamics and epigenetic silencing by multiple structural mechanisms

Douse, C. H., Bloor, S., Liu, Y., Shamin, M., Tchasovnikarova, I. A., Timms, R. T., Lehner, P. J., & Modis, Y. (2018) · Nature Communications · doi:10.1038/s41467-018-03045-x · Cited by 101 · see citing works

Transcription, Epigenetics and Ameliorative Strategies in Huntington’s Disease: a Genome-Wide Perspective

Valor, L. M. (2014) · Molecular Neurobiology · doi:10.1007/s12035-014-8715-8 · Cited by 99 · see citing works

Histone Methylation by the Kleefstra Syndrome Protein EHMT1 Mediates Homeostatic Synaptic Scaling

Benevento, M., Iacono, G. L., Selten, M. M., Ba, W., Oudakker, A. R., Frega, M., Keller, J., Mancini, R., Lewerissa, E., Kleefstra, T., et al. (2016) · Neuron · doi:10.1016/j.neuron.2016.06.003 · Cited by 94 · see citing works

Towards Selective Inhibition of Histone Deacetylase Isoforms: What Has Been Achieved, Where We Are and What Will Be Next

Thaler, F., & Mercurio, C. (2013) · ChemMedChem · doi:10.1002/cmdc.201300413 · Cited by 95 · see citing works

Hippocampal proteomics defines pathways associated with memory decline and resilience in normal aging and Alzheimer’s disease mouse models

Neuner, S. M., Wilmott, L. A., Hoffmann, B. R., Mozhui, K., & Kaczorowski, C. C. (2016) · Behavioural Brain Research · doi:10.1016/j.bbr.2016.06.002 · Cited by 93 · see citing works

Kinase signalling in excitatory neurons regulates sleep quantity and depth

Kim, S. J., Hotta-Hirashima, N., Asano, F., Kitazono, T., Iwasaki, K., Nakata, S., Komiya, H., Asama, N., Matsuoka, T., Fujiyama, T., et al. (2022) · Nature · doi:10.1038/s41586-022-05450-1 · Cited by 96 · see citing works

Molecular and Synaptic Bases of CDKL5 Disorder

Zhu, Y., & Xiong, Z. (2018) · Developmental Neurobiology · doi:10.1002/dneu.22639 · Cited by 94 · see citing works

The Genetics of Autism Spectrum Disorders

Huguet, G., Benabou, M., & Bourgeron, T. (2016) · Research and perspectives in endocrine interactions · doi:10.1007/978-3-319-27069-2_11 · Cited by 94 · see citing works

Eating disorder predisposition is associated with ESRRA and HDAC4 mutations

Cui, H., Moore, J., Ashimi, S. S., Mason, B. L., Drawbridge, J. N., Han, S., Hing, B. W. Q., Matthews, A. L., McAdams, C. J., Darbro, B. W., et al. (2013) · Journal of Clinical Investigation · doi:10.1172/jci71400 · Cited by 85 · see citing works

Synaptotagmin-11 mediates a vesicle trafficking pathway that is essential for development and synaptic plasticityPreprint

Shimojo, M., Madara, J. C., Pankow, S., Liu, X., Yates, J., Südhof, T., & Maximov, A. (2019) · Genes & Development · doi:10.1101/gad.320077.118 · Cited by 59 · see citing works

Hippocampal HDAC4 Contributes to Postnatal Fluoxetine-Evoked Depression-Like Behavior

Sarkar, A., Chachra, P., Kennedy, P., Pena, C. J., Desouza, L. A., Nestler, E. J., & Vaidya, V. A. (2014) · Neuropsychopharmacology · doi:10.1038/npp.2014.73 · Cited by 79 · see citing works

The Histone Deacetylase HDAC4 Regulates Long-Term Memory in Drosophila

Fitzsimons, H. L., Schwartz, S., Given, F. M., & Scott, M. J. (2013) · PLoS ONE · doi:10.1371/journal.pone.0083903 · Cited by 77 · see citing works

Pharmacological intervention of histone deacetylase enzymes in the neurodegenerative disorders

Gupta, R. V., Ambasta, R. K., & Kumar, P. (2020) · Life Sciences · doi:10.1016/j.lfs.2020.117278 · Cited by 79 · see citing works

Epigenetics, a key for unlocking complex CNS disorders? Therapeutic implications

Szyf, M. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2014.01.009 · Cited by 76 · see citing works

Nuclear Calcium Signaling Regulates Nuclear Export of a Subset of Class IIa Histone Deacetylases following Synaptic Activity

Schlumm, F., Mauceri, D., Freitag, H. E., & Bading, H. (2013) · Journal of Biological Chemistry · doi:10.1074/jbc.m112.432773 · Cited by 76 · see citing works

A signalling pathway for transcriptional regulation of sleep amount in mice

Zhou, R., Wang, G., Li, Q., Meng, F., Liu, C., Gan, R., Ju, D., Liao, M., Xu, J., Sang, D., et al. (2022) · Nature · doi:10.1038/s41586-022-05510-6 · Cited by 76 · see citing works

Unique functional roles for class I and class II histone deacetylases in central nervous system development and function

Morris, M. J., & Monteggia, L. M. (2013) · International Journal of Developmental Neuroscience · doi:10.1016/j.ijdevneu.2013.02.005 · Cited by 75 · see citing works

Quantification of Histone Deacetylase Isoforms in Human Frontal Cortex, Human Retina, and Mouse Brain

Anderson, K. W., Chen, J., Wang, M., Mast, N., Pikuleva, I. A., & Turko, I. V. (2015) · PLoS ONE · doi:10.1371/journal.pone.0126592 · Cited by 69 · see citing works

Chronic stress and antidepressant induced changes in Hdac5 and Sirt2 affect synaptic plasticity

Erburu, M. M., Muñoz-Cobo, I., Domínguez‐Andrés, J., Beltrán, E., Suzuki, T., Mai, A., Valente, S., Puerta, E., & Tordera, R. M. (2015) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2015.08.016 · Cited by 71 · see citing works

Epigenetics in Neurodevelopment: Emerging Role of Circular RNA

Meng, S., Zhou, H., Feng, Z., Xu, Z., Tang, Y., & Wu, M. (2019) · Frontiers in Cellular Neuroscience · doi:10.3389/fncel.2019.00327 · Cited by 70 · see citing works

HDAC4 degradation during senescence unleashes an epigenetic program driven by AP-1/p300 at selected enhancers and super-enhancers

Giorgio, E. D., Paluvai, H., Dalla, E., Ranzino, L., Renzini, A., Moresi, V., Minisini, M., Picco, R., & Brancolini, C. (2021) · Genome biology · doi:10.1186/s13059-021-02340-z · Cited by 67 · see citing works

Aging Triggers a Repressive Chromatin State at Bdnf Promoters in Hippocampal Neurons

Palomer, E., Martín‐Segura, A., Baliyan, S., Ahmed, T., Balschun, D., Venero, C., Martín, M. G., & Dotti, C. G. (2016) · Cell Reports · doi:10.1016/j.celrep.2016.08.028 · Cited by 66 · see citing works

Hemispheric asymmetry in the human brain and in Parkinson’s disease is linked to divergent epigenetic patterns in neurons

Li, P., Ensink, E., Lang, S., Marshall, L. L., Schilthuis, M., Lamp, J. A., Vega, I. E., & Labrie, V. (2020) · Genome biology · doi:10.1186/s13059-020-01960-1 · Cited by 65 · see citing works

Nuclear Accumulation of Histone Deacetylase 4 (HDAC4) Exerts Neurotoxicity in Models of Parkinson’s Disease

Wu, Q., Yang, X., Zhang, L., Zhang, Y., & Feng, L. (2016) · Molecular Neurobiology · doi:10.1007/s12035-016-0199-2 · Cited by 66 · see citing works

Epigenetic regulation of estrogen-dependent memory

Fortress, A. M., & Frick, K. M. (2014) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2014.05.001 · Cited by 62 · see citing works

Context and Auditory Fear are Differentially Regulated by HDAC3 Activity in the Lateral and Basal Subnuclei of the Amygdala

Kwapis, J. L., Alaghband, Y., López, A. J., White, A. O., Campbell, R. R., Dang, R., Rhee, D., Tran, A. V., Carl, A. E., Matheos, D. P., et al. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.274 · Cited by 62 · see citing works

Role of Epigenetic Mechanisms in Chronic Pain

Mauceri, D. (2022) · Cells · doi:10.3390/cells11162613 · Cited by 61 · see citing works

Prior alcohol use enhances vulnerability to compulsive cocaine self-administration by promoting degradation of HDAC4 and HDAC5

Griffin, E. A., Melas, P. A., Zhou, R. W., Li, Y., Mercado, P., Kempadoo, K. A., Stephenson, S. I., Colnaghi, L., Taylor, K. M., Hu, M., et al. (2017) · Science Advances · doi:10.1126/sciadv.1701682 · Cited by 61 · see citing works

Developmental disorders with intellectual disability driven by chromatin dysregulation: Clinical overlaps and molecular mechanisms

Larizza, L., & Finelli, P. (2018) · Clinical Genetics · doi:10.1111/cge.13365 · Cited by 57 · see citing works

Manganese chloride induces histone acetylation changes in neuronal cells: Its role in manganese-induced damage

Guo, Z., Zhang, Z., Wang, Q., Zhang, J., Wang, L., Zhang, Q., Li, H., & Wu, S. (2017) · NeuroToxicology · doi:10.1016/j.neuro.2017.11.003 · Cited by 58 · see citing works

Epigenetic regulation in memory and cognitive disorders

Rudenko, A., & Tsai, L. (2013) · Neuroscience · doi:10.1016/j.neuroscience.2012.12.034 · Cited by 56 · see citing works

Mechanisms of epigenetic memory and addiction

Tuesta, L. M., & Zhang, Y. (2014) · The EMBO Journal · doi:10.1002/embj.201488106 · Cited by 57 · see citing works

Impaired Regulation of Histone Methylation and Acetylation Underlies Specific Neurodevelopmental Disorders

Fallah, M. S., Szarics, D., Robson, C. M., & Eubanks, J. H. (2021) · Frontiers in Genetics · doi:10.3389/fgene.2020.613098 · Cited by 57 · see citing works

Class IIa HDACs regulate learning and memory through dynamic experience-dependent repression of transcription

Zhu, Y., Huang, M., Bushong, E. A., Phan, S., Uytiepo, M., Beutter, E., Boemer, D., Tsui, K. C., Ellisman, M. H., & Maximov, A. (2019) · Nature Communications · doi:10.1038/s41467-019-11409-0 · Cited by 53 · see citing works

Neuroendocrine pathways underlying risk and resilience to PTSD in women

Ravi, M., Stevens, J. S., & Michopoulos, V. (2019) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2019.100790 · Cited by 55 · see citing works

A brain proteomic signature of incipient Alzheimer’s disease in young <i>APOE</i> ε4 carriers identifies novel drug targets

Roberts, J. A., Varma, V. R., An, Y., Varma, S., Candia, J., Fantoni, G., Tiwari, V., Anerillas, C., Williamson, A., Saito, A., et al. (2021) · Science Advances · doi:10.1126/sciadv.abi8178 · Cited by 49 · see citing works

Immunotherapies targeting stimulatory pathways and beyond

Marin-Acevedo, J. A., Kimbrough, E. O., Manochakian, R., Zhao, Y., & Lou, Y. (2021) · Journal of Hematology &amp; Oncology · doi:10.1186/s13045-021-01085-3 · Cited by 52 · see citing works

Aberrant Expression of Histone Deacetylases 4 in Cognitive Disorders: Molecular Mechanisms and a Potential Target

Wu, Y., Hou, F., Wang, X., Kong, Q., Han, X., & Bai, B. (2016) · Frontiers in Molecular Neuroscience · doi:10.3389/fnmol.2016.00114 · Cited by 52 · see citing works

ARNT2 Tunes Activity-Dependent Gene Expression through NCoR2-Mediated Repression and NPAS4-Mediated Activation

Sharma, N., Pollina, E. A., Nagy, M. A., Yap, E.-L., DiBiase, F. A., Hrvatin, S., Hu, L. S., Lin, C., & Greenberg, M. E. (2019) · Neuron · doi:10.1016/j.neuron.2019.02.007 · Cited by 50 · see citing works

Cul3 and insomniac are required for rapid ubiquitination of postsynaptic targets and retrograde homeostatic signaling

Kikuma, K., Li, X., Perry, S., Li, Q., Goel, P., Chen, C., Kim, D., Stavropoulos, N., & Dickman, D. K. (2019) · Nature Communications · doi:10.1038/s41467-019-10992-6 · Cited by 53 · see citing works

ADRAM is an experience-dependent long noncoding RNA that drives fear extinction through a direct interaction with the chaperone protein 14-3-3

Wei, W., Zhao, Q., Wang, Z., Liau, W., Basic, D., Ren, H., Marshall, P. R., Zajaczkowski, E. L., Leighton, L. J., Madugalle, S. U., et al. (2022) · Cell Reports · doi:10.1016/j.celrep.2022.110546 · Cited by 47 · see citing works

Epigenetic Targeting of Histone Deacetylases in Diagnostics and Treatment of Depression

Park, H., Kim, J., Ahn, S. H., & Ryu, H. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22105398 · Cited by 50 · see citing works

An Evolutionary Genetic Perspective of Eating Disorders

Mayhew, A., Pigeyre, M., Couturier, J. L., & Meyre, D. (2017) · Neuroendocrinology · doi:10.1159/000484525 · Cited by 48 · see citing works

HDAC4 in ischemic stroke: mechanisms and therapeutic potential

Kong, Q., Hao, Y., Li, X., Wang, X., Ji, B., & Wu, Y. (2018) · Clinical Epigenetics · doi:10.1186/s13148-018-0549-1 · Cited by 47 · see citing works

Genotype and phenotype correlation in 103 individuals with 2q37 deletion syndrome reveals incomplete penetrance and supports HDAC4 as the primary genetic contributor

Le, T. N. H., Williams, S. R., Alaimo, J. T., & Elsea, S. H. (2019) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.61089 · Cited by 45 · see citing works

ATM-deficiency-induced microglial activation promotes neurodegeneration in ataxia-telangiectasia

Lai, J. F., Demirbas, D., Kim, J., Jeffries, A. M., Tolles, A. K., Park, J., Chittenden, T. W., Buckley, P. G., Yu, T. W., Lodato, M. A., et al. (2023) · Cell Reports · doi:10.1016/j.celrep.2023.113622 · Cited by 42 · see citing works

Modulation of Nerve Injury–induced HDAC4 Cytoplasmic Retention Contributes to Neuropathic Pain in Rats

Lin, T.-B., Hsieh, M., Lai, C., Cheng, J., Chau, Y., Ruan, T., Chen, G., & Peng, H. (2015) · Anesthesiology · doi:10.1097/aln.0000000000000663 · Cited by 44 · see citing works

Peripheral Neuropathic Pain: From Experimental Models to Potential Therapeutic Targets in Dorsal Root Ganglion Neurons

Yeh, T., Luo, I.-W., Hsieh, Y., Tseng, T.-J., Chiang, H., & Hsieh, S. (2020) · Cells · doi:10.3390/cells9122725 · Cited by 43 · see citing works

The Epigenetics of Migraine

Zobdeh, F., Еременко, И. И., Akan, M. A., Tarasov, V. V., Chubarev, V. N., Schiöth, H. B., & Mwinyi, J. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24119127 · Cited by 42 · see citing works

Histone-acetylation: a link between Alzheimer's disease and post-traumatic stress disorder?

Bahari‐Javan, S., Sananbenesi, F., & Fischer, A. (2014) · Frontiers in Neuroscience · doi:10.3389/fnins.2014.00160 · Cited by 41 · see citing works

Histone deacetylases 1 and 2 are required for brain development

Jaworska, J., Ziemka‐Nałęcz, M., & Zalewska, T. (2015) · The International Journal of Developmental Biology · doi:10.1387/ijdb.150071tz · Cited by 41 · see citing works

The Class IIa histone deacetylase HDAC4 and neuronal function: Nuclear nuisance and cytoplasmic stalwart?

Fitzsimons, H. L. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.06.006 · Cited by 41 · see citing works

The role of nuclear Ca2+ in maintaining neuronal homeostasis and brain health

Mozolewski, P., Jeziorek, M., Schuster, C., Bading, H., Frost, B. E., & Dobrowolski, R. (2021) · Journal of Cell Science · doi:10.1242/jcs.254904 · Cited by 39 · see citing works

Interleukin 1β triggers synaptic and memory deficits in Herpes simplex virus type-1-infected mice by downregulating the expression of synaptic plasticity-related genes via the epigenetic MeCP2/HDAC4 complex

Puma, D. D. L., Colussi, C., Bandiera, B., Puliatti, G., Rinaudo, M., Cocco, S., Paciello, F., Re, A., Ripoli, C., Chiara, G. D., et al. (2023) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-023-04817-5 · Cited by 39 · see citing works

Swimming exercise ameliorates neurocognitive impairment induced by neonatal exposure to isoflurane and enhances hippocampal histone acetylation in mice

Zhong, T., Ren, F., Huang, C., Zou, W., Yu, Y., Pan, Y., Sun, B., Wang, E., & Guo, Q. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.12.049 · Cited by 38 · see citing works

Regulation of Neuronal Gene Expression and Survival by Basal NMDA Receptor Activity: A Role for Histone Deacetylase 4

Chen, Y., Wang, Y., Modrusan, Z. D., Sheng, M., & Kaminker, J. S. (2014) · Journal of Neuroscience · doi:10.1523/jneurosci.0569-14.2014 · Cited by 38 · see citing works

HDAC4 is required for inflammation-associated thermal hypersensitivity

Crow, M., Khovanov, N., Kelleher, J. H., Sharma, S., Grant, A. D., Bogdanov, Y. D., Wood, J. N., McMahon, S. B., & Denk, F. (2015) · The FASEB Journal · doi:10.1096/fj.14-264440 · Cited by 37 · see citing works

Long-Term Memory inDrosophilaIs Influenced by Histone Deacetylase HDAC4 Interacting with SUMO-Conjugating Enzyme Ubc9

Schwartz, S., Truglio, M., Scott, M. J., & Fitzsimons, H. L. (2016) · Genetics · doi:10.1534/genetics.115.183194 · Cited by 36 · see citing works

Paeoniflorin ameliorates ischemic injury in rat brain via inhibiting cytochrome c/caspase3/HDAC4 pathway

Liu, Y., Zhang, L., Wu, Q., & Feng, L. (2021) · Acta Pharmacologica Sinica · doi:10.1038/s41401-021-00671-y · Cited by 37 · see citing works

Environmental stimulation rescues maternal high fructose intake-impaired learning and memory in female offspring: Its correlation with redistribution of histone deacetylase 4

Wu, K. L. H., Wu, C., Tain, Y., Huang, L., Chao, Y., Hung, C., Wu, J., Chen, S.-R., Tsai, P.-C., & Chan, J. Y. H. (2016) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2016.02.004 · Cited by 36 · see citing works

MiR-206-3p alleviates chronic constriction injury-induced neuropathic pain through targeting HDAC4

Wen, J., He, T., Qi, F., & Chen, H. (2018) · EXPERIMENTAL ANIMALS · doi:10.1538/expanim.18-0091 · Cited by 36 · see citing works

Early stress evokes dysregulation of histone modifiers in the medial prefrontal cortex across the life span

Pusalkar, M., Suri, D., Kelkar, A., Bhattacharya, A., Galande, S., & Vaidya, V. A. (2015) · Developmental Psychobiology · doi:10.1002/dev.21365 · Cited by 35 · see citing works

Haploinsufficiency of HDAC4 does not cause intellectual disability in all affected individuals

Wheeler, P. G., Huang, D., & Zunyan Dai, Y. (2014) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.36542 · Cited by 35 · see citing works

Activity-Dependent Gene Expression in Neurons

Lee, P. R., & Fields, R. D. (2020) · The Neuroscientist · doi:10.1177/1073858420943515 · Cited by 35 · see citing works

Evaluation of Class IIa Histone Deacetylases Expression and In Vivo Epigenetic Imaging in a Transgenic Mouse Model of Alzheimer’s Disease

Chen, Y., Lu, C.-H., Ke, C., Chiu, S.-J., Chang, C., Yang, B., Gelovani, J. G., & Liu, R.-S. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22168633 · Cited by 32 · see citing works

Developing HDAC4-Selective Protein Degraders To Investigate the Role of HDAC4 in Huntington’s Disease Pathology

Macabuag, N., Esmieu, W., Breccia, P., Jarvis, R. E., Blackaby, W., Lazari, O., Urbonas, L., Eznarriaga, M., Williams, R., Strijbosch, A., et al. (2022) · Journal of Medicinal Chemistry · doi:10.1021/acs.jmedchem.2c01149 · Cited by 34 · see citing works

The Class IIa histone deacetylase HDAC4 and neuronal function: Nuclear nuisance and cytoplasmic stalwart?

Fitzsimons, H. L. (2015) · Neurobiology of Learning and Memory · doi:10.1016/j.nlm.2015.06.006 · Cited by 41 · see citing works

Analysis of the first spectrum of vanadium

(1936) · Journal of the Franklin Institute · doi:10.1016/s0016-0032(36)90737-8

An Essential Role for Histone Deacetylase 4 in Synaptic Plasticity and Memory Formation

Kim, M.-S., Akhtar, M. W., Adachi, M., Mahgoub, M., Bassel-Duby, R., Kavalali, E. T., Olson, E. N., & Monteggia, L. M. (2012) · The Journal of Neuroscience · doi:10.1523/jneurosci.2089-12.2012 · Cited by 235 · see citing works

Characterization of HDAC4's Role in Brain

(2010) · DigiNole (Florida State University)

HDAC2 negatively regulates memory formation and synaptic plasticity

Guan, J.-S., Haggarty, S. J., Giacometti, E., Dannenberg, J.-H., Joseph, N., Gao, J., Nieland, T. J. F., Zhou, Y., Wang, X., Mazitschek, R., et al. (2009) · Nature · doi:10.1038/nature07925 · Cited by 1,644 · see citing works