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Cited by 522

The DOI matches its Crossref record; 57 of the 57 references it cites were found in a registry or an index.

Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice

Open access
Yildirim, Eda, Kirby, James E., Brown, Diane E., Mercier, Francois E., Sadreyev, Ruslan I., Scadden, David T., Lee, Jeannie T.·2013·Cell
DOI 10.1016/j.cell.2013.01.034
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Abstract

SUMMARY X chromosome aneuploidies have long been associated with human cancers, but causality has not been established. In mammals, X chromosome inactivation (XCI) is triggered by Xist RNA to equalize gene expression between the sexes. Here we delete Xist in the blood compartment of mice and demonstrate that mutant females develop a highly aggressive myeloproliferative neoplasm and myelodysplastic syndrome (mixed MPN/MDS) with 100% penetrance. Significant disease components include primary myelofibrosis, leukemia, histiocytic sarcoma, and vasculitis. Xist-deficient hematopoietic stem cells (HSCs) show aberrant maturation and age-dependent loss. Reconstitution experiments indicate that MPN/MDS and myelofibrosis are of hematopoietic rather than stromal origin. We propose that Xist loss results in X reactivation and consequent genome-wide changes that lead to cancer, thereby causally linking the X chromosome to cancer in mice. Thus, Xist RNA not only is required to maintain XCI but also suppresses cancer in vivo.

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Metadata

Authors
Yildirim, E., Kirby, J. E., Brown, D. E., Mercier, F. E., Sadreyev, R. I., Scadden, D. T., & Lee, J. T.
Venue
Cell
Publisher
Elsevier BV
Published
2013-02
Volume
152
Issue
4
Pages
727-742
ISSN
0092-8674 (ISSN-L)
DOI
10.1016/j.cell.2013.01.034
OpenAlex
W2171577249
Cited by
522
References
57
FWCI
35.81
Type
journal article
Language
en
Open access
bronze

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CoChat. (2026). Citation check: Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice. https://app.cochat.ai/papers/10.1016/j.cell.2013.01.034
The paper
Yildirim, E., Kirby, J. E., Brown, D. E., Mercier, F. E., Sadreyev, R. I., Scadden, D. T., & Lee, J. T. (2013). Xist RNA Is a Potent Suppressor of Hematologic Cancer in Mice. Cell. https://doi.org/10.1016/j.cell.2013.01.034

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.