The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells
Open accessAbstract
SUMMARY Epigenetic mechanisms have been proposed to play crucial roles in mammalian development, but their precise functions are only partially understood. To investigate epigenetic regulation of embryonic development, we differentiated human embryonic stem cells into mesendoderm, neural progenitor cells, trophoblast-like cells, and mesenchymal stem cells, and systematically characterized DNA methylation, chromatin modifications, and the transcriptome in each lineage. We found that promoters that are active in early developmental stages tend to be CG rich and mainly engage H3K27me3 upon silencing in non-expressing lineages. By contrast, promoters for genes expressed preferentially at later stages are often CG poor and primarily employ DNA methylation upon repression. Interestingly, the early developmental regulatory genes are often located in large genomic domains that are generally devoid of DNA methylation in most lineages, which we termed DNA methylation valleys (DMVs). Our results suggest that distinct epigenetic mechanisms regulate early and late stages of ES cell differentiation.
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Cites
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Self-citationGREAT improves functional interpretation of cis-regulatory regions
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Cited by
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Metadata
- Authors
- Xie, W., Schultz, M. D., Lister, R., Hou, Z., Rajagopal, N., Ray, P., Whitaker, J. W., Tian, S., Hawkins, R. D., Leung, D., Yang, H., Wang, T., Lee, A. Y., Swanson, S. A., Zhang, J., Zhu, Y., Kim, A., Nery, J. R., Urich, M. A., Kuan, S., Yen, C.-A., Klugman, S., Yu, P., Suknuntha, K., Propson, N. E., Chen, H., Edsall, L. E., Wagner, U., Li, Y., Ye, Z., Kulkarni, A., Xuan, Z., Chung, W.-Y., Chi, N. C., Antosiewicz-Bourget, J. E., Slukvin, I., Stewart, R., Zhang, M. Q., Wang, W., Thomson, J. A., Ecker, J. R., & Ren, B.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-05
- Volume
- 153
- Issue
- 5
- Pages
- 1134-1148
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2157232603
- Cited by
- 735
- References
- 21
- FWCI
- 36.58
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Xie, W., Schultz, M. D., Lister, R., Hou, Z., Rajagopal, N., Ray, P., Whitaker, J. W., Tian, S., Hawkins, R. D., Leung, D., Yang, H., Wang, T., Lee, A. Y., Swanson, S. A., Zhang, J., Zhu, Y., Kim, A., Nery, J. R., Urich, M. A., . . . Ren, B. (2013). Epigenomic Analysis of Multilineage Differentiation of Human Embryonic Stem Cells. Cell. https://doi.org/10.1016/j.cell.2013.04.022
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