The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules
Open accessAbstract
Summary The high rate of clinical response to protein kinase-targeting drugs matched to cancer patients with specific genomic alterations has prompted efforts to use cancer cell-line (CCL) profiling to identify additional biomarkers of small-molecule sensitivities. We have quantitatively measured the sensitivity of 242 genomically characterized CCLs to an Informer Set of 354 small molecules that target many nodes in cell circuitry, uncovering protein dependencies that: 1) associate with specific cancer-genomic alterations and 2) can be targeted by small molecules. We have created the Cancer Therapeutics Response Portal (www.broadinstitute.org/ctrp) to enable users to correlate genetic features to sensitivity in individual lineages and control for confounding factors of CCL profiling. We report a candidate dependency, associating activating mutations in the oncogene β-catenin with sensitivity to the Bcl2-family antagonist, navitoclax. The resource can be used to develop novel therapeutic hypotheses and accelerate discovery of drugs matched to patients by their cancer genotype and lineage.
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Metadata
- Authors
- Basu, A., Bodycombe, N. E., Cheah, J. H., Price, E. V., Liu, K., Schaefer, G. I., Ebright, R. Y., Stewart, M. L., Ito, D., Wang, S., Bracha, A. L., Liefeld, T., Wawer, M., Gilbert, J. C., Wilson, A. J., Stransky, N., Kryukov, G. V., Dancik, V., Barretina, J., Garraway, L. A., Hon, C. S.-Y., Munoz, B., Bittker, J. A., Stockwell, B. R., Khabele, D., Stern, A. M., Clemons, P. A., Shamji, A. F., & Schreiber, S. L.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2013-08
- Volume
- 154
- Issue
- 5
- Pages
- 1151-1161
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2152883907
- Cited by
- 833
- References
- 51
- FWCI
- 10.66
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Basu, A., Bodycombe, N. E., Cheah, J. H., Price, E. V., Liu, K., Schaefer, G. I., Ebright, R. Y., Stewart, M. L., Ito, D., Wang, S., Bracha, A. L., Liefeld, T., Wawer, M., Gilbert, J. C., Wilson, A. J., Stransky, N., Kryukov, G. V., Dancik, V., Barretina, J., . . . Schreiber, S. L. (2013). An Interactive Resource to Identify Cancer Genetic and Lineage Dependencies Targeted by Small Molecules. Cell. https://doi.org/10.1016/j.cell.2013.08.003
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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