The DOI matches its Crossref record; 149 of the 149 references it cites were found in a registry or an index.
Structural Insights on the Role of Antibodies in HIV-1 Vaccine and Therapy
Open accessAbstract
Despite 30 years of effort, there is no effective vaccine for HIV-1. However, antibodies can prevent HIV-1 infection in humanized mice and macaques when passively transferred. New single-cell-based methods have uncovered many broad and potent donor-derived antibodies, and structural studies have revealed the molecular bases for their activities. The new data suggest why such antibodies are difficult to elicit and inform HIV-1 vaccine development efforts. In addition to protecting against infection, the newly identified antibodies can suppress active infections in mice and macaques, suggesting they could be valuable additions to anti-HIV-1 therapies and to strategies to eradicate HIV-1 infection.
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Cited by
Vinuesa, C. G., Linterman, M. A., Yu, D., & MacLennan, I. C. M. (2016) · Annual Review of Immunology · doi:10.1146/annurev-immunol-041015-055605 · Cited by 1,141
Viraemia suppressed in HIV-1-infected humans by broadly neutralizing antibody 3BNC117
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Self-citationClonal selection in the germinal centre by regulated proliferation and hypermutation
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Metadata
- Authors
- West, A. P., Scharf, L., Scheid, J. F., Klein, F., Bjorkman, P. J., & Nussenzweig, M. C.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-02
- Volume
- 156
- Issue
- 4
- Pages
- 633-648
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2037320559
- Cited by
- 321
- References
- 149
- FWCI
- 25.55
- Type
- journal article
- Language
- en
- Open access
- bronze
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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