The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
RETRACTED: A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief
Open accessAbstract
Summary Voltage-gated sodium (NaV) channels control the upstroke of the action potentials in excitable cells. Multiple studies have shown distinct roles of NaV channel subtypes in human physiology and diseases, but subtype-specific therapeutics are lacking and the current efforts have been limited to small molecules. Here we present a monoclonal antibody that targets the voltage-sensor paddle of NaV1.7, the subtype critical for pain sensation. This antibody not only inhibits NaV1.7 with high selectivity but also effectively suppresses inflammatory and neuropathic pain in mice. Interestingly, the antibody inhibits acute and chronic itch, despite well-documented differences in pain and itch modulation. Using this antibody, we discovered that NaV1.7 plays a key role in spinal cord nociceptive and pruriceptive synaptic transmission. Our studies reveal that NaV1.7 is a target for itch management and the antibody has therapeutic potential for suppressing pain and itch. Our antibody strategy may have broad applications for voltage-gated cation channels.
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Cites
Neuronal circuitry for pain processing in the dorsal horn
Todd, A. J. (2010) · Nature Reviews Neuroscience · doi:10.1038/nrn2947 · Cited by 1,475
McCormack, K., Santos, S., Chapman, M. L., Krafte, D. S., Marron, B. E., West, C. W., Krambis, M. J., Antonio, B. M., Zellmer, S. G., Printzenhoff, D., et al. (2013) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1220844110 · Cited by 244
Park, C.-K., Lü, N., Xu, Z.-Z., Liu, T., Serhan, C. N., & Ji, R.-R. (2011) · The Journal of Neuroscience · doi:10.1523/jneurosci.2443-11.2011 · Cited by 241
Self-citation
Cited by
New Horizons in Diabetic Neuropathy: Mechanisms, Bioenergetics, and Pain
Feldman, E. L., Nave, K.-A., Jensen, T. S., & Bennett, D. L. H. (2017) · Neuron · doi:10.1016/j.neuron.2017.02.005 · Cited by 915
The Role of Voltage-Gated Sodium Channels in Pain Signaling
Bennett, D. L., Clark, A. J., Huang, J., Waxman, S. G., & Dib-Hajj, S. D. (2019) · Physiological Reviews · doi:10.1152/physrev.00052.2017 · Cited by 730
Voltage-gated sodium channels: structure, function, pharmacology, and clinical indications
de Lera Ruiz, M., & Kraus, R. L. (2015) · Journal of Medicinal Chemistry · doi:10.1021/jm501981g · Cited by 548
Neural circuits for pain: Recent advances and current views
Peirs, C., & Seal, R. P. (2016) · Science · doi:10.1126/science.aaf8933 · Cited by 478
Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation
Changeux, J.-P., & Christopoulos, A. (2016) · Cell · doi:10.1016/j.cell.2016.08.015 · Cited by 336
Metadata
- Authors
- Lee, J.-H., Park, C.-K., Chen, G., Han, Q., Xie, R.-G., Liu, T., Ji, R.-R., & Lee, S.-Y.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2014-06
- Volume
- 157
- Issue
- 6
- Pages
- 1393-1404
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2046486142
- Cited by
- 207
- References
- 3
- FWCI
- 12.90
- Type
- journal article
- Language
- en
- Status
- Retracted
- Open access
- bronze
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- CoChat. (2026). Citation check: RETRACTED: A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief. https://app.cochat.ai/papers/10.1016/j.cell.2014.03.064
- The paper
- Lee, J.-H., Park, C.-K., Chen, G., Han, Q., Xie, R.-G., Liu, T., Ji, R.-R., & Lee, S.-Y. (2014). RETRACTED: A Monoclonal Antibody that Targets a NaV1.7 Channel Voltage Sensor for Pain and Itch Relief. Cell. https://doi.org/10.1016/j.cell.2014.03.064
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